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Q3ZWB0

- PYRF_DEHMC

UniProt

Q3ZWB0 - PYRF_DEHMC

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Protein
Orotidine 5'-phosphate decarboxylase
Gene
pyrF, cbdbA14
Organism
Dehalococcoides mccartyi (strain CBDB1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei89 – 891Proton donor By similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
  2. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

BioCyciDSP255470:GJXW-12-MONOMER.
UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Gene namesi
Name:pyrF
Ordered Locus Names:cbdbA14
OrganismiDehalococcoides mccartyi (strain CBDB1)
Taxonomic identifieri255470 [NCBI]
Taxonomic lineageiBacteriaChloroflexiDehalococcoidiaDehalococcoidalesDehalococcoidaceaeDehalococcoides
ProteomesiUP000000433: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 270270Orotidine 5'-phosphate decarboxylaseUniRule annotation
PRO_1000066471Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi255470.cbdb_A14.

Structurei

3D structure databases

ProteinModelPortaliQ3ZWB0.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0284.
KOiK01591.
OMAiREGPWSR.
OrthoDBiEOG6DZF33.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01215. OMPdecase_type2.
InterProiIPR013785. Aldolase_TIM.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR02127. pyrF_sub2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3ZWB0-1 [UniParc]FASTAAdd to Basket

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MKFLEKLKQA GNRNKSLLCV GLDPDPKLMP VGMSALEFNR EIIEATAPFV    50
CGYKINLAFY EALGKQGWEI LSETCEFIPR ELITIADAKR GDIGNTSKAY 100
ARAILDELDC DGVTVSPYLG YDSLEPFIEY QDKGIFILCL TSNQGSTDFQ 150
MLKTEYLGQK RFLYEVVADK ASLWNRYENI GLVVGATQQE ELKKLRLSYP 200
KLPFLIPGIG AQGGDLKATI ENGTNPNGEL AIICASRGIL YARSGSEFAQ 250
GAAEAAEQMR DAINHYRKRF 270
Length:270
Mass (Da):29,988
Last modified:September 27, 2005 - v1
Checksum:i9AE1CFECD7021284
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ965256 Genomic DNA. Translation: CAI82291.1.
RefSeqiWP_011308650.1. NC_007356.1.
YP_307207.1. NC_007356.1.

Genome annotation databases

EnsemblBacteriaiCAI82291; CAI82291; cbdbA14.
GeneIDi3623676.
KEGGideh:cbdb_A14.
PATRICi21610323. VBIDehSp125902_0012.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ965256 Genomic DNA. Translation: CAI82291.1 .
RefSeqi WP_011308650.1. NC_007356.1.
YP_307207.1. NC_007356.1.

3D structure databases

ProteinModelPortali Q3ZWB0.
ModBasei Search...

Protein-protein interaction databases

STRINGi 255470.cbdb_A14.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAI82291 ; CAI82291 ; cbdbA14 .
GeneIDi 3623676.
KEGGi deh:cbdb_A14.
PATRICi 21610323. VBIDehSp125902_0012.

Phylogenomic databases

eggNOGi COG0284.
KOi K01591.
OMAi REGPWSR.
OrthoDBi EOG6DZF33.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .
BioCyci DSP255470:GJXW-12-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01215. OMPdecase_type2.
InterProi IPR013785. Aldolase_TIM.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR02127. pyrF_sub2. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the chlorinated compound-respiring bacterium Dehalococcoides species strain CBDB1."
    Kube M., Beck A., Zinder S.H., Kuhl H., Reinhardt R., Adrian L.
    Nat. Biotechnol. 23:1269-1273(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CBDB1.

Entry informationi

Entry nameiPYRF_DEHMC
AccessioniPrimary (citable) accession number: Q3ZWB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: September 27, 2005
Last modified: September 3, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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