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Q3ZXV6

- PNP_DEHMC

UniProt

Q3ZXV6 - PNP_DEHMC

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Dehalococcoides mccartyi (strain CBDB1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi484 – 4841MagnesiumUniRule annotation
Metal bindingi490 – 4901MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciDSP255470:GJXW-808-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:cbdbA932
OrganismiDehalococcoides mccartyi (strain CBDB1)
Taxonomic identifieri255470 [NCBI]
Taxonomic lineageiBacteriaChloroflexiDehalococcoidiaDehalococcoidalesDehalococcoidaceaeDehalococcoides
ProteomesiUP000000433: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 720720Polyribonucleotide nucleotidyltransferasePRO_0000329619Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi255470.cbdb_A932.

Structurei

3D structure databases

ProteinModelPortaliQ3ZXV6.
SMRiQ3ZXV6. Positions 616-686.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini551 – 61060KHUniRule annotationAdd
BLAST
Domaini620 – 68869S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
KOiK00962.
OMAiGTENTIC.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3ZXV6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MITANSFERT IGGRKLVIES GKLARLADAA ITIRYADTEL LVTLCSAKKP
60 70 80 90 100
REGVDFLPLT IDYEERMYAA GKIPGGFIRR EGRPSEQAIL AGRLTDRPLR
110 120 130 140 150
PLLPKEWRND LQIIITVIAS DKENDADIWG VVGASTVLAM SEIPYEGPVG
160 170 180 190 200
ASRIGYINGE FVLNPTFAQL ESSQLDLVVV STRKAVVMIE AGSKEIPEDI
210 220 230 240 250
MINAIEFAHK ANQELIDLQD EIRAKLGKEK LPVPVLEIPE EVKTAVAAFV
260 270 280 290 300
KGRVNEALSH QDKTARENAV EGLQAELVAA LSETFAEGDI LAAYDKEIKK
310 320 330 340 350
AIRSTILEKD IRVNGRGIKQ LRQLDAETGL LPRVHGSALF TRGDTQVMAI
360 370 380 390 400
TTLGSLQESQ QLDGLSAEDT KRFMLHYNFA PFSTGEVKRS GSPGRREIGH
410 420 430 440 450
GALAERALVP VLPTPEEFPY TIRLVADVVG SSGSTSMGSV CSSSLSLMDA
460 470 480 490 500
GVPVKKAVAG ISIGLITGEN DTYCTITDIE GIEDNYGDMD FKVAGTRDGI
510 520 530 540 550
TAIQVDMKVK GISFDIIRDA IYQAKEARYN ILDVMDKALA QPKTELSPYA
560 570 580 590 600
PRMYKINIDP SKIGSVIGSG GKTIRSIIEQ TNTTVDIEND GTVVIGATDE
610 620 630 640 650
ASAKKAIKII EDLTKDIEAG SIYTGKVTRI MTFGAFVEIL PGKEGMVHIS
660 670 680 690 700
ELADHRVEKV EDIVKVGDDI TVKVIEIDNQ GRVNLSHRVI LNPNAVPISR
710 720
NRDSQPRRPG PFRPSDRSNS
Length:720
Mass (Da):78,329
Last modified:September 27, 2005 - v1
Checksum:i3AEDF75BF5F17B8A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ965256 Genomic DNA. Translation: CAI83060.1.
RefSeqiYP_307976.1. NC_007356.1.

Genome annotation databases

EnsemblBacteriaiCAI83060; CAI83060; cbdbA932.
GeneIDi3623977.
KEGGideh:cbdb_A932.
PATRICi21611925. VBIDehSp125902_0789.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ965256 Genomic DNA. Translation: CAI83060.1 .
RefSeqi YP_307976.1. NC_007356.1.

3D structure databases

ProteinModelPortali Q3ZXV6.
SMRi Q3ZXV6. Positions 616-686.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 255470.cbdb_A932.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAI83060 ; CAI83060 ; cbdbA932 .
GeneIDi 3623977.
KEGGi deh:cbdb_A932.
PATRICi 21611925. VBIDehSp125902_0789.

Phylogenomic databases

eggNOGi COG1185.
KOi K00962.
OMAi GTENTIC.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci DSP255470:GJXW-808-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the chlorinated compound-respiring bacterium Dehalococcoides species strain CBDB1."
    Kube M., Beck A., Zinder S.H., Kuhl H., Reinhardt R., Adrian L.
    Nat. Biotechnol. 23:1269-1273(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CBDB1.

Entry informationi

Entry nameiPNP_DEHMC
AccessioniPrimary (citable) accession number: Q3ZXV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: September 27, 2005
Last modified: October 29, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3