Reviewed, UniProtKB/Swiss-Prot Q3ZKN1 (CATK_CANFA)

Names and origin

Protein names

Recommended name:
    Cathepsin K
    EC=3.4.22.38

Gene names

Name:

CTSK

Organism

Canis familiaris (Dog)

Taxonomic identifier

9615 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis

Protein attributes

Sequence length	330 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation By similarity.
Catalytic activity	Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg.
Subcellular location	Lysosome By similarity.
Sequence similarities	Belongs to the peptidase C1 family.

Ontologies

Keywords
Cellular component	Lysosome
Domain	Signal
Molecular function	Hydrolase Protease Thiol protease
PTM	Disulfide bond Glycoprotein Zymogen
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Cellular component	lysosome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	cysteine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 16	16	Potential
	Propeptide	17 – 115	99	Activation peptide By similarity		PRO_0000270518
	Chain	116 – 330	215	Cathepsin K		PRO_0000270519
Sites
	Active site	140	1	By similarity
	Active site	277	1	By similarity
	Active site	297	1	By similarity
Amino acid modifications
	Glycosylation	104	1	N-linked (GlcNAc...) Potential
	Disulfide bond	137 ↔ 178		By similarity
	Disulfide bond	171 ↔ 211		By similarity
	Disulfide bond	270 ↔ 319		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3ZKN1-1 [UniParc]. Last modified September 27, 2005. Version 1. Checksum: 5276C7222A295678	FASTA	330	37,061
	10 20 30 40 50 60 MWGLEVLLLL PMASFALYPE EILDTQWDLW KKTYRKQYNS KVDELSRRLI WEKNLKHISI 70 80 90 100 110 120 HNLEASLGVH TYELAMNHLG DMTSEEVVQK MTGLKVPPSH SRSNDTLYIP DWESRAPDSV 130 140 150 160 170 180 DYRKKGYVTP VKNQGQCGSC WAFSSVGALE GQLKKKTGKL LNLSPQNLVD CVSENDGCGG 190 200 210 220 230 240 GYMTNAFQYV QKNRGIDSED AYPYVGQDES CMYNPTGKAA KCRGYREIPE GNEKALKRAV 250 260 270 280 290 300 ARVGPISVAI DASLTSFQFY SKGVYYDENC NSDNLNHAVL AVGYGIQKGN KHWIIKNSWG 310 320 330 ENWGNKGYIL MARNKNNACG IANLASFPKM

References

[1]	"Cloning and sequencing of the canine cathepsin K gene." Muir P., Argyle D.J., Manley P.A., Hao Z. Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY738221 mRNA. Translation: AAW65150.1.
RefSeq	NP_001029168.1.
UniGene	Cfa.588
3D structure databases
SMR	Q3ZKN1. Positions 21-330.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3ZKN1.
Protein family/group databases
MEROPS	C01.036.
Genome annotation databases
Ensembl	ENSCAFT00000019202; ENSCAFP00000017808; ENSCAFG00000012093; Canis familiaris. [Genome view] ENSCAFT00000035610; ENSCAFP00000030888; ENSCAFG00000012093; Canis familiaris. [Genome view] ENSCAFT00000035613; ENSCAFP00000030891; ENSCAFG00000012093; Canis familiaris. [Genome view]
GeneID	608843.
KEGG	cfa:608843.
Phylogenomic databases
HOVERGEN	Q3ZKN1.
Enzyme and pathway databases
BRENDA	3.4.22.38. 463.
Family and domain databases
InterPro	IPR000169. Pept_cys_AS. IPR013128. Peptidase_C1A. IPR000668. Peptidase_C1A_C. IPR015644. Peptidase_C1A_cathepsin-K. IPR013201. Prot_inhib_I29. [Graphical view]
PANTHER	PTHR12411:SF55. CathpsnK_like. 1 hit. PTHR12411. Peptidase_C1A. 1 hit.
Pfam	PF08246. Inhibitor_I29. 1 hit. PF00112. Peptidase_C1. 1 hit. [Graphical view]
PRINTS	PR00705. PAPAIN.
ProDom	PD000158. Peptidase_C1. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00645. Pept_C1. 1 hit. [Graphical view]
PROSITE	PS00640. THIOL_PROTEASE_ASN. 1 hit. PS00139. THIOL_PROTEASE_CYS. 1 hit. PS00639. THIOL_PROTEASE_HIS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CATK_CANFA

Accession

Primary (citable) accession number: Q3ZKN1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	September 27, 2005
Last modified:	September 1, 2009
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)