Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tumor necrosis factor receptor superfamily member 5

Gene

CD40

Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processImmunity

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 5
Alternative name(s):
B-cell surface antigen CD40
CD40L receptor
CD_antigen: CD40
Gene namesi
Name:CD40
Synonyms:TNFRSF5
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Chromosome 22

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 194ExtracellularSequence analysisAdd BLAST174
Transmembranei195 – 215HelicalSequence analysisAdd BLAST21
Topological domaini216 – 280CytoplasmicSequence analysisAdd BLAST65

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000025269521 – 280Tumor necrosis factor receptor superfamily member 5Add BLAST260

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26 ↔ 37PROSITE-ProRule annotation
Disulfide bondi38 ↔ 51PROSITE-ProRule annotation
Disulfide bondi41 ↔ 59PROSITE-ProRule annotation
Disulfide bondi62 ↔ 77PROSITE-ProRule annotation
Disulfide bondi83 ↔ 103PROSITE-ProRule annotation
Disulfide bondi105 ↔ 119PROSITE-ProRule annotation
Disulfide bondi111 ↔ 116PROSITE-ProRule annotation
Disulfide bondi125 ↔ 143PROSITE-ProRule annotation
Glycosylationi180N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ3ZTK5.

Expressioni

Gene expression databases

BgeeiENSECAG00000016998.

Interactioni

Subunit structurei

Monomer and homodimer. Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6. Interacts with TRAF6 and MAP3K8; the interaction is required for ERK activation (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9796.ENSECAP00000014907.

Structurei

3D structure databases

ProteinModelPortaliQ3ZTK5.
SMRiQ3ZTK5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati25 – 60TNFR-Cys 1Add BLAST36
Repeati61 – 103TNFR-Cys 2Add BLAST43
Repeati104 – 144TNFR-Cys 3Add BLAST41
Repeati145 – 187TNFR-Cys 4Add BLAST43

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IY0H. Eukaryota.
ENOG4112DB5. LUCA.
GeneTreeiENSGT00760000119204.
HOGENOMiHOG000136317.
HOVERGENiHBG005117.
InParanoidiQ3ZTK5.
KOiK03160.
OMAiCHPWTSC.
OrthoDBiEOG091G03XW.
TreeFamiTF331157.

Family and domain databases

CDDicd13407. TNFRSF5. 1 hit.
InterProiView protein in InterPro
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020435. TNFR_5.
IPR034021. TNFRSF5_N.
PfamiView protein in Pfam
PF00020. TNFR_c6. 1 hit.
PRINTSiPR01922. TNFACTORR5.
SMARTiView protein in SMART
SM00208. TNFR. 4 hits.
PROSITEiView protein in PROSITE
PS00652. TNFR_NGFR_1. 1 hit.
PS50050. TNFR_NGFR_2. 3 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3ZTK5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRLPLQCLL WGCLLTPVHP EQATACKGNQ YLSGSHCCDL CPPGKKLVND
60 70 80 90 100
CTGITETECS PCGAGEFLDT WNRESRCHQH KYCDPNLGLQ VQGTGTSTTD
110 120 130 140 150
ATCICHEGQH CSSDACESCI LHSPCAPGLG VKQLATGVSD TVCEPCPVGF
160 170 180 190 200
FSKVSSALEK CHPWTSCDTK GLVELQAGTN KTDAVCGFRN RMRALVVIPI
210 220 230 240 250
TMGVLFAVLL LSACIRKVAK EPENKALHRK VGWQDPVETV YPDDFPGPHS
260 270 280
IAPVQETLHG CQPVTQEDGK ESRISVQERQ
Length:280
Mass (Da):30,279
Last modified:September 27, 2005 - v1
Checksum:i1667919F81D60D68
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY514017 mRNA. Translation: AAS82955.1.
RefSeqiNP_001075371.1. NM_001081902.1.
UniGeneiEca.12610.

Genome annotation databases

EnsembliENSECAT00000018286; ENSECAP00000014907; ENSECAG00000016998.
GeneIDi100034049.
KEGGiecb:100034049.

Similar proteinsi

Entry informationi

Entry nameiTNR5_HORSE
AccessioniPrimary (citable) accession number: Q3ZTK5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: September 27, 2005
Last modified: August 30, 2017
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome