Q3ZX40 (FTHS_DEHSC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Formate--tetrahydrofolate ligase
EC=6.3.4.3

Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS

Gene names

Name:	fhs
Ordered Locus Names:	cbdbA660

Organism

Dehalococcoides sp. (strain CBDB1) [Complete proteome] [HAMAP]

Taxonomic identifier

255470 [NCBI]

Taxonomic lineage

Bacteria › Chloroflexi › Dehalococcoidetes › Dehalococcoides

Protein attributes

Sequence length	597 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP MF_01543
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_01543
Sequence similarities	Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	folic acid-containing compound biosynthetic process Inferred from electronic annotation. Source: InterPro one-carbon metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW formate-tetrahydrofolate ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 597	597	Formate--tetrahydrofolate ligase HAMAP MF_01543		PRO_0000199345
Regions
	Nucleotide binding	84 – 91	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3ZX40 [UniParc]. Last modified September 27, 2005. Version 1. Checksum: 775FDB2876B52CB5	FASTA	597	64,493
	10 20 30 40 50 60 MAVNDREFHL KELDPVLMKD WEIAEKAEDF LKPVKVLAME LGLTEDEIIP HGKYIAKVDF 70 80 90 100 110 120 AGVLARLKDR PNGKYIDVTA ITPTPLGEGK STTTMGLVQG LGKLGKKVTG AIRQPSSGPT 130 140 150 160 170 180 FNIKGSAAGG GLSQCLPLSP FSLGLTGDID AVTNSHNLAM VALQARLQHE ANNTDEFLSS 190 200 210 220 230 240 RHLTRLDIDP SRVEMKWAMD FCAQSLREII MGIGGKTDGY RMPSGFGISV SSEVMAILSV 250 260 270 280 290 300 FTSLSDLRER MGKIIVAYRK NDEPVTTADL EVDGAMTALL LRAVNPNLLQ TIEGQPVFVH 310 320 330 340 350 360 AGPFANIAIG QSSIVADRLA LKLADYHVTE SGFGADIGFE KFWNIKCRLS GLKPDCAVIV 370 380 390 400 410 420 VTARALKMHG GGPKVTPGAP LDPAYTTPNT KLVEKGCQNM LAHIQTVKTA GINPVVCINH 430 440 450 460 470 480 FAADTHEEID IIRRTAEQAE ARVAVSHHWA KGGDGATELA EAVTDACNEP NNFHFLYPEN 490 500 510 520 530 540 MPLKKRIETI ARKVYGANGV SYTPIAMEKL ARIESMGDTQ FMPTCMVKTH LSLSHDPALK 550 560 570 580 590 GRPSGFTLPI RDILTYMGAG LVVPVAGDIK LMPGTSSDPN FKRIDVDTQT GKVKGLF

References

[1]

"Genome sequence of the chlorinated compound-respiring bacterium Dehalococcoides species strain CBDB1." Kube M., Beck A., Zinder S.H., Kuhl H., Reinhardt R., Adrian L. Nat. Biotechnol. 23:1269-1273(2005) [PubMed: 16116419] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CBDB1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ965256 Genomic DNA. Translation: CAI82827.1.
RefSeq	YP_307743.1. NC_007356.1.
3D structure databases
ProteinModelPortal	Q3ZX40.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3ZX40.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3623295.
GenomeReviews	Gene locus cbdbA660 in contig AJ965256_GR.
KEGG	deh:cbdb_A660.
NMPDR	fig|255470.3.peg.1348.
PATRIC	21611425. VBIDehSp125902_0557.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2759.
HOGENOM	HBG677721.
OMA	EIMAVLC.
PhylomeDB	Q3ZX40.
ProtClustDB	PRK13507.
Enzyme and pathway databases
BioCyc	DSP255470:CBDBA660-MONOMER.
Family and domain databases
HAMAP	MF_01543. FTHFS. [Tree]
InterPro	IPR000559. Formate_THF_ligase. IPR020628. Formate_THF_ligase_CS. [Graphical view]
KO	K01938.
Pfam	PF01268. FTHFS. 1 hit. [Graphical view]
PROSITE	PS00721. FTHFS_1. 1 hit. PS00722. FTHFS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FTHS_DEHSC

Accession

Primary (citable) accession number: Q3ZX40

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	September 27, 2005
Last modified:	January 25, 2012
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program