Reviewed, UniProtKB/Swiss-Prot Q3ZXH1 (ADEC_DEHSC)

Names and origin

Protein names

Recommended name:
    Adenine deaminase
      Short name=Adenase
      Short name=Adenine aminase
    EC=3.5.4.2

Gene names

Name:	ade
Ordered Locus Names:	cbdbA769

Organism

Dehalococcoides sp. (strain CBDB1) [Complete proteome] [HAMAP]

Taxonomic identifier

255470 [NCBI]

Taxonomic lineage

Bacteria › Chloroflexi › Dehalococcoidetes › Dehalococcoides

Protein attributes

Sequence length	571 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Adenine + H2O = hypoxanthine + NH3. HAMAP MF_01518
Cofactor	Manganese By similarity.
Sequence similarities	Belongs to the adenine deaminase family.

Ontologies

Keywords
Ligand	Manganese
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	adenine catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	adenine deaminase activity Inferred from electronic annotation. Source: HAMAP manganese ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 571	571	Adenine deaminase HAMAP MF_01518		PRO_0000142415

Sequences

	Sequence		Length	Mass (Da)
	Q3ZXH1-1 [UniParc]. Last modified September 27, 2005. Version 1. Checksum: 60199447D7B0CFD5	FASTA	571	61,452
	10 20 30 40 50 60 MQTNLSQLIK VARGETEADL VLLNARVINV FNAEIEQANV AVFDGKIAGV GDYRHGKEVI 70 80 90 100 110 120 DLKGAYLLPG LINGHTHVES SMLDIAQYAR AVVSHGTLAL ITDLHEISNV CGKEGIDYVL 130 140 150 160 170 180 DASADLPLSI FLQVPSCVPA THLETAGAEI NSQDVADLLR LPNVTGLGEM MNFPGVLFGV 190 200 210 220 230 240 PSVLDKIIAA AGKVLDGHAP GLSGKDLNAY ISAGIHSDHE CIHLAEAKEK LARGMYIMIR 250 260 270 280 290 300 EGSSEKNLAE LLPLVTDQTY KRCLFVVDDR SCADLKSDGD IDAVVRKAIR LGLDPVRAIQ 310 320 330 340 350 360 LASINTAEYF HLQGHGAIAP GYLANMIVCQ NLEQLDIDMV FHKGKLVAEK GQALFKPQSR 370 380 390 400 410 420 IPKSLLNSIH IRPFDTKDLI LKTIQPQIPV IEVIPGQIVT RRLDLKIPAE NGVIKANTEL 430 440 450 460 470 480 DLLKIVVMER HHQSGNMGHG LIRGFGLKKG AIASSVAHDS HNVVAVGTND ADLYTAIKEL 490 500 510 520 530 540 ERINGGIALA VDGQVTASVS LPVAGLLSTK PLEEVVTELE EINNQVAKLG CKLSAPFATL 550 560 570 SFMALPVIPE LRLTDLGLVD VKTFKLIPQE T

References

[1]	"Genome sequence of the chlorinated compound-respiring bacterium Dehalococcoides species strain CBDB1." Kube M., Beck A., Zinder S.H., Kuhl H., Reinhardt R., Adrian L. Nat. Biotechnol. 23:1269-1273(2005) [PubMed: 16116419] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ965256 Genomic DNA. Translation: CAI82924.1.
RefSeq	YP_307840.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3623262.
GenomeReviews	Gene locus cbdbA769 in contig AJ965256_GR.
KEGG	deh:cbdb_A769.
NMPDR	fig|255470.3.peg.94.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q3ZXH1.
OMA	Q3ZXH1. IMIREGS.
Enzyme and pathway databases
BioCyc	DSP255470:CBDBA769-MON.
Family and domain databases
HAMAP	MF_01518. [Tree]
InterPro	IPR006679. Adenine_deam. IPR006680. Amidohydro_1. [Graphical view]
Pfam	PF01979. Amidohydro_1. 1 hit. [Graphical view]
ProDom	PD001248. Amidohydro_like. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01178. ade. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ADEC_DEHSC

Accession

Primary (citable) accession number: Q3ZXH1

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	September 27, 2005
Last modified:	May 5, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)