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Protein

Sorting nexin-25

Gene

Snx25

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in several stages of intracellular trafficking.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-25
Gene namesi
Name:Snx25
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2142610. Snx25.

Subcellular locationi

GO - Cellular componenti

  • endosome Source: UniProtKB
  • endosome membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 840840Sorting nexin-25PRO_0000352799Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei665 – 6651PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ3ZT31.
MaxQBiQ3ZT31.
PaxDbiQ3ZT31.
PRIDEiQ3ZT31.

PTM databases

iPTMnetiQ3ZT31.
PhosphoSiteiQ3ZT31.

Expressioni

Gene expression databases

BgeeiQ3ZT31.
ExpressionAtlasiQ3ZT31. baseline and differential.
GenevisibleiQ3ZT31. MM.

Interactioni

GO - Molecular functioni

  • type I transforming growth factor beta receptor binding Source: UniProtKB

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035785.

Structurei

3D structure databases

ProteinModelPortaliQ3ZT31.
SMRiQ3ZT31. Positions 506-624.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 164164PXAPROSITE-ProRule annotationAdd
BLAST
Domaini287 – 401115RGSPROSITE-ProRule annotationAdd
BLAST
Domaini508 – 628121PXPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili446 – 49449Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the sorting nexin family.Curated
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation
Contains 1 PXA domain.PROSITE-ProRule annotation
Contains 1 RGS domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2101. Eukaryota.
ENOG410XQM8. LUCA.
GeneTreeiENSGT00800000124081.
HOGENOMiHOG000047059.
HOVERGENiHBG066560.
InParanoidiQ3ZT31.
KOiK17887.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
IPR003114. Phox_assoc.
IPR016137. RGS.
IPR013937. Sorting_nexin_C.
[Graphical view]
PfamiPF08628. Nexin_C. 1 hit.
PF00787. PX. 1 hit.
PF02194. PXA. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
SM00313. PXA. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
PS51207. PXA. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3ZT31-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRVLRDVFD YSYRDYILSW YGNLSRDDGQ LYHLLLDDFW EIVKQIRQRL
60 70 80 90 100
SHVDVVKVVC NDIVKALLTH FCDLKAATAR HEEQPRPFVL HACLKDSHDE
110 120 130 140 150
VRFLQTCSQV LVLCLLPSKD IQSLSLRTML AEILTTKVLK PVVELLSNPD
160 170 180 190 200
YINQMLLRQL EYREQMSEHH KRAYTYAPSY EDFIKLINSN SDVDFLKQLR
210 220 230 240 250
YQIVVEIIQA TTISSFPQLK RHKGKESAAM KTDLLRARNM KRYINQLTVA
260 270 280 290 300
KKQCEKRIRI LGGPAYDQQE DGASDEGEGP QSQKILQFED IMTNPFYRER
310 320 330 340 350
FGTYMERIDK RALVGFWESA EHLKNANKSE IPQLVSEMYQ NFFVESKEIS
360 370 380 390 400
VEKSLYKEIQ QCLVGNRGIE VFSKIQADVS EVLRERYYPS FLVSDLYEKL
410 420 430 440 450
MREEEEEEPD AQLASEKDEL GSGGEAGEEA VEGTSGVSDP ASFAVIKLRE
460 470 480 490 500
LNEKLEYKRQ ALSSIQNAPK PDKKIISKLK DEILLIEKEC TALQLHMART
510 520 530 540 550
DWWCENLGLW RASITSAEVT EENGEQMPCY FVRVNLQEVG GVETKNWTVP
560 570 580 590 600
RRLSEFQNLH RKLSECVPSL KKVQLPSLSK LPFKSIDHKF LGKSRNQLNA
610 620 630 640 650
FLQNLLSDER LFQSEALYAF LSPSPDYLKV IDVQGKKTSF SLSSFLEKLP
660 670 680 690 700
RDFFSHQEEE IEEDSDLSDY GDDVDGKKDS LAEPCFMLIG EIFELRGMFK
710 720 730 740 750
WVRRTLIALV QVTFGRTINK QIRDTVSWIS SEQMLVYYIS AFRDAFWPNG
760 770 780 790 800
KLAPPTRIRS VAQSQETKQR AQQKLLENIP DTLQSLVGQQ NARHGIIKIF
810 820 830 840
KALQETKANK HLLYVLMELL LTELCPELRA HLDQFKAGQV
Length:840
Mass (Da):97,146
Last modified:September 21, 2011 - v3
Checksum:i35B02C44AE7C1B50
GO

