Q3ZZJ0 (PPNK_DEHSC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable inorganic polyphosphate/ATP-NAD kinase
Short name=Poly(P)/ATP NAD kinase
EC=2.7.1.23

Gene names

Name:	ppnK
Ordered Locus Names:	cbdbA419

Organism

Dehalococcoides sp. (strain CBDB1) [Complete proteome] [HAMAP]

Taxonomic identifier

255470 [NCBI]

Taxonomic lineage

Bacteria › Chloroflexi › Dehalococcoidetes › Dehalococcoides

Protein attributes

Sequence length	284 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus By similarity. HAMAP MF_00361
Catalytic activity	ATP + NAD+ = ADP + NADP+. HAMAP MF_00361
Cofactor	Divalent metal ions By similarity. HAMAP MF_00361
Subcellular location	Cytoplasm By similarity HAMAP MF_00361.
Sequence similarities	Belongs to the NAD kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding NAD NADP Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW NAD+ kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 284	284	Probable inorganic polyphosphate/ATP-NAD kinase HAMAP MF_00361		PRO_0000229631

Sequences

	Sequence		Length	Mass (Da)
	Q3ZZJ0 [UniParc]. Last modified September 27, 2005. Version 1. Checksum: 3FDD322336CC15E4	FASTA	284	31,097
	10 20 30 40 50 60 MYKKIGIIYH PLNPAACDLA IKLTAKLDSL GIENWSDSAW QADKLTSKMQ NTQLIFTTGG 70 80 90 100 110 120 DGTILRTAHA ILPLEIPILS VNLGKVGFMT ELSPEDAISG LEKVLAGDGW IDERSLLEAE 130 140 150 160 170 180 YLPHDSAQSR QFFVMNDAVV ARGQVARVIC VSVDINSQPF TTYKADGAIV STATGSTGYS 190 200 210 220 230 240 YAAGGPVLQP NSADIILTPI LPHLGRGYSL VLPSDSTVDL QVNTWHEATL SIDGFINMQV 250 260 270 280 SSGDTLRLRR SSKKVKFMRL RPNNYFYKEL DTKLKGNNES VYDR

References

[1]

"Genome sequence of the chlorinated compound-respiring bacterium Dehalococcoides species strain CBDB1." Kube M., Beck A., Zinder S.H., Kuhl H., Reinhardt R., Adrian L. Nat. Biotechnol. 23:1269-1273(2005) [PubMed: 16116419] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CBDB1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ965256 Genomic DNA. Translation: CAI82623.1.
RefSeq	YP_307539.1. NC_007356.1.
3D structure databases
ProteinModelPortal	Q3ZZJ0.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3ZZJ0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3622681.
GenomeReviews	Gene locus cbdbA419 in contig AJ965256_GR.
KEGG	deh:cbdb_A419.
NMPDR	fig|255470.3.peg.866.
PATRIC	21611003. VBIDehSp125902_0347.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0061.
HOGENOM	HBG713904.
OMA	LLHLKNY.
PhylomeDB	Q3ZZJ0.
ProtClustDB	CLSK2767674.
Enzyme and pathway databases
BioCyc	DSP255470:CBDBA419-MONOMER.
Family and domain databases
HAMAP	MF_00361. NAD_kinase. [Tree]
InterPro	IPR016064. ATP-NAD_kinase_PpnK-typ. IPR017438. ATP-NAD_kinase_PpnK-typ_a/b. IPR017437. ATP-NAD_kinase_PpnK-typ_all-b. IPR002504. polyP/ATP_NADK_prd. [Graphical view]
Gene3D	G3DSA:2.60.200.30. ATP-NAD_kinase_PpnK-typ. 1 hit. G3DSA:3.40.50.10330. ATP-NAD_kinase_PpnK-typ_a/b. 1 hit.
KO	K00858.
PANTHER	PTHR20275. ATP_NADK. 1 hit.
Pfam	PF01513. NAD_kinase. 1 hit. [Graphical view]
SUPFAM	SSF111331. ATP-NAD_kinase_PpnK-typ. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PPNK_DEHSC

Accession

Primary (citable) accession number: Q3ZZJ0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	September 27, 2005
Last modified:	January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program