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Q3ZX40 (FTHS_DEHMC) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:cbdbA660
OrganismDehalococcoides mccartyi (strain CBDB1) [Complete proteome] [HAMAP]
Taxonomic identifier255470 [NCBI]
Taxonomic lineageBacteriaChloroflexiDehalococcoidiaDehalococcoidalesDehalococcoidaceaeDehalococcoides

Protein attributes

Sequence length597 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 597597Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000199345

Regions

Nucleotide binding84 – 918ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3ZX40 [UniParc].

Last modified September 27, 2005. Version 1.
Checksum: 775FDB2876B52CB5

FASTA59764,493
        10         20         30         40         50         60 
MAVNDREFHL KELDPVLMKD WEIAEKAEDF LKPVKVLAME LGLTEDEIIP HGKYIAKVDF 

        70         80         90        100        110        120 
AGVLARLKDR PNGKYIDVTA ITPTPLGEGK STTTMGLVQG LGKLGKKVTG AIRQPSSGPT 

       130        140        150        160        170        180 
FNIKGSAAGG GLSQCLPLSP FSLGLTGDID AVTNSHNLAM VALQARLQHE ANNTDEFLSS 

       190        200        210        220        230        240 
RHLTRLDIDP SRVEMKWAMD FCAQSLREII MGIGGKTDGY RMPSGFGISV SSEVMAILSV 

       250        260        270        280        290        300 
FTSLSDLRER MGKIIVAYRK NDEPVTTADL EVDGAMTALL LRAVNPNLLQ TIEGQPVFVH 

       310        320        330        340        350        360 
AGPFANIAIG QSSIVADRLA LKLADYHVTE SGFGADIGFE KFWNIKCRLS GLKPDCAVIV 

       370        380        390        400        410        420 
VTARALKMHG GGPKVTPGAP LDPAYTTPNT KLVEKGCQNM LAHIQTVKTA GINPVVCINH 

       430        440        450        460        470        480 
FAADTHEEID IIRRTAEQAE ARVAVSHHWA KGGDGATELA EAVTDACNEP NNFHFLYPEN 

       490        500        510        520        530        540 
MPLKKRIETI ARKVYGANGV SYTPIAMEKL ARIESMGDTQ FMPTCMVKTH LSLSHDPALK 

       550        560        570        580        590 
GRPSGFTLPI RDILTYMGAG LVVPVAGDIK LMPGTSSDPN FKRIDVDTQT GKVKGLF 

« Hide

References

[1]"Genome sequence of the chlorinated compound-respiring bacterium Dehalococcoides species strain CBDB1."
Kube M., Beck A., Zinder S.H., Kuhl H., Reinhardt R., Adrian L.
Nat. Biotechnol. 23:1269-1273(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CBDB1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ965256 Genomic DNA. Translation: CAI82827.1.
RefSeqYP_307743.1. NC_007356.1.

3D structure databases

ProteinModelPortalQ3ZX40.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING255470.cbdb_A660.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAI82827; CAI82827; cbdbA660.
GeneID3623295.
KEGGdeh:cbdb_A660.
PATRIC21611425. VBIDehSp125902_0557.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
KOK01938.
OMAGIEHEAS.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

BioCycDSP255470:GJXW-557-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_DEHMC
AccessionPrimary (citable) accession number: Q3ZX40
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: September 27, 2005
Last modified: May 14, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways