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Q3ZLH8 (Q3ZLH8_9HIV1) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Envelope glycoprotein gp160 RuleBase RU004292
Gene names
Name:env EMBL AAW72235.1
OrganismHuman immunodeficiency virus 1 EMBL AAW72235.1
Taxonomic identifier11676 [NCBI]
Taxonomic lineageVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length857 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface By similarity. RuleBase RU004292 SAAS SAAS000328

The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves By similarity. SAAS SAAS000328

Subcellular location

Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein By similarity SAAS SAAS000328.

Ontologies

Keywords
   Biological processApoptosis SAAS SAAS000328
Fusion of virus membrane with host membrane SAAS SAAS000328
Host-virus interaction
Viral attachment to host cell RuleBase RU004292 SAAS SAAS000328
Viral immunoevasion RuleBase RU004292
Viral penetration into host cytoplasm
Virus entry into host cell
   Cellular componentHost cell membrane SAAS SAAS000328
Host endosome SAAS SAAS000328
Host membrane
Membrane
Viral envelope protein RuleBase RU003294 SAAS SAAS000328 EMBL AAW72235.1
Virion
   DiseaseAIDS RuleBase RU003294
   DomainTransmembrane
Transmembrane helix SAAS SAAS000328
   PTMCleavage on pair of basic residues RuleBase RU004292
Disulfide bond SAAS SAAS000328
   Technical term3D-structure PDB 4LSS PDB 4I3R PDB 4I3S
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

evasion or tolerance by virus of host immune response

Inferred from electronic annotation. Source: UniProtKB-KW

membrane fusion involved in viral entry into host cell

Inferred from electronic annotation. Source: UniProtKB-KW

virion attachment to host cell

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componenthost cell endosome membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

host cell plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

viral envelope

Inferred from electronic annotation. Source: UniProtKB-KW

virion membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionstructural molecule activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Amino acid modifications

Glycosylation871N-linked (GlcNAc...)
Glycosylation2971N-linked (GlcNAc...) PDB 4I3R
Glycosylation4041N-linked (GlcNAc...) PDB 4I3R

Sequences

Sequence LengthMass (Da)Tools
Q3ZLH8 [UniParc].

Last modified September 27, 2005. Version 1.
Checksum: 547947C659E7A0F6

FASTA85796,871
        10         20         30         40         50         60 
MRVMGIQRNC QHLLRWGTMI LGMIIICSTA EDLWVTVYYG VPVWKNAETT LFCASDAKAY 

        70         80         90        100        110        120 
KTEVHNVWAT HACVPTDPNP QEIHLENVTE EFNVWKNNMV EQMHTDIISL WDQSLKPCVK 

       130        140        150        160        170        180 
LTPLCVTLNC INANVTNSSM TNSSMMEGEI KNCSYNMTTE LRDKKRKVFS LFYKLDVVPM 

       190        200        210        220        230        240 
NENNSEYRLI NCNTSAITQA CPKVTFEPIP IHYCAPAGFA ILKCKDEEFN GTGLCKNVST 

       250        260        270        280        290        300 
VQCTHGIKPV VSTQLLLNGS LAEKEIRIKS ENISDNAKTI IVQLTKPVLI NCARPSNNTR 

       310        320        330        340        350        360 
KSVHIGPGQA FYATGAITGD IRQAYCVVNR TQWNDTLGQV AIQLRKHWNT TIIFNEPSGG 

       370        380        390        400        410        420 
DLEITTHSFN CGGEFFYCNT SDLFNSTWNI EGTASINGTE SNDNITLPCR IKQIINMWQR 

       430        440        450        460        470        480 
VGQAMYAPPI QGVIRCQSNI TGILLTRDGG NTGNNSRTNE TFRPGGGDMR DNWRSELYKY 

       490        500        510        520        530        540 
KVVKIEPLGV APTKAKRRVV EREKRAVGLG AVFIGFLGAA GSTMGAASIT LTVQARQLLS 

