Q3ZWD8 (KGUA_DEHSC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Guanylate kinase
EC=2.7.4.8

Alternative name(s):
GMP kinase

Gene names

Name:	gmk
Ordered Locus Names:	cbdbA42

Organism

Dehalococcoides sp. (strain CBDB1) [Complete proteome] [HAMAP]

Taxonomic identifier

255470 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Chloroflexi › Dehalococcoidetes › Dehalococcoidales › Dehalococcoidaceae › Dehalococcoides › Dehalococcoides mccartyi

Protein attributes

Sequence length	206 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Essential for recycling GMP and indirectly, cGMP By similarity. HAMAP-Rule MF_00328
Catalytic activity	ATP + GMP = ADP + GDP. HAMAP-Rule MF_00328
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the guanylate kinase family. Contains 1 guanylate kinase-like domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	purine nucleotide metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW guanylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 206	206	Guanylate kinase HAMAP-Rule MF_00328		PRO_0000266315
Regions
	Domain	13 – 193	181	Guanylate kinase-like
	Nucleotide binding	20 – 27	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3ZWD8 [UniParc]. Last modified September 27, 2005. Version 1. Checksum: EE24834B8C1E8DE0	FASTA	206	23,431
	10 20 30 40 50 60 MMTNWNFNKT EKPLLLIVSG PSGVGKDAVL ARMKERKLPL TYIVTTTTRP KRETETEGVD 70 80 90 100 110 120 YNFIRPAEFQ ELISQNELLE WANVYGNFYG VPKAPIRQAL SRGSDVIVKV DVQGAASIKK 130 140 150 160 170 180 IVPNAVFIFL MPPDMDELTR RLEHRLTESP ESLRRRLATA PLEIEKLPDF DYVVVNPEGE 190 200 IDNAVREIMS IIAAEHCRIQ PRLIEL

References

[1]

"Genome sequence of the chlorinated compound-respiring bacterium Dehalococcoides species strain CBDB1." Kube M., Beck A., Zinder S.H., Kuhl H., Reinhardt R., Adrian L. Nat. Biotechnol. 23:1269-1273(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CBDB1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ965256 Genomic DNA. Translation: CAI82313.1.
RefSeq	YP_307229.1. NC_007356.1.
3D structure databases
HSSP	HSSP built from PDB template 1ZNW based on UniProtKB P0A5I4.
ProteinModelPortal	Q3ZWD8.
ModBase	Search...
Protein-protein interaction databases
STRING	255470.cbdb_A42.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAI82313; CAI82313; cbdbA42.
GeneID	3623609.
KEGG	deh:cbdb_A42.
PATRIC	21610367. VBIDehSp125902_0034.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0194.
KO	K00942.
OMA	EWAEFAG.
ProtClustDB	PRK14738.
Enzyme and pathway databases
BioCyc	DSP255470:GJXW-34-MONOMER.
Family and domain databases
HAMAP	MF_00328. Guanylate_kinase.
InterPro	IPR008144. Guanylate_kin. IPR008145. Guanylate_kin/L-typ_Ca_channel. IPR020590. Guanylate_kinase_CS. IPR017665. Guanylate_kinase_sub. [Graphical view]
Pfam	PF00625. Guanylate_kin. 1 hit. [Graphical view]
SMART	SM00072. GuKc. 1 hit. [Graphical view]
TIGRFAMs	TIGR03263. guanyl_kin. 1 hit.
PROSITE	PS00856. GUANYLATE_KINASE_1. 1 hit. PS50052. GUANYLATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KGUA_DEHSC

Accession

Primary (citable) accession number: Q3ZWD8

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	September 27, 2005
Last modified:	May 1, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program