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Q3ZX40

- FTHS_DEHMC

UniProt

Q3ZX40 - FTHS_DEHMC

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Dehalococcoides mccartyi (strain CBDB1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi84 – 918ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDSP255470:GJXW-557-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:cbdbA660
OrganismiDehalococcoides mccartyi (strain CBDB1)
Taxonomic identifieri255470 [NCBI]
Taxonomic lineageiBacteriaChloroflexiDehalococcoidiaDehalococcoidalesDehalococcoidaceaeDehalococcoides
ProteomesiUP000000433: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 597597Formate--tetrahydrofolate ligasePRO_0000199345Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi255470.cbdb_A660.

Structurei

3D structure databases

ProteinModelPortaliQ3ZX40.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
KOiK01938.
OMAiGIEHEAS.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3ZX40-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAVNDREFHL KELDPVLMKD WEIAEKAEDF LKPVKVLAME LGLTEDEIIP
60 70 80 90 100
HGKYIAKVDF AGVLARLKDR PNGKYIDVTA ITPTPLGEGK STTTMGLVQG
110 120 130 140 150
LGKLGKKVTG AIRQPSSGPT FNIKGSAAGG GLSQCLPLSP FSLGLTGDID
160 170 180 190 200
AVTNSHNLAM VALQARLQHE ANNTDEFLSS RHLTRLDIDP SRVEMKWAMD
210 220 230 240 250
FCAQSLREII MGIGGKTDGY RMPSGFGISV SSEVMAILSV FTSLSDLRER
260 270 280 290 300
MGKIIVAYRK NDEPVTTADL EVDGAMTALL LRAVNPNLLQ TIEGQPVFVH
310 320 330 340 350
AGPFANIAIG QSSIVADRLA LKLADYHVTE SGFGADIGFE KFWNIKCRLS
360 370 380 390 400
GLKPDCAVIV VTARALKMHG GGPKVTPGAP LDPAYTTPNT KLVEKGCQNM
410 420 430 440 450
LAHIQTVKTA GINPVVCINH FAADTHEEID IIRRTAEQAE ARVAVSHHWA
460 470 480 490 500
KGGDGATELA EAVTDACNEP NNFHFLYPEN MPLKKRIETI ARKVYGANGV
510 520 530 540 550
SYTPIAMEKL ARIESMGDTQ FMPTCMVKTH LSLSHDPALK GRPSGFTLPI
560 570 580 590
RDILTYMGAG LVVPVAGDIK LMPGTSSDPN FKRIDVDTQT GKVKGLF
Length:597
Mass (Da):64,493
Last modified:September 27, 2005 - v1
Checksum:i775FDB2876B52CB5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ965256 Genomic DNA. Translation: CAI82827.1.
RefSeqiWP_011309178.1. NC_007356.1.
YP_307743.1. NC_007356.1.

Genome annotation databases

EnsemblBacteriaiCAI82827; CAI82827; cbdbA660.
GeneIDi3623295.
KEGGideh:cbdb_A660.
PATRICi21611425. VBIDehSp125902_0557.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ965256 Genomic DNA. Translation: CAI82827.1 .
RefSeqi WP_011309178.1. NC_007356.1.
YP_307743.1. NC_007356.1.

3D structure databases

ProteinModelPortali Q3ZX40.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 255470.cbdb_A660.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAI82827 ; CAI82827 ; cbdbA660 .
GeneIDi 3623295.
KEGGi deh:cbdb_A660.
PATRICi 21611425. VBIDehSp125902_0557.

Phylogenomic databases

eggNOGi COG2759.
KOi K01938.
OMAi GIEHEAS.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci DSP255470:GJXW-557-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the chlorinated compound-respiring bacterium Dehalococcoides species strain CBDB1."
    Kube M., Beck A., Zinder S.H., Kuhl H., Reinhardt R., Adrian L.
    Nat. Biotechnol. 23:1269-1273(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CBDB1.

Entry informationi

Entry nameiFTHS_DEHMC
AccessioniPrimary (citable) accession number: Q3ZX40
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: September 27, 2005
Last modified: November 26, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3