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Q3ZXC2 (DXS_DEHSC) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
1-deoxy-D-xylulose-5-phosphate synthase
EC=2.2.1.7
Alternative name(s):
1-deoxyxylulose-5-phosphate synthase
Short name=DXP synthase
Short name=DXPS
Gene names
Name:dxs
Ordered Locus Names:cbdbA720
OrganismDehalococcoides sp. (strain CBDB1) [Complete proteome] [HAMAP]
Taxonomic identifier255470 [NCBI]
Taxonomic lineageBacteria › Chloroflexi › Dehalococcoidetes › Dehalococcoidales › Dehalococcoidaceae › Dehalococcoides ›

Protein attributes

Sequence length647 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity. HAMAP-Rule MF_00315

Catalytic activity

Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP-Rule MF_00315

Cofactor

Binds 1 magnesium ion per subunit By similarity.

Binds 1 thiamine pyrophosphate per subunit By similarity.

Pathway

Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP-Rule MF_00315

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the transketolase family. DXPS subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 6476471-deoxy-D-xylulose-5-phosphate synthase HAMAP-Rule MF_00315
PRO_0000256409

Regions

Region129 – 1313Thiamine pyrophosphate binding By similarity
Region161 – 1622Thiamine pyrophosphate binding By similarity

Sites

Metal binding1601Magnesium By similarity
Metal binding1891Magnesium By similarity
Binding site881Thiamine pyrophosphate By similarity
Binding site1891Thiamine pyrophosphate By similarity
Binding site3001Thiamine pyrophosphate By similarity
Binding site3771Thiamine pyrophosphate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3ZXC2 [UniParc].

Last modified September 27, 2005. Version 1.
Checksum: F4C1160B614CABC7

FASTA64770,076
        10         20         30         40         50         60 
MNTGLEISIL HNLEMSKLLD TINSPSDLKK LSLDELRELA VQIREELVNR VTLNGGHLAS 

        70         80         90        100        110        120 
SLGVVELTIA LHRVFESPKD KIIWDVGHQS YAHKLLTGRR EQFATLRQHG GLSGFTCRDE 

       130        140        150        160        170        180 
SPHDPFGAGH ASTSISAGLG MAVARDLAKE DYSVISVIGD GAISGGMSFE AINNAGHLHT 

       190        200        210        220        230        240 
KFIVILNDNG MAISPSTGAL SKFLNNVRFD PRFEFAKRNA KQTITNMPFG KAVWAFTKSI 

       250        260        270        280        290        300 
KRKFEKSMLP GSLWEELGFI YLGPVDGHNI RELEAALKRA KDFESKPVLI HMITKKGKGY 

       310        320        330        340        350        360 
DDAEADAVKY HGISPKSGGL KSSHGLSYSQ VFGQTLHKIM SQNPQVVAIT AAMTDGCGLG 

       370        380        390        400        410        420 
EIAAAFPDRV FDVGICEQHA VTFAAGMATQ GYIPVVVIYS TFLQRGFDQI IHDVCLQKLP 

       430        440        450        460        470        480 
VVFAIDRGGI VGDDGKTHQG IFDLSFMSLI PDMVVSAPSD ENDLQHLIYT AVNSGKPFAL 

       490        500        510        520        530        540 
RYPRGFGEGA EIESSLHNIP IGQNEILVNG SDVAILATGK SVAFAKDALE ILTESGIKPT 

       550        560        570        580        590        600 
LVNNRYISPL DSELVLKIAQ SHKYLVTVEE NVISGGLGSR INTLLAEAGL VNKIKIANIG 

       610        620        630        640 
IPDKFVEHGN QSLLRAKYGL DGKGIAQRVL SLVGNPNEMK HPQIICP

« Hide

References

[1]"Genome sequence of the chlorinated compound-respiring bacterium Dehalococcoides species strain CBDB1."
Kube M., Beck A., Zinder S.H., Kuhl H., Reinhardt R., Adrian L.
Nat. Biotechnol. 23:1269-1273(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CBDB1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AJ965256 Genomic DNA. Translation: CAI82881.1.
RefSeqYP_307797.1. NC_007356.1.

3D structure databases

ProteinModelPortalQ3ZXC2.
ModBaseSearch...

Protein-protein interaction databases

STRING255470.cbdb_A720.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAI82881; CAI82881; cbdbA720.
GeneID3623188.
KEGGdeh:cbdb_A720.
PATRIC21611541. VBIDehSp125902_0609.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1154.
KOK01662.
OMAPVAYHGP.
ProtClustDBPRK05444.

Enzyme and pathway databases

BioCycDSP255470:GJXW-617-MONOMER.
UniPathwayUPA00064; UER00091.

Family and domain databases

Gene3D3.40.50.920. 1 hit.
HAMAPMF_00315. DXP_synth.
InterProIPR005477. Dxylulose-5-P_synthase.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR015941. Transketolase-like_C.
IPR005475. Transketolase-like_Pyr-bd.
IPR005476. Transketolase_C.
IPR005474. Transketolase_N.
[Graphical view]
PfamPF13292. DXP_synthase_N. 1 hit.
PF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view]
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMSSF52922. Transketo_C_like. 1 hit.
TIGRFAMsTIGR00204. dxs. 1 hit.
PROSITEPS00801. TRANSKETOLASE_1. 1 hit.
PS00802. TRANSKETOLASE_2. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDXS_DEHSC
AccessionPrimary (citable) accession number: Q3ZXC2
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: September 27, 2005
Last modified: May 1, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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