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Q3ZZJ0

- NADK_DEHMC

UniProt

Q3ZZJ0 - NADK_DEHMC

Protein

NAD kinase

Gene

nadK

Organism
Dehalococcoides mccartyi (strain CBDB1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (27 Sep 2005)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei61 – 611Proton acceptorUniRule annotation
    Binding sitei66 – 661NADUniRule annotation
    Binding sitei147 – 1471NADUniRule annotation
    Binding sitei164 – 1641NADUniRule annotation
    Binding sitei166 – 1661NADUniRule annotation
    Binding sitei201 – 2011NAD; via carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi61 – 622NADUniRule annotation
    Nucleotide bindingi136 – 1372NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciDSP255470:GJXW-352-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:cbdbA419
    OrganismiDehalococcoides mccartyi (strain CBDB1)
    Taxonomic identifieri255470 [NCBI]
    Taxonomic lineageiBacteriaChloroflexiDehalococcoidiaDehalococcoidalesDehalococcoidaceaeDehalococcoides
    ProteomesiUP000000433: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 284284NAD kinasePRO_0000229631Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi255470.cbdb_A419.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3ZZJ0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    KOiK00858.
    OMAiDGHINID.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q3ZZJ0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYKKIGIIYH PLNPAACDLA IKLTAKLDSL GIENWSDSAW QADKLTSKMQ    50
    NTQLIFTTGG DGTILRTAHA ILPLEIPILS VNLGKVGFMT ELSPEDAISG 100
    LEKVLAGDGW IDERSLLEAE YLPHDSAQSR QFFVMNDAVV ARGQVARVIC 150
    VSVDINSQPF TTYKADGAIV STATGSTGYS YAAGGPVLQP NSADIILTPI 200
    LPHLGRGYSL VLPSDSTVDL QVNTWHEATL SIDGFINMQV SSGDTLRLRR 250
    SSKKVKFMRL RPNNYFYKEL DTKLKGNNES VYDR 284
    Length:284
    Mass (Da):31,097
    Last modified:September 27, 2005 - v1
    Checksum:i3FDD322336CC15E4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ965256 Genomic DNA. Translation: CAI82623.1.
    RefSeqiWP_011308980.1. NC_007356.1.
    YP_307539.1. NC_007356.1.

    Genome annotation databases

    EnsemblBacteriaiCAI82623; CAI82623; cbdbA419.
    GeneIDi3622681.
    KEGGideh:cbdb_A419.
    PATRICi21611003. VBIDehSp125902_0347.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ965256 Genomic DNA. Translation: CAI82623.1 .
    RefSeqi WP_011308980.1. NC_007356.1.
    YP_307539.1. NC_007356.1.

    3D structure databases

    ProteinModelPortali Q3ZZJ0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 255470.cbdb_A419.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAI82623 ; CAI82623 ; cbdbA419 .
    GeneIDi 3622681.
    KEGGi deh:cbdb_A419.
    PATRICi 21611003. VBIDehSp125902_0347.

    Phylogenomic databases

    eggNOGi COG0061.
    KOi K00858.
    OMAi DGHINID.
    OrthoDBi EOG6PZXDR.

    Enzyme and pathway databases

    BioCyci DSP255470:GJXW-352-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the chlorinated compound-respiring bacterium Dehalococcoides species strain CBDB1."
      Kube M., Beck A., Zinder S.H., Kuhl H., Reinhardt R., Adrian L.
      Nat. Biotechnol. 23:1269-1273(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CBDB1.

    Entry informationi

    Entry nameiNADK_DEHMC
    AccessioniPrimary (citable) accession number: Q3ZZJ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: September 27, 2005
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3