Sequence cautioni

The sequence AAT98626.1 differs from that shown.Intron retention.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti25 – 251S → T in CJ047380 (PubMed:16141072).Curated
Sequence conflicti27 – 271D → H in CJ047380 (PubMed:16141072).Curated
Sequence conflicti45 – 451Q → H in CJ047380 (PubMed:16141072).Curated
Sequence conflicti48 – 481Q → H in CJ047380 (PubMed:16141072).Curated
Sequence conflicti57 – 571K → Q in CJ047380 (PubMed:16141072).Curated
Sequence conflicti61 – 611N → Y in CJ047380 (PubMed:16141072).Curated
Sequence conflicti70 – 712HF → TS in CJ047380 (PubMed:16141072).Curated
Sequence conflicti73 – 731D → E in CJ047380 (PubMed:16141072).Curated
Sequence conflicti322 – 3221H → D in AAT98626 (Ref. 1) Curated
Sequence conflicti385 – 3851E → D in AAT98626 (Ref. 1) Curated
Sequence conflicti427 – 4271G → S in AAT98626 (Ref. 1) Curated
Sequence conflicti646 – 6461L → P in AAT98626 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY601646 mRNA. Translation: AAT98626.1. Sequence problems.
AC114558 Genomic DNA. No translation available.
CJ047380 mRNA. No translation available.
BC057063 mRNA. Translation: AAH57063.1.
CCDSiCCDS22287.2.
RefSeqiNP_997096.2. NM_207213.2.
XP_006509305.2. XM_006509242.2.
XP_006509306.1. XM_006509243.2.
UniGeneiMm.267258.

Genome annotation databases

EnsembliENSMUST00000041582; ENSMUSP00000035785; ENSMUSG00000038291.
ENSMUST00000170416; ENSMUSP00000127640; ENSMUSG00000038291.
GeneIDi102141.
KEGGimmu:102141.
UCSCiuc009lpu.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY601646 mRNA. Translation: AAT98626.1. Sequence problems.
AC114558 Genomic DNA. No translation available.
CJ047380 mRNA. No translation available.
BC057063 mRNA. Translation: AAH57063.1.
CCDSiCCDS22287.2.
RefSeqiNP_997096.2. NM_207213.2.
XP_006509305.2. XM_006509242.2.
XP_006509306.1. XM_006509243.2.
UniGeneiMm.267258.

3D structure databases

ProteinModelPortaliQ3ZT31.
SMRiQ3ZT31. Positions 506-624.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035785.

PTM databases

iPTMnetiQ3ZT31.
PhosphoSiteiQ3ZT31.

Proteomic databases

EPDiQ3ZT31.
MaxQBiQ3ZT31.
PaxDbiQ3ZT31.
PRIDEiQ3ZT31.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041582; ENSMUSP00000035785; ENSMUSG00000038291.
ENSMUST00000170416; ENSMUSP00000127640; ENSMUSG00000038291.
GeneIDi102141.
KEGGimmu:102141.
UCSCiuc009lpu.2. mouse.

Organism-specific databases

CTDi83891.
MGIiMGI:2142610. Snx25.

Phylogenomic databases

eggNOGiKOG2101. Eukaryota.
ENOG410XQM8. LUCA.
GeneTreeiENSGT00800000124081.
HOGENOMiHOG000047059.
HOVERGENiHBG066560.
InParanoidiQ3ZT31.
KOiK17887.

Miscellaneous databases

PROiQ3ZT31.
SOURCEiSearch...

Gene expression databases

BgeeiQ3ZT31.
ExpressionAtlasiQ3ZT31. baseline and differential.
GenevisibleiQ3ZT31. MM.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
IPR003114. Phox_assoc.
IPR016137. RGS.
IPR013937. Sorting_nexin_C.
[Graphical view]
PfamiPF08628. Nexin_C. 1 hit.
PF00787. PX. 1 hit.
PF02194. PXA. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
SM00313. PXA. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
PS51207. PXA. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Hao X., Chang Z., Zhu S.
    Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJ.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-74.
    Tissue: Testis.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 64-840.
    Strain: C57BL/6J.
    Tissue: Brain.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Lung and Testis.

Entry informationi

Entry nameiSNX25_MOUSE
AccessioniPrimary (citable) accession number: Q3ZT31
Secondary accession number(s): E9QMG5, Q6PGF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 4, 2008
Last sequence update: September 21, 2011
Last modified: June 8, 2016
This is version 73 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.