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Q3ZXV6

- PNP_DEHMC

UniProt

Q3ZXV6 - PNP_DEHMC

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Protein
Polyribonucleotide nucleotidyltransferase
Gene
pnp, cbdbA932
Organism
Dehalococcoides mccartyi (strain CBDB1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi484 – 4841Magnesium By similarity
Metal bindingi490 – 4901Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. RNA binding Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. RNA processing Source: InterPro
  2. mRNA catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciDSP255470:GJXW-808-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:cbdbA932
OrganismiDehalococcoides mccartyi (strain CBDB1)
Taxonomic identifieri255470 [NCBI]
Taxonomic lineageiBacteriaChloroflexiDehalococcoidiaDehalococcoidalesDehalococcoidaceaeDehalococcoides
ProteomesiUP000000433: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 720720Polyribonucleotide nucleotidyltransferaseUniRule annotation
PRO_0000329619Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi255470.cbdb_A932.

Structurei

3D structure databases

ProteinModelPortaliQ3ZXV6.
SMRiQ3ZXV6. Positions 616-686.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini551 – 61060KH
Add
BLAST
Domaini620 – 68869S1 motif
Add
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
KOiK00962.
OMAiGTENTIC.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3ZXV6-1 [UniParc]FASTAAdd to Basket

« Hide

MITANSFERT IGGRKLVIES GKLARLADAA ITIRYADTEL LVTLCSAKKP    50
REGVDFLPLT IDYEERMYAA GKIPGGFIRR EGRPSEQAIL AGRLTDRPLR 100
PLLPKEWRND LQIIITVIAS DKENDADIWG VVGASTVLAM SEIPYEGPVG 150
ASRIGYINGE FVLNPTFAQL ESSQLDLVVV STRKAVVMIE AGSKEIPEDI 200
MINAIEFAHK ANQELIDLQD EIRAKLGKEK LPVPVLEIPE EVKTAVAAFV 250
KGRVNEALSH QDKTARENAV EGLQAELVAA LSETFAEGDI LAAYDKEIKK 300
AIRSTILEKD IRVNGRGIKQ LRQLDAETGL LPRVHGSALF TRGDTQVMAI 350
TTLGSLQESQ QLDGLSAEDT KRFMLHYNFA PFSTGEVKRS GSPGRREIGH 400
GALAERALVP VLPTPEEFPY TIRLVADVVG SSGSTSMGSV CSSSLSLMDA 450
GVPVKKAVAG ISIGLITGEN DTYCTITDIE GIEDNYGDMD FKVAGTRDGI 500
TAIQVDMKVK GISFDIIRDA IYQAKEARYN ILDVMDKALA QPKTELSPYA 550
PRMYKINIDP SKIGSVIGSG GKTIRSIIEQ TNTTVDIEND GTVVIGATDE 600
ASAKKAIKII EDLTKDIEAG SIYTGKVTRI MTFGAFVEIL PGKEGMVHIS 650
ELADHRVEKV EDIVKVGDDI TVKVIEIDNQ GRVNLSHRVI LNPNAVPISR 700
NRDSQPRRPG PFRPSDRSNS 720
Length:720
Mass (Da):78,329
Last modified:September 27, 2005 - v1
Checksum:i3AEDF75BF5F17B8A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ965256 Genomic DNA. Translation: CAI83060.1.
RefSeqiYP_307976.1. NC_007356.1.

Genome annotation databases

EnsemblBacteriaiCAI83060; CAI83060; cbdbA932.
GeneIDi3623977.
KEGGideh:cbdb_A932.
PATRICi21611925. VBIDehSp125902_0789.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ965256 Genomic DNA. Translation: CAI83060.1 .
RefSeqi YP_307976.1. NC_007356.1.

3D structure databases

ProteinModelPortali Q3ZXV6.
SMRi Q3ZXV6. Positions 616-686.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 255470.cbdb_A932.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAI83060 ; CAI83060 ; cbdbA932 .
GeneIDi 3623977.
KEGGi deh:cbdb_A932.
PATRICi 21611925. VBIDehSp125902_0789.

Phylogenomic databases

eggNOGi COG1185.
KOi K00962.
OMAi GTENTIC.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci DSP255470:GJXW-808-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the chlorinated compound-respiring bacterium Dehalococcoides species strain CBDB1."
    Kube M., Beck A., Zinder S.H., Kuhl H., Reinhardt R., Adrian L.
    Nat. Biotechnol. 23:1269-1273(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CBDB1.

Entry informationi

Entry nameiPNP_DEHMC
AccessioniPrimary (citable) accession number: Q3ZXV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: September 27, 2005
Last modified: May 14, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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