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Protein

Golgin subfamily A member 5

Gene

Golga5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport.2 Publications

GO - Molecular functioni

  • protein binding, bridging Source: RGD
  • protein homodimerization activity Source: UniProtKB
  • Rab GTPase binding Source: RGD

GO - Biological processi

  • Golgi organization Source: UniProtKB
  • Golgi vesicle transport Source: UniProtKB
  • retrograde transport, vesicle recycling within Golgi Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Golgin subfamily A member 5
Alternative name(s):
Golgin-84
Gene namesi
Name:Golga5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1308163. Golga5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 695694CytoplasmicSequence analysisAdd
BLAST
Transmembranei696 – 71621Helical; Anchor for type IV membrane proteinSequence analysisAdd
BLAST
Topological domaini717 – 72812LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

  • COPI-coated vesicle membrane Source: RGD
  • Golgi apparatus Source: UniProtKB
  • Golgi cis cisterna Source: RGD
  • Golgi medial cisterna Source: RGD
  • Golgi membrane Source: RGD
  • Golgi trans cisterna Source: RGD
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 728727Golgin subfamily A member 5PRO_0000190063Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei27 – 271Dimethylated arginine1 Publication
Modified residuei89 – 891Dimethylated arginine1 Publication
Modified residuei116 – 1161PhosphoserineCombined sources

Post-translational modificationi

Highly phosphorylated during mitosis. Phosphorylation is barely detectable during interphase (By similarity).By similarity

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ3ZU82.
PRIDEiQ3ZU82.

PTM databases

iPTMnetiQ3ZU82.
PhosphoSiteiQ3ZU82.

Interactioni

Subunit structurei

Homodimer. Interacts with RAB1A that has been activated by GTP-binding. Interacts with isoform CASP of CUX1.2 Publications

GO - Molecular functioni

  • protein binding, bridging Source: RGD
  • protein homodimerization activity Source: UniProtKB
  • Rab GTPase binding Source: RGD

Protein-protein interaction databases

MINTiMINT-4573523.
STRINGi10116.ENSRNOP00000010385.

Structurei

3D structure databases

ProteinModelPortaliQ3ZU82.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili216 – 628413Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4677. Eukaryota.
ENOG410XR4F. LUCA.
HOGENOMiHOG000273871.
HOVERGENiHBG051755.
InParanoidiQ3ZU82.
PhylomeDBiQ3ZU82.

Family and domain databases

InterProiIPR019177. Golgin_subfamily_A_member_5.
[Graphical view]
PfamiPF09787. Golgin_A5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3ZU82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWFADLAGR AEDLLNRVDQ GAATALRKES TSNTFYSKNT DYPELHQQNT
60 70 80 90 100
DSTYHTGQKA NYISSAADNI RHQKATIIAG TANVKVGSRT GGDASHPTEH
110 120 130 140 150
ASVPRPSSHF VRRKKSEPDD ELLFDFLNSS QKEPTGRVEI KKEKGKAPVL
160 170 180 190 200
PSSQSSAVSS VTTSVTTIKA TEENSGSQSP EVSSSDSMPE GHKKSTEEST
210 220 230 240 250
VSNAISVEHS SVPSDGSMSH ELSNLRLENQ LLRNEVQSLN QEMASLLQRS
260 270 280 290 300
KETQEELNEA RVRVEKWNVD NSKSDRITRE LRAQVDDLTE AVAAKDSQLA
310 320 330 340 350
VLKVRLQEAD QVLSSRTEAL EALQSEKSRI MQDHNEGSSL QNQALQTLQE
360 370 380 390 400
RHEADATLKR EQESYKQMQS EFATRLNKME VERQNLAEAV TLAERKYSEE
410 420 430 440 450
RKKVDDLQQQ VKLHRSSLES AKQELVDYKQ KATRILQSKE KLINSLKEGS
460 470 480 490 500
SFEGLDSSTA SSMELEELRH ERELQKEEIQ KLMGQIHQLR SELQDMEAQQ
510 520 530 540 550
VSEAESAREQ LQDLQDQIAK QRASKQELET ELDRMKQEFH YVEEDLHRTK
560 570 580 590 600
NTLQSRIKDR EEEIQKLRNQ LTNKTLSNSS QSELESRLHQ LTETLIQKQT
610 620 630 640 650
LLESLSTEKN SLVFQLERLE QQLHSAATGP SSGSSINMSG VDSGEGTRLR
660 670 680 690 700
NVPVLFNDTE TNLAGMYGKV RKAASSIDQF SIRLGIFLRR YPIARVFVII
710 720
YMALLHLWVM IVLLTYSPEM HHDQPYGK
Length:728
Mass (Da):82,334
Last modified:September 27, 2005 - v1
Checksum:i0C30FCB93C8E310A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY144587 mRNA. Translation: AAN17671.1.
RefSeqiNP_001028237.1. NM_001033065.1.
UniGeneiRn.205745.

Genome annotation databases

GeneIDi299258.
KEGGirno:299258.
UCSCiRGD:1308163. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY144587 mRNA. Translation: AAN17671.1.
RefSeqiNP_001028237.1. NM_001033065.1.
UniGeneiRn.205745.

3D structure databases

ProteinModelPortaliQ3ZU82.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4573523.
STRINGi10116.ENSRNOP00000010385.

PTM databases

iPTMnetiQ3ZU82.
PhosphoSiteiQ3ZU82.

Proteomic databases

PaxDbiQ3ZU82.
PRIDEiQ3ZU82.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi299258.
KEGGirno:299258.
UCSCiRGD:1308163. rat.

Organism-specific databases

CTDi9950.
RGDi1308163. Golga5.

Phylogenomic databases

eggNOGiKOG4677. Eukaryota.
ENOG410XR4F. LUCA.
HOGENOMiHOG000273871.
HOVERGENiHBG051755.
InParanoidiQ3ZU82.
PhylomeDBiQ3ZU82.

Miscellaneous databases

NextBioi645104.
PROiQ3ZU82.

Family and domain databases

InterProiIPR019177. Golgin_subfamily_A_member_5.
[Graphical view]
PfamiPF09787. Golgin_A5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Golgin-84 is a rab1 binding partner involved in Golgi structure."
    Satoh A., Wang Y., Malsam J., Beard M.B., Warren G.
    Traffic 4:153-161(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH RAB1A, FUNCTION, SUBCELLULAR LOCATION.
    Tissue: Liver.
  2. Cited for: METHYLATION AT ARG-27 AND ARG-89, IDENTIFICATION BY MASS SPECTROMETRY.
  3. "Golgin tethers define subpopulations of COPI vesicles."
    Malsam J., Satoh A., Pelletier L., Warren G.
    Science 307:1095-1098(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CUX1.
  4. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-116, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGOGA5_RAT
AccessioniPrimary (citable) accession number: Q3ZU82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: September 27, 2005
Last modified: January 20, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.