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Q3ZZJ0

- NADK_DEHMC

UniProt

Q3ZZJ0 - NADK_DEHMC

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Protein
NAD kinase
Gene
nadK, cbdbA419
Organism
Dehalococcoides mccartyi (strain CBDB1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei61 – 611Proton acceptor By similarity
Binding sitei66 – 661NAD By similarity
Binding sitei147 – 1471NAD By similarity
Binding sitei164 – 1641NAD By similarity
Binding sitei166 – 1661NAD By similarity
Binding sitei201 – 2011NAD; via carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi61 – 622NAD By similarity
Nucleotide bindingi136 – 1372NAD By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. NAD+ kinase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciDSP255470:GJXW-352-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase (EC:2.7.1.23)
Alternative name(s):
ATP-dependent NAD kinase
Gene namesi
Name:nadK
Ordered Locus Names:cbdbA419
OrganismiDehalococcoides mccartyi (strain CBDB1)
Taxonomic identifieri255470 [NCBI]
Taxonomic lineageiBacteriaChloroflexiDehalococcoidiaDehalococcoidalesDehalococcoidaceaeDehalococcoides
ProteomesiUP000000433: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 284284NAD kinaseUniRule annotation
PRO_0000229631Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi255470.cbdb_A419.

Structurei

3D structure databases

ProteinModelPortaliQ3ZZJ0.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.

Phylogenomic databases

eggNOGiCOG0061.
KOiK00858.
OMAiDGHINID.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3ZZJ0-1 [UniParc]FASTAAdd to Basket

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MYKKIGIIYH PLNPAACDLA IKLTAKLDSL GIENWSDSAW QADKLTSKMQ    50
NTQLIFTTGG DGTILRTAHA ILPLEIPILS VNLGKVGFMT ELSPEDAISG 100
LEKVLAGDGW IDERSLLEAE YLPHDSAQSR QFFVMNDAVV ARGQVARVIC 150
VSVDINSQPF TTYKADGAIV STATGSTGYS YAAGGPVLQP NSADIILTPI 200
LPHLGRGYSL VLPSDSTVDL QVNTWHEATL SIDGFINMQV SSGDTLRLRR 250
SSKKVKFMRL RPNNYFYKEL DTKLKGNNES VYDR 284
Length:284
Mass (Da):31,097
Last modified:September 27, 2005 - v1
Checksum:i3FDD322336CC15E4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ965256 Genomic DNA. Translation: CAI82623.1.
RefSeqiWP_011308980.1. NC_007356.1.
YP_307539.1. NC_007356.1.

Genome annotation databases

EnsemblBacteriaiCAI82623; CAI82623; cbdbA419.
GeneIDi3622681.
KEGGideh:cbdb_A419.
PATRICi21611003. VBIDehSp125902_0347.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ965256 Genomic DNA. Translation: CAI82623.1 .
RefSeqi WP_011308980.1. NC_007356.1.
YP_307539.1. NC_007356.1.

3D structure databases

ProteinModelPortali Q3ZZJ0.
ModBasei Search...

Protein-protein interaction databases

STRINGi 255470.cbdb_A419.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAI82623 ; CAI82623 ; cbdbA419 .
GeneIDi 3622681.
KEGGi deh:cbdb_A419.
PATRICi 21611003. VBIDehSp125902_0347.

Phylogenomic databases

eggNOGi COG0061.
KOi K00858.
OMAi DGHINID.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci DSP255470:GJXW-352-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the chlorinated compound-respiring bacterium Dehalococcoides species strain CBDB1."
    Kube M., Beck A., Zinder S.H., Kuhl H., Reinhardt R., Adrian L.
    Nat. Biotechnol. 23:1269-1273(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CBDB1.

Entry informationi

Entry nameiNADK_DEHMC
AccessioniPrimary (citable) accession number: Q3ZZJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: September 27, 2005
Last modified: September 3, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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