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Q3ZWQ1

- SYL_DEHMC

UniProt

Q3ZWQ1 - SYL_DEHMC

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Protein
Leucine--tRNA ligase
Gene
leuS, cbdbA202
Organism
Dehalococcoides mccartyi (strain CBDB1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei583 – 5831ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDSP255470:GJXW-174-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:cbdbA202
OrganismiDehalococcoides mccartyi (strain CBDB1)
Taxonomic identifieri255470 [NCBI]
Taxonomic lineageiBacteriaChloroflexiDehalococcoidiaDehalococcoidalesDehalococcoidaceaeDehalococcoides
ProteomesiUP000000433: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 813813Leucine--tRNA ligaseUniRule annotation
PRO_1000199194Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi255470.cbdb_A202.

Structurei

3D structure databases

ProteinModelPortaliQ3ZWQ1.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotation
Add
BLAST
Motifi580 – 5845"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
KOiK01869.
OMAiERYWMNV.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3ZWQ1-1 [UniParc]FASTAAdd to Basket

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MAEKYNPQET EKKWQDKWAA DRLYHASEDS PKPKWYSLTM FPYTSGNLHI    50
GHWYAEVPAD CFARYKRLRG FNVMRPVGFD SFGLPAENAA IKHNIHPRIW 100
TLNNVENMRR QLKTIGAMFD WDREVITCLP EYYKWTQWFF LKLYEAGLAY 150
RAKAPVNWCP SCQAVLANEQ VVDGTCWRCE TPTTRRDLEQ WFFRITNYAD 200
ELKDHEGLDW PEKITAMQRN WVGKSYGAEV SFALDCPTAF EKEIKVFTTR 250
PDTIYGVTFM VLAPEHPLVE KITTPENKAA VDAYIKKSRT CTEIERLSTE 300
REKDGVFTGT YVTNRVNGQK VPVWIGDYVL QSYGTGAVMG VPAHDERDFV 350
FAQKYHLPVI TVIAPSEYDG KPLEVAYINE GVMLNSGPFN GTPNTEGKEK 400
VCDYLAEHGW GKKTVNYKLR DWLISRQRYW GAPIPMVYCE KCGIVPVPEK 450
DLPVLLPEDV EFRSGGESPL KYNEGFVNTI CPVCGGKAKR ETDTMDTFMC 500
SSWYFLRYTS PGYDKGPFDP VKLKYWMPVD LYTGGAEHAV MHLFYSRFFT 550
KALRDMGIID FGEPFKKLFN QGIIVSNHQK MSKSKGNVVT PDNLVAEVGT 600
DAVRAYLMFV GPWDQGGEWN DSGLSGMSRW LNRVWNLFTE EYTPQTASAE 650
AERELKRTLH QTIKKITMDI ERLRFNTVVA ALMELSNSLA KLKETAAISA 700
ENWQNTLQTF ALMLAPVAPH IAEELWANLG MKYSIHNQNW PTWDEELAKD 750
EVITLIIQVN GKLRERLEMP AGISEAEAKE TALNSERVKP HLLGKTPVTV 800
IYVPGKLVNI VVK 813
Length:813
Mass (Da):92,974
Last modified:September 27, 2005 - v1
Checksum:iC4AB5C597421734B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ965256 Genomic DNA. Translation: CAI82449.1.
RefSeqiWP_011308807.1. NC_007356.1.
YP_307365.1. NC_007356.1.

Genome annotation databases

EnsemblBacteriaiCAI82449; CAI82449; cbdbA202.
GeneIDi3624004.
KEGGideh:cbdb_A202.
PATRICi21610645. VBIDehSp125902_0171.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ965256 Genomic DNA. Translation: CAI82449.1 .
RefSeqi WP_011308807.1. NC_007356.1.
YP_307365.1. NC_007356.1.

3D structure databases

ProteinModelPortali Q3ZWQ1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 255470.cbdb_A202.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAI82449 ; CAI82449 ; cbdbA202 .
GeneIDi 3624004.
KEGGi deh:cbdb_A202.
PATRICi 21610645. VBIDehSp125902_0171.

Phylogenomic databases

eggNOGi COG0495.
KOi K01869.
OMAi ERYWMNV.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci DSP255470:GJXW-174-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the chlorinated compound-respiring bacterium Dehalococcoides species strain CBDB1."
    Kube M., Beck A., Zinder S.H., Kuhl H., Reinhardt R., Adrian L.
    Nat. Biotechnol. 23:1269-1273(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CBDB1.

Entry informationi

Entry nameiSYL_DEHMC
AccessioniPrimary (citable) accession number: Q3ZWQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: September 27, 2005
Last modified: September 3, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi