ID   RNPH_DEHSC              Reviewed;         241 AA.
AC   Q3ZYH8;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   16-JUN-2009, entry version 26.
DE   RecName: Full=Ribonuclease PH;
DE            Short=RNase PH;
DE            EC=2.7.7.56;
DE   AltName: Full=tRNA nucleotidyltransferase;
GN   Name=rph; OrderedLocusNames=cbdbA1225;
OS   Dehalococcoides sp. (strain CBDB1).
OC   Bacteria; Chloroflexi; Dehalococcoidetes; Dehalococcoides.
OX   NCBI_TaxID=255470;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16116419; DOI=10.1038/nbt1131;
RA   Kube M., Beck A., Zinder S.H., Kuhl H., Reinhardt R., Adrian L.;
RT   "Genome sequence of the chlorinated compound-respiring bacterium
RT   Dehalococcoides species strain CBDB1.";
RL   Nat. Biotechnol. 23:1269-1273(2005).
CC   -!- FUNCTION: Phosphorolytic exoribonuclease that removes nucleotide
CC       residues following the -CCA terminus of tRNA and adds nucleotides
CC       to the ends of RNA molecules by using nucleoside diphosphates as
CC       substrates (By similarity).
CC   -!- CATALYTIC ACTIVITY: tRNA(n+1) + phosphate = tRNA(n) + a nucleoside
CC       diphosphate.
CC   -!- SIMILARITY: Belongs to the RNase PH family.
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DR   EMBL; AJ965256; CAI83296.1; -; Genomic_DNA.
DR   RefSeq; YP_308212.1; -.
DR   GeneID; 3623385; -.
DR   GenomeReviews; AJ965256_GR; cbdbA1225.
DR   KEGG; deh:cbdb_A1225; -.
DR   NMPDR; fig|255470.3.peg.1003; -.
DR   HOGENOM; Q3ZYH8; -.
DR   OMA; Q3ZYH8; YAMLPRA.
DR   BioCyc; DSP255470:CBDBA1225-MON; -.
DR   GO; GO:0000175; F:3'-5'-exoribonuclease activity; IEA:InterPro.
DR   GO; GO:0000049; F:tRNA binding; IEA:HAMAP.
DR   GO; GO:0009022; F:tRNA nucleotidyltransferase activity; IEA:HAMAP.
DR   GO; GO:0004549; F:tRNA-specific ribonuclease activity; IEA:InterPro.
DR   GO; GO:0008033; P:tRNA processing; IEA:HAMAP.
DR   HAMAP; MF_00564; -; 1.
DR   InterPro; IPR001247; ExoRNase_PH_dom1.
DR   InterPro; IPR015847; ExoRNase_PH_dom2.
DR   InterPro; IPR018336; Ribonuclease-PH_CS.
DR   InterPro; IPR002381; RNase_PH_bac-type.
DR   Pfam; PF01138; RNase_PH; 1.
DR   Pfam; PF03725; RNase_PH_C; 1.
DR   TIGRFAMs; TIGR01966; RNasePH; 1.
DR   PROSITE; PS01277; RIBONUCLEASE_PH; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Nucleotidyltransferase; Transferase;
KW   tRNA processing.
FT   CHAIN         1    241       Ribonuclease PH.
FT                                /FTId=PRO_1000061132.
SQ   SEQUENCE   241 AA;  26556 MW;  E7EDE4931AA9EDEC CRC64;
     MQRGDGRNFN QLRPITITPG FQSFAEGSVL IEQGKTRVIC SVSMEDRVPQ FLRNSGTGWV
     TAEYSMLPRS TVTRTQRDSS AGKISGRSQE IQRLIGRSLR SCVDMAALGE RSFIVDCDVI
     QADAGTRTAS ITGSYIALYL AFKKMVDMGI LSKMPFTSQV AAVSVSIFKG NIVLDPCYDE
     DFQAEVDFNL VMNDRGEFVE IQGTAEGKAF SRDTLDQVLK LGEAGIRQLF DIQKGITQPQ
     L
//