ID   GCH1_DEHSC              Reviewed;         189 AA.
AC   Q3ZYB5;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   16-JUN-2009, entry version 28.
DE   RecName: Full=GTP cyclohydrolase 1;
DE            EC=3.5.4.16;
DE   AltName: Full=GTP cyclohydrolase I;
DE            Short=GTP-CH-I;
GN   Name=folE; OrderedLocusNames=cbdbA1120;
OS   Dehalococcoides sp. (strain CBDB1).
OC   Bacteria; Chloroflexi; Dehalococcoidetes; Dehalococcoides.
OX   NCBI_TaxID=255470;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16116419; DOI=10.1038/nbt1131;
RA   Kube M., Beck A., Zinder S.H., Kuhl H., Reinhardt R., Adrian L.;
RT   "Genome sequence of the chlorinated compound-respiring bacterium
RT   Dehalococcoides species strain CBDB1.";
RL   Nat. Biotechnol. 23:1269-1273(2005).
CC   -!- CATALYTIC ACTIVITY: GTP + H(2)O = formate + 2-amino-4-hydroxy-6-
CC       (erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.
CC   -!- PATHWAY: Cofactor biosynthesis; dihydroneopterin triphosphate
CC       biosynthesis; 2-amino-4-hydroxy-6-(erythro-1,2,3-
CC       trihydroxypropyl)-dihydropteridine triphosphate from GTP: step
CC       1/1.
CC   -!- SUBUNIT: Toroid-shaped homodecamer, composed of two pentamers of
CC       five dimers (By similarity).
CC   -!- SIMILARITY: Belongs to the GTP cyclohydrolase I family.
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DR   EMBL; AJ965256; CAI83216.1; -; Genomic_DNA.
DR   RefSeq; YP_308132.1; -.
DR   GeneID; 3622836; -.
DR   GenomeReviews; AJ965256_GR; cbdbA1120.
DR   KEGG; deh:cbdb_A1120; -.
DR   NMPDR; fig|255470.3.peg.805; -.
DR   HOGENOM; Q3ZYB5; -.
DR   OMA; Q3ZYB5; ARIVEMF.
DR   BioCyc; DSP255470:CBDBA1120-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003934; F:GTP cyclohydrolase I activity; IEA:HAMAP.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006730; P:one-carbon compound metabolic process; IEA:HAMAP.
DR   GO; GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00223; -; 1.
DR   InterPro; IPR001474; GTP_CycHdrlase_I.
DR   InterPro; IPR018234; GTP_CycHdrlase_I_CS.
DR   PANTHER; PTHR11109; GTP_cyclohydro_I; 1.
DR   Pfam; PF01227; GTP_cyclohydroI; 1.
DR   ProDom; PD003330; GTP_cyclohydroI; 1.
DR   TIGRFAMs; TIGR00063; folE; 1.
DR   PROSITE; PS00859; GTP_CYCLOHYDROL_1_1; 1.
DR   PROSITE; PS00860; GTP_CYCLOHYDROL_1_2; FALSE_NEG.
PE   3: Inferred from homology;
KW   Complete proteome; GTP-binding; Hydrolase; Metal-binding;
KW   Nucleotide-binding; One-carbon metabolism; Zinc.
FT   CHAIN         1    189       GTP cyclohydrolase 1.
FT                                /FTId=PRO_1000043688.
FT   METAL        76     76       Zinc (By similarity).
FT   METAL        79     79       Zinc (By similarity).
FT   METAL       149    149       Zinc (By similarity).
SQ   SEQUENCE   189 AA;  21101 MW;  7B550F6EAC52AD89 CRC64;
     MFDEQAIKQS VQNILVAIGE DPDREGLKET PRRVAQMYTE LFSGMNQDPA EVLRVGYELG
     HREMVIIKDI PFYSMCEHHL LPFSGVVHIG YIPNIDGRVV GISKLARVVE IYAKRPQIQE
     RMATQIADAI MDGLKCDGVA VVIEAEHMCM VMRGIKKPGS RVITSALRGS FHKSPAARAE
     FLSLIQHKG
//