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Q3ZLH8

- Q3ZLH8_9HIV1

UniProt

Q3ZLH8 - Q3ZLH8_9HIV1

Protein

Envelope glycoprotein gp160

Gene

env

Organism
Human immunodeficiency virus 1
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (27 Sep 2005)
      Previous versions | rss
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    Functioni

    The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface.UniRule annotationSAAS annotation
    The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves.SAAS annotation

    GO - Molecular functioni

    1. structural molecule activity Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. evasion or tolerance by virus of host immune response Source: UniProtKB-KW
    3. membrane fusion involved in viral entry into host cell Source: UniProtKB-KW
    4. virion attachment to host cell Source: UniProtKB-KW

    Keywords - Biological processi

    ApoptosisSAAS annotation, Fusion of virus membrane with host membraneSAAS annotation, Host-virus interaction, Viral attachment to host cellUniRule annotationSAAS annotation, Viral immunoevasionUniRule annotation, Viral penetration into host cytoplasm, Virus entry into host cell

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Envelope glycoprotein gp160UniRule annotation
    Gene namesi
    Name:envImported
    OrganismiHuman immunodeficiency virus 1Imported
    Taxonomic identifieri11676 [NCBI]
    Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
    Virus hostiHomo sapiens (Human) [TaxID: 9606]

    Subcellular locationi

    Virion membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation. Host cell membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation. Host endosome membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation

    GO - Cellular componenti

    1. host cell endosome membrane Source: UniProtKB-SubCell
    2. host cell plasma membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW
    4. viral envelope Source: UniProtKB-KW
    5. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cell membraneSAAS annotation, Host endosomeSAAS annotation, Host membrane, Membrane, Viral envelope proteinUniRule annotationSAAS annotationImported, Virion

    Pathology & Biotechi

    Keywords - Diseasei

    AIDSUniRule annotation

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi87 – 871N-linked (GlcNAc...)
    Glycosylationi297 – 2971N-linked (GlcNAc...)Imported
    Glycosylationi404 – 4041N-linked (GlcNAc...)Imported

    Keywords - PTMi

    Cleavage on pair of basic residuesUniRule annotation, Disulfide bondSAAS annotation

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4I3RX-ray3.00G248-475[»]
    4I3SX-ray2.85G248-475[»]
    4LSSX-ray2.59G43-486[»]
    ProteinModelPortaliQ3ZLH8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Family and domain databases

    Gene3Di2.170.40.20. 2 hits.
    InterProiIPR000777. HIV1_GP160.
    IPR000328. Retroviral_envelope_protein.
    [Graphical view]
    PfamiPF00516. GP120. 1 hit.
    PF00517. GP41. 1 hit.
    [Graphical view]
    SUPFAMiSSF56502. SSF56502. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Q3ZLH8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRVMGIQRNC QHLLRWGTMI LGMIIICSTA EDLWVTVYYG VPVWKNAETT    50
    LFCASDAKAY KTEVHNVWAT HACVPTDPNP QEIHLENVTE EFNVWKNNMV 100
    EQMHTDIISL WDQSLKPCVK LTPLCVTLNC INANVTNSSM TNSSMMEGEI 150
    KNCSYNMTTE LRDKKRKVFS LFYKLDVVPM NENNSEYRLI NCNTSAITQA 200
    CPKVTFEPIP IHYCAPAGFA ILKCKDEEFN GTGLCKNVST VQCTHGIKPV 250
    VSTQLLLNGS LAEKEIRIKS ENISDNAKTI IVQLTKPVLI NCARPSNNTR 300
    KSVHIGPGQA FYATGAITGD IRQAYCVVNR TQWNDTLGQV AIQLRKHWNT 350
    TIIFNEPSGG DLEITTHSFN CGGEFFYCNT SDLFNSTWNI EGTASINGTE 400
    SNDNITLPCR IKQIINMWQR VGQAMYAPPI QGVIRCQSNI TGILLTRDGG 450
    NTGNNSRTNE TFRPGGGDMR DNWRSELYKY KVVKIEPLGV APTKAKRRVV 500
    EREKRAVGLG AVFIGFLGAA GSTMGAASIT LTVQARQLLS GIVQQQSNLL 550
    RAIEAQQHLL KLTVWGIKQL QARVLAVERY LKDQQLLGIW GCSGKLICTT 600
    NVPWNSSWSN KSYNEIWENM TWLQWDKEIN NYTELIYSLI EESQNQQEKN 650
    EQDLLALDKW ASLWNWFDIS NWLWYIKIFI MIVGGLIGLR IVVAVLSVIN 700
    RVRQGYSPLS FQTHTPNPRG LDRPERIEEE GGEQDRTRST RLVSGFLALA 750
    WDDLRSLSLF LYHRLRDFIL IAARTVELLG HSSLKGLRLG WEGLKYLWNL 800
    LLYWGRELKI SAINLLNTIA IAVAGWTDRV IEIGQGIGRA ILHIPRRIRQ 850
    GFERALL 857
    Length:857
    Mass (Da):96,871
    Last modified:September 27, 2005 - v1
    Checksum:i547947C659E7A0F6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY736810 Genomic DNA. Translation: AAW72235.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY736810 Genomic DNA. Translation: AAW72235.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4I3R X-ray 3.00 G 248-475 [» ]
    4I3S X-ray 2.85 G 248-475 [» ]
    4LSS X-ray 2.59 G 43-486 [» ]
    ProteinModelPortali Q3ZLH8.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.170.40.20. 2 hits.
    InterProi IPR000777. HIV1_GP160.
    IPR000328. Retroviral_envelope_protein.
    [Graphical view ]
    Pfami PF00516. GP120. 1 hit.
    PF00517. GP41. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56502. SSF56502. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Biological and genetic characterization of a panel of sixty human immunodeficiency virus type 1 (HIV-1) isolates, representing clades A, B, C, D, CRF01_AE, and CRF02_AG, for the development and assessment of candidate vaccines."
      Brown B.K., Darden J.M., Tovanabutra S., Oblander T., Frost J., Sanders-Buell E., De Souza M.S., Birx D.L., McCutchan F.E., Polonis V.R.
      Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 00KE_KER2018Imported.
    2. Cited for: X-RAY CRYSTALLOGRAPHY (2.59 ANGSTROMS) OF 43-486, GLYCOSYLATION AT ASN-87.
    3. "Outer domain of HIV-1 gp120: antigenic optimization, structural malleability, and crystal structure with antibody VRC-PG04."
      Joyce M.G., Kanekiyo M., Xu L., Biertumpfel C., Boyington J.C., Moquin S., Shi W., Wu X., Yang Y., Yang Z.Y., Zhang B., Zheng A., Zhou T., Zhu J., Mascola J.R., Kwong P.D., Nabel G.J.
      J. Virol. 87:2294-2306(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.85 ANGSTROMS) OF 248-475, GLYCOSYLATION AT ASN-297 AND ASN-404.

    Entry informationi

    Entry nameiQ3ZLH8_9HIV1
    AccessioniPrimary (citable) accession number: Q3ZLH8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 27, 2005
    Last sequence update: September 27, 2005
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3