Q3ZY97 (PYRB_DEHSC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate carbamoyltransferase
EC=2.1.3.2

Alternative name(s):
Aspartate transcarbamylase
Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	cbdbA1113

Organism

Dehalococcoides sp. (strain CBDB1) [Complete proteome] [HAMAP]

Taxonomic identifier

255470 [NCBI]

Taxonomic lineage

Bacteria › Chloroflexi › Dehalococcoidetes › Dehalococcoides

Protein attributes

Sequence length	331 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 331	331	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_0000321096

Sequences

	Sequence		Length	Mass (Da)
	Q3ZY97 [UniParc]. Last modified September 27, 2005. Version 1. Checksum: 818AA3814723D8AA	FASTA	331	36,364
	10 20 30 40 50 60 MTHIPKTPAD TETLLSEVQG WKHRHVLDLD NFSREELDMV MQTAGVMLDI LSRPVKKVPA 70 80 90 100 110 120 LKGKTIATLF YEPSTRTRSS FELAAKSLSA DVLNLNVSQS SISKGESLLD TLDTLESLGA 130 140 150 160 170 180 DMVVMRHPLS GAPYLAANNC HANIINAGDG WHAHPSQALL DIFTILRHKS SLEGLKITLI 190 200 210 220 230 240 GDIKHSRVAH SNIWGLSKMG AKITLCAPYT LLPEGLNTNS KIFPEVTLET DIKQAVSGAD 250 260 270 280 290 300 VVMGLRLQRE RQQSGLLPGI REYARYFQLN EEILKLAKPN SLVMHPGPVN EDIELSQSVV 310 320 330 HGEQSVINEQ VKNGVAVRMA LFYLCSGSKE I

References

[1]

"Genome sequence of the chlorinated compound-respiring bacterium Dehalococcoides species strain CBDB1." Kube M., Beck A., Zinder S.H., Kuhl H., Reinhardt R., Adrian L. Nat. Biotechnol. 23:1269-1273(2005) [PubMed: 16116419] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CBDB1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ965256 Genomic DNA. Translation: CAI83211.1.
RefSeq	YP_308127.1. NC_007356.1.
3D structure databases
HSSP	HSSP built from PDB template 2AIR based on UniProtKB P0A786.
ProteinModelPortal	Q3ZY97.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3ZY97.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3623672.
GenomeReviews	Gene locus cbdbA1113 in contig AJ965256_GR.
KEGG	deh:cbdb_A1113.
NMPDR	fig|255470.3.peg.800.
PATRIC	21612243. VBIDehSp125902_0939.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0540.
HOGENOM	HBG579429.
OMA	HANIINA.
PhylomeDB	Q3ZY97.
ProtClustDB	PRK00856.
Enzyme and pathway databases
BioCyc	DSP255470:CBDBA1113-MONOMER.
Family and domain databases
HAMAP	MF_00001. Asp_carb_tr. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002082. Asp_carbamoyltransf_euk. [Graphical view]
KO	K00609.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00670. Asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_DEHSC

Accession

Primary (citable) accession number: Q3ZY97

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	September 27, 2005
Last modified:	January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program