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Q3ZLH8

- Q3ZLH8_9HIV1

UniProt

Q3ZLH8 - Q3ZLH8_9HIV1

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Protein

Envelope glycoprotein gp160

Gene

env

Organism
Human immunodeficiency virus 1
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface.UniRule annotationSAAS annotation
The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves.SAAS annotation

GO - Molecular functioni

  1. structural molecule activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. evasion or tolerance by virus of host immune response Source: UniProtKB-KW
  3. membrane fusion involved in viral entry into host cell Source: UniProtKB-KW
  4. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

ApoptosisSAAS annotation, Fusion of virus membrane with host membraneSAAS annotation, Host-virus interaction, Viral attachment to host cellUniRule annotationSAAS annotation, Viral immunoevasionUniRule annotation, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein gp160UniRule annotation
Gene namesi
Name:envImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

Virion membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation. Host cell membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation. Host endosome membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation

GO - Cellular componenti

  1. host cell endosome membrane Source: UniProtKB-SubCell
  2. host cell plasma membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
  4. viral envelope Source: UniProtKB-KW
  5. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cell membraneSAAS annotation, Host endosomeSAAS annotation, Host membrane, Membrane, Viral envelope proteinUniRule annotationSAAS annotation, Virion

Pathology & Biotechi

Keywords - Diseasei

AIDSUniRule annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi87 – 871N-linked (GlcNAc...)
Glycosylationi297 – 2971N-linked (GlcNAc...)Imported
Glycosylationi404 – 4041N-linked (GlcNAc...)Imported

Keywords - PTMi

Cleavage on pair of basic residuesUniRule annotation, Disulfide bondSAAS annotation

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4I3RX-ray3.00G248-475[»]
4I3SX-ray2.85G248-475[»]
4LSSX-ray2.59G43-486[»]
ProteinModelPortaliQ3ZLH8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Family and domain databases

Gene3Di2.170.40.20. 2 hits.
InterProiIPR000777. HIV1_GP160.
IPR000328. Retroviral_envelope_protein.
[Graphical view]
PfamiPF00516. GP120. 1 hit.
PF00517. GP41. 1 hit.
[Graphical view]
SUPFAMiSSF56502. SSF56502. 2 hits.

Sequencei

Sequence statusi: Complete.

Q3ZLH8 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRVMGIQRNC QHLLRWGTMI LGMIIICSTA EDLWVTVYYG VPVWKNAETT
60 70 80 90 100
LFCASDAKAY KTEVHNVWAT HACVPTDPNP QEIHLENVTE EFNVWKNNMV
110 120 130 140 150
EQMHTDIISL WDQSLKPCVK LTPLCVTLNC INANVTNSSM TNSSMMEGEI
160 170 180 190 200
KNCSYNMTTE LRDKKRKVFS LFYKLDVVPM NENNSEYRLI NCNTSAITQA
210 220 230 240 250
CPKVTFEPIP IHYCAPAGFA ILKCKDEEFN GTGLCKNVST VQCTHGIKPV
260 270 280 290 300
VSTQLLLNGS LAEKEIRIKS ENISDNAKTI IVQLTKPVLI NCARPSNNTR
310 320 330 340 350
KSVHIGPGQA FYATGAITGD IRQAYCVVNR TQWNDTLGQV AIQLRKHWNT
360 370 380 390 400
TIIFNEPSGG DLEITTHSFN CGGEFFYCNT SDLFNSTWNI EGTASINGTE
410 420 430 440 450
SNDNITLPCR IKQIINMWQR VGQAMYAPPI QGVIRCQSNI TGILLTRDGG
460 470 480 490 500
NTGNNSRTNE TFRPGGGDMR DNWRSELYKY KVVKIEPLGV APTKAKRRVV
510 520 530 540 550
EREKRAVGLG AVFIGFLGAA GSTMGAASIT LTVQARQLLS GIVQQQSNLL
560 570 580 590 600
RAIEAQQHLL KLTVWGIKQL QARVLAVERY LKDQQLLGIW GCSGKLICTT
610 620 630 640 650
NVPWNSSWSN KSYNEIWENM TWLQWDKEIN NYTELIYSLI EESQNQQEKN
660 670 680 690 700
EQDLLALDKW ASLWNWFDIS NWLWYIKIFI MIVGGLIGLR IVVAVLSVIN
710 720 730 740 750
RVRQGYSPLS FQTHTPNPRG LDRPERIEEE GGEQDRTRST RLVSGFLALA
760 770 780 790 800
WDDLRSLSLF LYHRLRDFIL IAARTVELLG HSSLKGLRLG WEGLKYLWNL
810 820 830 840 850
LLYWGRELKI SAINLLNTIA IAVAGWTDRV IEIGQGIGRA ILHIPRRIRQ

GFERALL
Length:857
Mass (Da):96,871
Last modified:September 27, 2005 - v1
Checksum:i547947C659E7A0F6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY736810 Genomic DNA. Translation: AAW72235.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY736810 Genomic DNA. Translation: AAW72235.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4I3R X-ray 3.00 G 248-475 [» ]
4I3S X-ray 2.85 G 248-475 [» ]
4LSS X-ray 2.59 G 43-486 [» ]
ProteinModelPortali Q3ZLH8.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.170.40.20. 2 hits.
InterProi IPR000777. HIV1_GP160.
IPR000328. Retroviral_envelope_protein.
[Graphical view ]
Pfami PF00516. GP120. 1 hit.
PF00517. GP41. 1 hit.
[Graphical view ]
SUPFAMi SSF56502. SSF56502. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "Biological and genetic characterization of a panel of sixty human immunodeficiency virus type 1 (HIV-1) isolates, representing clades A, B, C, D, CRF01_AE, and CRF02_AG, for the development and assessment of candidate vaccines."
    Brown B.K., Darden J.M., Tovanabutra S., Oblander T., Frost J., Sanders-Buell E., De Souza M.S., Birx D.L., McCutchan F.E., Polonis V.R.
    Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 00KE_KER2018Imported.
  2. Cited for: X-RAY CRYSTALLOGRAPHY (2.59 ANGSTROMS) OF 43-486, GLYCOSYLATION AT ASN-87.
  3. "Outer domain of HIV-1 gp120: antigenic optimization, structural malleability, and crystal structure with antibody VRC-PG04."
    Joyce M.G., Kanekiyo M., Xu L., Biertumpfel C., Boyington J.C., Moquin S., Shi W., Wu X., Yang Y., Yang Z.Y., Zhang B., Zheng A., Zhou T., Zhu J., Mascola J.R., Kwong P.D., Nabel G.J.
    J. Virol. 87:2294-2306(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.85 ANGSTROMS) OF 248-475, GLYCOSYLATION AT ASN-297 AND ASN-404.

Entry informationi

Entry nameiQ3ZLH8_9HIV1
AccessioniPrimary (citable) accession number: Q3ZLH8
Entry historyi
Integrated into UniProtKB/TrEMBL: September 27, 2005
Last sequence update: September 27, 2005
Last modified: October 29, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3