       550        560        570        580        590        600 
GIVQQQSNLL RAIEAQQHLL KLTVWGIKQL QARVLAVERY LKDQQLLGIW GCSGKLICTT 

       610        620        630        640        650        660 
NVPWNSSWSN KSYNEIWENM TWLQWDKEIN NYTELIYSLI EESQNQQEKN EQDLLALDKW 

       670        680        690        700        710        720 
ASLWNWFDIS NWLWYIKIFI MIVGGLIGLR IVVAVLSVIN RVRQGYSPLS FQTHTPNPRG 

       730        740        750        760        770        780 
LDRPERIEEE GGEQDRTRST RLVSGFLALA WDDLRSLSLF LYHRLRDFIL IAARTVELLG 

       790        800        810        820        830        840 
HSSLKGLRLG WEGLKYLWNL LLYWGRELKI SAINLLNTIA IAVAGWTDRV IEIGQGIGRA 

       850 
ILHIPRRIRQ GFERALL 

« Hide

References

[1]"Biological and genetic characterization of a panel of sixty human immunodeficiency virus type 1 (HIV-1) isolates, representing clades A, B, C, D, CRF01_AE, and CRF02_AG, for the development and assessment of candidate vaccines."
Brown B.K., Darden J.M., Tovanabutra S., Oblander T., Frost J., Sanders-Buell E., De Souza M.S., Birx D.L., McCutchan F.E., Polonis V.R.
Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 00KE_KER2018 EMBL AAW72235.1.
[2]"Multidonor analysis reveals structural elements, genetic determinants, and maturation pathway for HIV-1 neutralization by VRC01-class antibodies."
NISC Comparative Sequencing Program
Zhou T., Zhu J., Wu X., Moquin S., Zhang B., Acharya P., Georgiev I.S., Altae-Tran H.R., Chuang G.Y., Joyce M.G., Do Kwon Y., Longo N.S., Louder M.K., Luongo T., McKee K., Schramm C.A., Skinner J., Yang Y. expand/collapse author list , Yang Z., Zhang Z., Zheng A., Bonsignori M., Haynes B.F., Scheid J.F., Nussenzweig M.C., Simek M., Burton D.R., Koff W.C., Mullikin J.C., Connors M., Shapiro L., Nabel G.J., Mascola J.R., Kwong P.D.
Immunity 39:245-258(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.59 ANGSTROMS) OF 43-486, GLYCOSYLATION AT ASN-87.
[3]"Outer domain of HIV-1 gp120: antigenic optimization, structural malleability, and crystal structure with antibody VRC-PG04."
Joyce M.G., Kanekiyo M., Xu L., Biertumpfel C., Boyington J.C., Moquin S., Shi W., Wu X., Yang Y., Yang Z.Y., Zhang B., Zheng A., Zhou T., Zhu J., Mascola J.R., Kwong P.D., Nabel G.J.
J. Virol. 87:2294-2306(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.85 ANGSTROMS) OF 248-475, GLYCOSYLATION AT ASN-297 AND ASN-404.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY736810 Genomic DNA. Translation: AAW72235.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4I3RX-ray3.00G248-475[»]
4I3SX-ray2.85G248-475[»]
4LSSX-ray2.59G43-486[»]
ProteinModelPortalQ3ZLH8.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.170.40.20. 2 hits.
InterProIPR000777. HIV1_GP160.
IPR000328. Retroviral_envelope_protein.
[Graphical view]
PfamPF00516. GP120. 1 hit.
PF00517. GP41. 1 hit.
[Graphical view]
SUPFAMSSF56502. SSF56502. 2 hits.
ProtoNetSearch...

Entry information

Entry nameQ3ZLH8_9HIV1
AccessionPrimary (citable) accession number: Q3ZLH8
Entry history
Integrated into UniProtKB/TrEMBL: September 27, 2005
Last sequence update: September 27, 2005
Last modified: February 19, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)