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Protein

NAD kinase

Gene

nadK

Organism
Dehalococcoides mccartyi (strain CBDB1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei61 – 611Proton acceptorUniRule annotation
Binding sitei66 – 661NADUniRule annotation
Binding sitei147 – 1471NADUniRule annotation
Binding sitei164 – 1641NADUniRule annotation
Binding sitei166 – 1661NADUniRule annotation
Binding sitei201 – 2011NAD; via carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi61 – 622NADUniRule annotation
Nucleotide bindingi136 – 1372NADUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciDSP255470:GJXW-352-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:cbdbA419
OrganismiDehalococcoides mccartyi (strain CBDB1)
Taxonomic identifieri255470 [NCBI]
Taxonomic lineageiBacteriaChloroflexiDehalococcoidiaDehalococcoidalesDehalococcoidaceaeDehalococcoides
ProteomesiUP000000433 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 284284NAD kinasePRO_0000229631Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi255470.cbdb_A419.

Structurei

3D structure databases

ProteinModelPortaliQ3ZZJ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0061.
KOiK00858.
OMAiLEIHKKS.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR016064. NAD/diacylglycerol_kinase.
IPR002504. NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3ZZJ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYKKIGIIYH PLNPAACDLA IKLTAKLDSL GIENWSDSAW QADKLTSKMQ
60 70 80 90 100
NTQLIFTTGG DGTILRTAHA ILPLEIPILS VNLGKVGFMT ELSPEDAISG
110 120 130 140 150
LEKVLAGDGW IDERSLLEAE YLPHDSAQSR QFFVMNDAVV ARGQVARVIC
160 170 180 190 200
VSVDINSQPF TTYKADGAIV STATGSTGYS YAAGGPVLQP NSADIILTPI
210 220 230 240 250
LPHLGRGYSL VLPSDSTVDL QVNTWHEATL SIDGFINMQV SSGDTLRLRR
260 270 280
SSKKVKFMRL RPNNYFYKEL DTKLKGNNES VYDR
Length:284
Mass (Da):31,097
Last modified:September 27, 2005 - v1
Checksum:i3FDD322336CC15E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ965256 Genomic DNA. Translation: CAI82623.1.
RefSeqiWP_011308980.1. NC_007356.1.
YP_307539.1. NC_007356.1.

Genome annotation databases

EnsemblBacteriaiCAI82623; CAI82623; cbdbA419.
KEGGideh:cbdb_A419.
PATRICi21611003. VBIDehSp125902_0347.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ965256 Genomic DNA. Translation: CAI82623.1.
RefSeqiWP_011308980.1. NC_007356.1.
YP_307539.1. NC_007356.1.

3D structure databases

ProteinModelPortaliQ3ZZJ0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi255470.cbdb_A419.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAI82623; CAI82623; cbdbA419.
KEGGideh:cbdb_A419.
PATRICi21611003. VBIDehSp125902_0347.

Phylogenomic databases

eggNOGiCOG0061.
KOiK00858.
OMAiLEIHKKS.
OrthoDBiEOG6PZXDR.

Enzyme and pathway databases

BioCyciDSP255470:GJXW-352-MONOMER.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR016064. NAD/diacylglycerol_kinase.
IPR002504. NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the chlorinated compound-respiring bacterium Dehalococcoides species strain CBDB1."
    Kube M., Beck A., Zinder S.H., Kuhl H., Reinhardt R., Adrian L.
    Nat. Biotechnol. 23:1269-1273(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CBDB1.

Entry informationi

Entry nameiNADK_DEHMC
AccessioniPrimary (citable) accession number: Q3ZZJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: September 27, 2005
Last modified: May 27, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.