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Protein

Tumor necrosis factor receptor superfamily member 5

Gene

CD40

Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 5
Alternative name(s):
B-cell surface antigen CD40
CD40L receptor
CD_antigen: CD40
Gene namesi
Name:CD40
Synonyms:TNFRSF5
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Chromosome 22

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 194ExtracellularSequence analysisAdd BLAST174
Transmembranei195 – 215HelicalSequence analysisAdd BLAST21
Topological domaini216 – 280CytoplasmicSequence analysisAdd BLAST65

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000025269521 – 280Tumor necrosis factor receptor superfamily member 5Add BLAST260

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26 ↔ 37PROSITE-ProRule annotation
Disulfide bondi38 ↔ 51PROSITE-ProRule annotation
Disulfide bondi41 ↔ 59PROSITE-ProRule annotation
Disulfide bondi62 ↔ 77PROSITE-ProRule annotation
Disulfide bondi83 ↔ 103PROSITE-ProRule annotation
Disulfide bondi105 ↔ 119PROSITE-ProRule annotation
Disulfide bondi111 ↔ 116PROSITE-ProRule annotation
Disulfide bondi125 ↔ 143PROSITE-ProRule annotation
Glycosylationi180N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ3ZTK5.

Interactioni

Subunit structurei

Monomer and homodimer. Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6. Interacts with TRAF6 and MAP3K8; the interaction is required for ERK activation (By similarity).By similarity

Protein-protein interaction databases

STRINGi9796.ENSECAP00000014907.

Structurei

3D structure databases

ProteinModelPortaliQ3ZTK5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati25 – 60TNFR-Cys 1Add BLAST36
Repeati61 – 103TNFR-Cys 2Add BLAST43
Repeati104 – 144TNFR-Cys 3Add BLAST41
Repeati145 – 187TNFR-Cys 4Add BLAST43

Sequence similaritiesi

Contains 4 TNFR-Cys repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IY0H. Eukaryota.
ENOG4112DB5. LUCA.
GeneTreeiENSGT00760000119204.
HOGENOMiHOG000136317.
HOVERGENiHBG005117.
InParanoidiQ3ZTK5.
KOiK03160.
OMAiEKCHPWT.
OrthoDBiEOG091G03XW.
TreeFamiTF331157.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020435. TNFR_5.
[Graphical view]
PfamiPF00020. TNFR_c6. 1 hit.
[Graphical view]
PRINTSiPR01922. TNFACTORR5.
SMARTiSM00208. TNFR. 4 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 1 hit.
PS50050. TNFR_NGFR_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3ZTK5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRLPLQCLL WGCLLTPVHP EQATACKGNQ YLSGSHCCDL CPPGKKLVND
60 70 80 90 100
CTGITETECS PCGAGEFLDT WNRESRCHQH KYCDPNLGLQ VQGTGTSTTD
110 120 130 140 150
ATCICHEGQH CSSDACESCI LHSPCAPGLG VKQLATGVSD TVCEPCPVGF
160 170 180 190 200
FSKVSSALEK CHPWTSCDTK GLVELQAGTN KTDAVCGFRN RMRALVVIPI
210 220 230 240 250
TMGVLFAVLL LSACIRKVAK EPENKALHRK VGWQDPVETV YPDDFPGPHS
260 270 280
IAPVQETLHG CQPVTQEDGK ESRISVQERQ
Length:280
Mass (Da):30,279
Last modified:September 27, 2005 - v1
Checksum:i1667919F81D60D68
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY514017 mRNA. Translation: AAS82955.1.
RefSeqiNP_001075371.1. NM_001081902.1.
UniGeneiEca.12610.

Genome annotation databases

EnsembliENSECAT00000018286; ENSECAP00000014907; ENSECAG00000016998.
GeneIDi100034049.
KEGGiecb:100034049.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY514017 mRNA. Translation: AAS82955.1.
RefSeqiNP_001075371.1. NM_001081902.1.
UniGeneiEca.12610.

3D structure databases

ProteinModelPortaliQ3ZTK5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9796.ENSECAP00000014907.

Proteomic databases

PaxDbiQ3ZTK5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSECAT00000018286; ENSECAP00000014907; ENSECAG00000016998.
GeneIDi100034049.
KEGGiecb:100034049.

Organism-specific databases

CTDi958.

Phylogenomic databases

eggNOGiENOG410IY0H. Eukaryota.
ENOG4112DB5. LUCA.
GeneTreeiENSGT00760000119204.
HOGENOMiHOG000136317.
HOVERGENiHBG005117.
InParanoidiQ3ZTK5.
KOiK03160.
OMAiEKCHPWT.
OrthoDBiEOG091G03XW.
TreeFamiTF331157.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020435. TNFR_5.
[Graphical view]
PfamiPF00020. TNFR_c6. 1 hit.
[Graphical view]
PRINTSiPR01922. TNFACTORR5.
SMARTiSM00208. TNFR. 4 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 1 hit.
PS50050. TNFR_NGFR_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTNR5_HORSE
AccessioniPrimary (citable) accession number: Q3ZTK5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: September 27, 2005
Last modified: November 30, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.