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Q3ZXL7

- HISX_DEHMC

UniProt

Q3ZXL7 - HISX_DEHMC

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Protein
Histidinol dehydrogenase
Gene
hisD, cbdbA826
Organism
Dehalococcoides mccartyi (strain CBDB1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei136 – 1361NAD By similarity
Binding sitei198 – 1981NAD By similarity
Binding sitei221 – 2211NAD By similarity
Binding sitei244 – 2441Substrate By similarity
Metal bindingi266 – 2661Zinc By similarity
Binding sitei266 – 2661Substrate By similarity
Metal bindingi269 – 2691Zinc By similarity
Binding sitei269 – 2691Substrate By similarity
Active sitei334 – 3341Proton acceptor By similarity
Active sitei335 – 3351Proton acceptor By similarity
Binding sitei335 – 3351Substrate By similarity
Metal bindingi368 – 3681Zinc By similarity
Binding sitei368 – 3681Substrate By similarity
Binding sitei422 – 4221Substrate By similarity
Metal bindingi427 – 4271Zinc By similarity
Binding sitei427 – 4271Substrate By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciDSP255470:GJXW-715-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:cbdbA826
OrganismiDehalococcoides mccartyi (strain CBDB1)
Taxonomic identifieri255470 [NCBI]
Taxonomic lineageiBacteriaChloroflexiDehalococcoidiaDehalococcoidalesDehalococcoidaceaeDehalococcoides
ProteomesiUP000000433: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 436436Histidinol dehydrogenaseUniRule annotation
PRO_0000135765Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi255470.cbdb_A826.

Structurei

3D structure databases

ProteinModelPortaliQ3ZXL7.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
KOiK00013.
OMAiICGPGNK.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3ZXL7-1 [UniParc]FASTAAdd to Basket

« Hide

MKIIRGFAQA EKRLSRRDKA GFFLDETERT ELARRLGVDP EKAVNGIIAD    50
VRKQGDEAVL GYTLKFDRAN LSKLEVGQPE IQQAASEIPA ELFEALQLAA 100
SQIRAYHRFQ KEAVWKTAEI MQGKQLIRPL ERVGLYVPGG KAFYPSTVLM 150
TAIPAREAGV KEIILVTPPG ANGKIPAPTL AAAQIAGVDR IFACGGAQAV 200
AALAFGTKSI PKVDKICGPG NIFVTLAKKA VFGVVDIDGL QGPSEVLIVA 250
DQYANAEYCA SDILAQAEHD ALASSILITT SEDLANRVND IVESKADTCS 300
RRDIIKQSLR DNGLIAVVDN INEAIKLANM YAAEHLCLLV KDSEKYLTQI 350
NHAGCIFYGE KASVVMGDYV AGPSHALPTS GTARFSSPLN ILDFVKYIDI 400
VKVDKQDIAK LGQAAATIAK AEGLECHAEA VLKRLE 436
Length:436
Mass (Da):46,942
Last modified:September 27, 2005 - v1
Checksum:i4FE7208670BA48C6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ965256 Genomic DNA. Translation: CAI82971.1.
RefSeqiYP_307887.1. NC_007356.1.

Genome annotation databases

EnsemblBacteriaiCAI82971; CAI82971; cbdbA826.
GeneIDi3623070.
KEGGideh:cbdb_A826.
PATRICi21611735. VBIDehSp125902_0698.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ965256 Genomic DNA. Translation: CAI82971.1 .
RefSeqi YP_307887.1. NC_007356.1.

3D structure databases

ProteinModelPortali Q3ZXL7.
ModBasei Search...

Protein-protein interaction databases

STRINGi 255470.cbdb_A826.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAI82971 ; CAI82971 ; cbdbA826 .
GeneIDi 3623070.
KEGGi deh:cbdb_A826.
PATRICi 21611735. VBIDehSp125902_0698.

Phylogenomic databases

eggNOGi COG0141.
KOi K00013.
OMAi ICGPGNK.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci DSP255470:GJXW-715-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the chlorinated compound-respiring bacterium Dehalococcoides species strain CBDB1."
    Kube M., Beck A., Zinder S.H., Kuhl H., Reinhardt R., Adrian L.
    Nat. Biotechnol. 23:1269-1273(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CBDB1.

Entry informationi

Entry nameiHISX_DEHMC
AccessioniPrimary (citable) accession number: Q3ZXL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: September 27, 2005
Last modified: May 14, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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