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Q3ZWD8

- KGUA_DEHMC

UniProt

Q3ZWD8 - KGUA_DEHMC

Protein

Guanylate kinase

Gene

gmk

Organism
Dehalococcoides mccartyi (strain CBDB1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (27 Sep 2005)
      Previous versions | rss
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    Functioni

    Essential for recycling GMP and indirectly, cGMP.UniRule annotation

    Catalytic activityi

    ATP + GMP = ADP + GDP.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi20 – 278ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. guanylate kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. purine nucleotide metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciDSP255470:GJXW-34-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanylate kinaseUniRule annotation (EC:2.7.4.8UniRule annotation)
    Alternative name(s):
    GMP kinaseUniRule annotation
    Gene namesi
    Name:gmkUniRule annotation
    Ordered Locus Names:cbdbA42
    OrganismiDehalococcoides mccartyi (strain CBDB1)
    Taxonomic identifieri255470 [NCBI]
    Taxonomic lineageiBacteriaChloroflexiDehalococcoidiaDehalococcoidalesDehalococcoidaceaeDehalococcoides
    ProteomesiUP000000433: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 206206Guanylate kinasePRO_0000266315Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi255470.cbdb_A42.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3ZWD8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini13 – 193181Guanylate kinase-likeUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the guanylate kinase family.UniRule annotation
    Contains 1 guanylate kinase-like domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0194.
    KOiK00942.
    OMAiNFLEWEE.
    OrthoDBiEOG6CP410.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_00328. Guanylate_kinase.
    InterProiIPR008145. GK/Ca_channel_bsu.
    IPR008144. Guanylate_kin-like.
    IPR017665. Guanylate_kinase.
    IPR020590. Guanylate_kinase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00625. Guanylate_kin. 1 hit.
    [Graphical view]
    SMARTiSM00072. GuKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR03263. guanyl_kin. 1 hit.
    PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
    PS50052. GUANYLATE_KINASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3ZWD8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMTNWNFNKT EKPLLLIVSG PSGVGKDAVL ARMKERKLPL TYIVTTTTRP    50
    KRETETEGVD YNFIRPAEFQ ELISQNELLE WANVYGNFYG VPKAPIRQAL 100
    SRGSDVIVKV DVQGAASIKK IVPNAVFIFL MPPDMDELTR RLEHRLTESP 150
    ESLRRRLATA PLEIEKLPDF DYVVVNPEGE IDNAVREIMS IIAAEHCRIQ 200
    PRLIEL 206
    Length:206
    Mass (Da):23,431
    Last modified:September 27, 2005 - v1
    Checksum:iEE24834B8C1E8DE0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ965256 Genomic DNA. Translation: CAI82313.1.
    RefSeqiYP_307229.1. NC_007356.1.

    Genome annotation databases

    EnsemblBacteriaiCAI82313; CAI82313; cbdbA42.
    GeneIDi3623609.
    KEGGideh:cbdb_A42.
    PATRICi21610367. VBIDehSp125902_0034.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ965256 Genomic DNA. Translation: CAI82313.1 .
    RefSeqi YP_307229.1. NC_007356.1.

    3D structure databases

    ProteinModelPortali Q3ZWD8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 255470.cbdb_A42.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAI82313 ; CAI82313 ; cbdbA42 .
    GeneIDi 3623609.
    KEGGi deh:cbdb_A42.
    PATRICi 21610367. VBIDehSp125902_0034.

    Phylogenomic databases

    eggNOGi COG0194.
    KOi K00942.
    OMAi NFLEWEE.
    OrthoDBi EOG6CP410.

    Enzyme and pathway databases

    BioCyci DSP255470:GJXW-34-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_00328. Guanylate_kinase.
    InterProi IPR008145. GK/Ca_channel_bsu.
    IPR008144. Guanylate_kin-like.
    IPR017665. Guanylate_kinase.
    IPR020590. Guanylate_kinase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00625. Guanylate_kin. 1 hit.
    [Graphical view ]
    SMARTi SM00072. GuKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR03263. guanyl_kin. 1 hit.
    PROSITEi PS00856. GUANYLATE_KINASE_1. 1 hit.
    PS50052. GUANYLATE_KINASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the chlorinated compound-respiring bacterium Dehalococcoides species strain CBDB1."
      Kube M., Beck A., Zinder S.H., Kuhl H., Reinhardt R., Adrian L.
      Nat. Biotechnol. 23:1269-1273(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CBDB1.

    Entry informationi

    Entry nameiKGUA_DEHMC
    AccessioniPrimary (citable) accession number: Q3ZWD8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: September 27, 2005
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3