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Q3ZXF9

- PANC_DEHMC

UniProt

Q3ZXF9 - PANC_DEHMC

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Protein

Pantothenate synthetase

Gene

panC

Organism
Dehalococcoides mccartyi (strain CBDB1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei25 – 251Proton donorUniRule annotation
Binding sitei49 – 491Beta-alanineUniRule annotation
Binding sitei49 – 491PantoateUniRule annotation
Binding sitei141 – 1411PantoateUniRule annotation
Binding sitei164 – 1641ATP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi18 – 258ATPUniRule annotation
Nucleotide bindingi135 – 1384ATPUniRule annotation
Nucleotide bindingi172 – 1754ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDSP255470:GJXW-675-MONOMER.
UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
Short name:
PSUniRule annotation
Alternative name(s):
Pantoate--beta-alanine ligaseUniRule annotation
Pantoate-activating enzymeUniRule annotation
Gene namesi
Name:panCUniRule annotation
Ordered Locus Names:cbdbA782
OrganismiDehalococcoides mccartyi (strain CBDB1)
Taxonomic identifieri255470 [NCBI]
Taxonomic lineageiBacteriaChloroflexiDehalococcoidiaDehalococcoidalesDehalococcoidaceaeDehalococcoides
ProteomesiUP000000433: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 268268Pantothenate synthetasePRO_0000305436Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi255470.cbdb_A782.

Structurei

3D structure databases

ProteinModelPortaliQ3ZXF9.
SMRiQ3ZXF9. Positions 8-268.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pantothenate synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0414.
KOiK01918.
OMAiGDGHETW.
OrthoDBiEOG6Z6FZ4.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
InterProiIPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3ZXF9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKKLHREICG PVGLVPTMGY LHEGHLSLVR ASKKQDINTV ASIFVNPTQF
60 70 80 90 100
GPHEDFKKYP RDEKRDMAML ENTGVDYVFV PSVEDMYPAG FDSWVEPGIL
110 120 130 140 150
QQCLEGAVRP GHFRGVCTVV AKLFTIIRPD RAYFGQKDYQ QYLIIKRMAS
160 170 180 190 200
DLNLDVSVEM LPIIRENDGL ALSSRNTYLS PAERQAALVL YRSLLTARSL
210 220 230 240 250
FDEKEHRAEV IRKKMTDVIQ HESMAEIDYV SLSHQDTLCE SDEVSAKTIA
260
LVAARFGKTR LIDNMFLA
Length:268
Mass (Da):30,386
Last modified:September 27, 2005 - v1
Checksum:iA33EE7CB26AE51E5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ965256 Genomic DNA. Translation: CAI82936.1.
RefSeqiWP_011309287.1. NC_007356.1.
YP_307852.1. NC_007356.1.

Genome annotation databases

EnsemblBacteriaiCAI82936; CAI82936; cbdbA782.
GeneIDi3623296.
KEGGideh:cbdb_A782.
PATRICi21611655. VBIDehSp125902_0663.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ965256 Genomic DNA. Translation: CAI82936.1 .
RefSeqi WP_011309287.1. NC_007356.1.
YP_307852.1. NC_007356.1.

3D structure databases

ProteinModelPortali Q3ZXF9.
SMRi Q3ZXF9. Positions 8-268.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 255470.cbdb_A782.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAI82936 ; CAI82936 ; cbdbA782 .
GeneIDi 3623296.
KEGGi deh:cbdb_A782.
PATRICi 21611655. VBIDehSp125902_0663.

Phylogenomic databases

eggNOGi COG0414.
KOi K01918.
OMAi GDGHETW.
OrthoDBi EOG6Z6FZ4.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00005 .
BioCyci DSP255470:GJXW-675-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00158. PanC.
InterProi IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR21299:SF1. PTHR21299:SF1. 1 hit.
Pfami PF02569. Pantoate_ligase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00018. panC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the chlorinated compound-respiring bacterium Dehalococcoides species strain CBDB1."
    Kube M., Beck A., Zinder S.H., Kuhl H., Reinhardt R., Adrian L.
    Nat. Biotechnol. 23:1269-1273(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CBDB1.

Entry informationi

Entry nameiPANC_DEHMC
AccessioniPrimary (citable) accession number: Q3ZXF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: September 27, 2005
Last modified: October 29, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3