Q3ZTK5 (TNR5_HORSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tumor necrosis factor receptor superfamily member 5

Alternative name(s):
B-cell surface antigen CD40
CD40L receptor
CD_antigen=CD40

Gene names

Name:	CD40
Synonyms:	TNFRSF5

Organism

Equus caballus (Horse) [Reference proteome]

Taxonomic identifier

9796 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › Equus

Protein attributes

Sequence length	280 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for TNFSF5/CD40LG By similarity.
Subunit structure	Monomer and homodimer. Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6 By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein.
Sequence similarities	Contains 4 TNFR-Cys repeats.

Ontologies

Keywords
Cellular component	Membrane
Domain	Repeat Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	B cell activation Inferred from electronic annotation. Source: Compara cellular calcium ion homeostasis Inferred from electronic annotation. Source: Compara cellular response to mechanical stimulus Inferred from electronic annotation. Source: Compara defense response to virus Inferred from electronic annotation. Source: Compara immune response-regulating cell surface receptor signaling pathway Inferred from electronic annotation. Source: Compara positive regulation of B cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of Cdc42 GTPase activity Inferred from electronic annotation. Source: Compara positive regulation of I-kappaB kinase/NF-kappaB cascade Inferred from electronic annotation. Source: Compara positive regulation of MAP kinase activity Inferred from electronic annotation. Source: Compara positive regulation of NF-kappaB transcription factor activity Inferred from electronic annotation. Source: Compara positive regulation of Rac GTPase activity Inferred from electronic annotation. Source: Compara positive regulation of endothelial cell apoptotic process Inferred from electronic annotation. Source: Compara positive regulation of interleukin-12 production Inferred from electronic annotation. Source: Compara positive regulation of isotype switching to IgG isotypes Inferred from electronic annotation. Source: Compara positive regulation of protein kinase C signaling cascade Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara positive regulation of tyrosine phosphorylation of Stat1 protein Inferred from electronic annotation. Source: Compara regulation of immunoglobulin secretion Inferred from electronic annotation. Source: Compara
Cellular_component	CD40 receptor complex Inferred from electronic annotation. Source: Compara external side of plasma membrane Inferred from electronic annotation. Source: Compara intracellular membrane-bounded organelle Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 280	260	Tumor necrosis factor receptor superfamily member 5		PRO_0000252695
Regions
	Topological domain	21 – 194	174	Extracellular Potential
	Transmembrane	195 – 215	21	Helical; Potential
	Topological domain	216 – 280	65	Cytoplasmic Potential
	Repeat	25 – 60	36	TNFR-Cys 1
	Repeat	61 – 103	43	TNFR-Cys 2
	Repeat	104 – 144	41	TNFR-Cys 3
	Repeat	145 – 187	43	TNFR-Cys 4
Amino acid modifications
	Modified residue	275	1	Phosphoserine By similarity
	Glycosylation	180	1	N-linked (GlcNAc...) Potential
	Disulfide bond	26 ↔ 37		By similarity
	Disulfide bond	38 ↔ 51		By similarity
	Disulfide bond	41 ↔ 59		By similarity
	Disulfide bond	62 ↔ 77		By similarity
	Disulfide bond	83 ↔ 103		By similarity
	Disulfide bond	105 ↔ 119		By similarity
	Disulfide bond	111 ↔ 116		By similarity
	Disulfide bond	125 ↔ 143		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3ZTK5 [UniParc]. Last modified September 27, 2005. Version 1. Checksum: 1667919F81D60D68	FASTA	280	30,279
	10 20 30 40 50 60 MVRLPLQCLL WGCLLTPVHP EQATACKGNQ YLSGSHCCDL CPPGKKLVND CTGITETECS 70 80 90 100 110 120 PCGAGEFLDT WNRESRCHQH KYCDPNLGLQ VQGTGTSTTD ATCICHEGQH CSSDACESCI 130 140 150 160 170 180 LHSPCAPGLG VKQLATGVSD TVCEPCPVGF FSKVSSALEK CHPWTSCDTK GLVELQAGTN 190 200 210 220 230 240 KTDAVCGFRN RMRALVVIPI TMGVLFAVLL LSACIRKVAK EPENKALHRK VGWQDPVETV 250 260 270 280 YPDDFPGPHS IAPVQETLHG CQPVTQEDGK ESRISVQERQ

References

[1]	"The CD40 gene of the horse." Wagner B., Antczak D.F. Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY514017 mRNA. Translation: AAS82955.1.
RefSeq	NP_001075371.1. NM_001081902.1.
UniGene	Eca.12610.
3D structure databases
HSSP	HSSP built from PDB template 2AW2 based on UniProtKB Q92956.
ProteinModelPortal	Q3ZTK5.
ModBase	Search...
Protein-protein interaction databases
STRING	9796.ENSECAP00000014907.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSECAT00000018286; ENSECAP00000014907; ENSECAG00000016998.
GeneID	100034049.
KEGG	ecb:100034049.
Organism-specific databases
CTD	958.
Phylogenomic databases
eggNOG	NOG28193.
GeneTree	ENSGT00700000104362.
HOGENOM	HOG000136317.
HOVERGEN	HBG005117.
InParanoid	Q3ZTK5.
KO	K03160.
OMA	EKCHPWT.
OrthoDB	EOG49PB0W.
Family and domain databases
InterPro	IPR001368. TNFR/NGFR_Cys_rich_reg. IPR020435. TNFR_5. [Graphical view]
Pfam	PF00020. TNFR_c6. 1 hit. [Graphical view]
PRINTS	PR01922. TNFACTORR5.
SMART	SM00208. TNFR. 4 hits. [Graphical view]
PROSITE	PS00652. TNFR_NGFR_1. 1 hit. PS50050. TNFR_NGFR_2. 3 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TNR5_HORSE

Accession

Primary (citable) accession number: Q3ZTK5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 17, 2006
Last sequence update:	September 27, 2005
Last modified:	April 3, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program