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Reviewed, UniProtKB/Swiss-Prot Q3ZXL7 (HISX_DEHSC)

Last modified November 25, 2008. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Histidinol dehydrogenase
      Short name=HDH
    EC=1.1.1.23
Gene names
Name: hisD
Ordered Locus Names: cbdbA826
OrganismDehalococcoides sp. (strain CBDB1) [Complete proteome] [HAMAP]
Taxonomic identifier255470 [NCBI]
Taxonomic lineageBacteria › Chloroflexi › Dehalococcoidetes › Dehalococcoides

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Protein attributes

Sequence length436 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.

Catalytic activity

L-histidinol + 2 NAD(+) = L-histidine + 2 NADH.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.

Sequence similarities

Belongs to the histidinol dehydrogenase family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 436436Histidinol dehydrogenase
PRO_0000135765

Sites

Active site3341Proton acceptor By similarity
Active site3351Proton acceptor By similarity
Metal binding2661Zinc By similarity
Metal binding2691Zinc By similarity
Metal binding3681Zinc By similarity
Metal binding4271Zinc By similarity
Binding site1361NAD By similarity
Binding site1981NAD By similarity
Binding site2211NAD By similarity
Binding site2441Substrate By similarity
Binding site2661Substrate By similarity
Binding site2691Substrate By similarity
Binding site3351Substrate By similarity
Binding site3681Substrate By similarity
Binding site4221Substrate By similarity
Binding site4271Substrate By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q3ZXL7-1 [UniParc].

Last modified September 27, 2005. Version 1.
Checksum: 4FE7208670BA48C6

FASTA43646,942
        10         20         30         40         50         60 
MKIIRGFAQA EKRLSRRDKA GFFLDETERT ELARRLGVDP EKAVNGIIAD VRKQGDEAVL 

        70         80         90        100        110        120 
GYTLKFDRAN LSKLEVGQPE IQQAASEIPA ELFEALQLAA SQIRAYHRFQ KEAVWKTAEI 

       130        140        150        160        170        180 
MQGKQLIRPL ERVGLYVPGG KAFYPSTVLM TAIPAREAGV KEIILVTPPG ANGKIPAPTL 

       190        200        210        220        230        240 
AAAQIAGVDR IFACGGAQAV AALAFGTKSI PKVDKICGPG NIFVTLAKKA VFGVVDIDGL 

       250        260        270        280        290        300 
QGPSEVLIVA DQYANAEYCA SDILAQAEHD ALASSILITT SEDLANRVND IVESKADTCS 

       310        320        330        340        350        360 
RRDIIKQSLR DNGLIAVVDN INEAIKLANM YAAEHLCLLV KDSEKYLTQI NHAGCIFYGE 

       370        380        390        400        410        420 
KASVVMGDYV AGPSHALPTS GTARFSSPLN ILDFVKYIDI VKVDKQDIAK LGQAAATIAK 

       430 
AEGLECHAEA VLKRLE

« Hide

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References

[1]"Genome sequence of the chlorinated compound-respiring bacterium Dehalococcoides species strain CBDB1."
Kube M., Beck A., Zinder S.H., Kuhl H., Reinhardt R., Adrian L.
Nat. Biotechnol. 23:1269-1273(2005) [PubMed: 16116419] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

AJ965256 Genomic DNA. Translation: CAI82971.1.
RefSeqYP_307887.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID3623070.
GenomeReviewsGene locus cbdbA826 in contig AJ965256_GR.
KEGGdeh:cbdb_A826.
NMPDRfig|255470.3.peg.207.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ3ZXL7.

Enzyme and pathway databases

BioCycDSP255470:CBDBA826-MON.

Family and domain databases

HAMAPMF_01024.
[Tree]
InterProIPR001692. Histidinol_DHase.
IPR012131. Hstdl_DHase_prok.
[Graphical view]
PANTHERPTHR21256:SF2. Hstdl_DH_prok. 1 hit.
PfamPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PRINTSPR00083. HOLDHDRGNASE.
ProDomPD002680. Histidinol_dh. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR00069. hisD. 1 hit.
PROSITEPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameHISX_DEHSC
AccessionPrimary (citable) accession number: Q3ZXL7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: September 27, 2005
Last modified: November 25, 2008
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents