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Q3ZK56

- VP2_ROT41

UniProt

Q3ZK56 - VP2_ROT41

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Protein
Inner capsid protein VP2
Gene
N/A
Organism
Rotavirus A (isolate Human/Belgium/B4106/2000 G3-P11[14]-I2-R2-C2-M3-A9-N2-T6-E5-H3) (RV-A) (Rotavirus A (isolate B4106))
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Inner capsid protein that self assembles to form an icosahedral capsid with a T=2 symmetry, which consists of 120 copies of VP2, with channels at each of its five-fold vertices. This capsid constitutes the innermost concentric layer of the viral mature particle. It encapsidates the polymerase VP1, the capping enzyme VP3 and the genomic dsRNA, thereby defining the core. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP2 is required for the replicase activity of VP1 polymerase. It probably plays a role in the coordination of packaging and genome replication by controlling the initiation of minus-strand synthesis. Binding to the polymerase VP1 presumably activates the autoinhibited VP1-RNA complex which will start the synthesis of the complementary minus-strand By similarity.

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Inner capsid protein VP2
OrganismiRotavirus A (isolate Human/Belgium/B4106/2000 G3-P11[14]-I2-R2-C2-M3-A9-N2-T6-E5-H3) (RV-A) (Rotavirus A (isolate B4106))
Taxonomic identifieri578843 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirusRotavirus A
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000008655: Genome

Subcellular locationi

Virion Reviewed prediction
Note: Inner capsid protein. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.

GO - Cellular componenti

  1. viral inner capsid Source: UniProtKB-KW
  2. viral nucleocapsid Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Inner capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 880880Inner capsid protein VP2
PRO_0000368049Add
BLAST

Proteomic databases

PRIDEiQ3ZK56.

Interactioni

Subunit structurei

Dimer Reviewed prediction. Interacts with VP1; this interaction presumably activates VP1. Interacts with VP3. Interacts with VP6. Interacts with NSP5 By similarity.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 9292Interaction with VP1 and VP3 By similarity
Add
BLAST
Regioni394 – 41421Hydrophobic By similarity
Add
BLAST
Regioni422 – 44221Hydrophobic By similarity
Add
BLAST
Regioni536 – 55722Leucine-zipper 1 Reviewed prediction
Add
BLAST
Regioni665 – 68622Leucine-zipper 2 Reviewed prediction
Add
BLAST

Domaini

The N-terminus is involved in VP1 binding By similarity.

Sequence similaritiesi

Belongs to the rotavirus VP2 family.

Keywords - Domaini

Repeat

Family and domain databases

InterProiIPR007779. Rotavirus_VP2.
[Graphical view]
PfamiPF05087. Rota_VP2. 1 hit.
[Graphical view]
ProDomiPD008866. Rota_VP2. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q3ZK56-1 [UniParc]FASTAAdd to Basket

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MAYRKRGARR EANVNNNDRM QEKDVEKQDQ NSKTQLSDKV LSKKEEIITD    50
NQEEVKIADE VKKSTKEESK QLLEVLKTKE EHQKEIQYEI LQKTIPTFEP 100
KESILKKLED IKPEQAKKQT KLFRIFEPRQ LPIYRANGEK ELRNRWYWKL 150
KKDTLPDGDY DVREYFLNLY DQVLTEMPDY LLLKDMAVEN KNSRDAGKVV 200
DSETASICDA IFQDEETEGA VRRFIAEMRQ RVQADRNVVN YPSILHPIDY 250
AFNEYFLQHQ LVEPLNNDII FNYIPERIRN DVNYILNMDR NLPSTARYIR 300
PNLLQDRLNL HDNFESLWDT ITTSNYILAR SVVPDLKELV STEAQIQKMS 350
QDLQLEALTI QSETQFLTGI NSQAANDCFK TLIAAMLSQR TMSLDFVTTN 400
YMSLISGMWL LTVVPNDMFI RESLVACQLA IVNTIVYPAF GMQRMHYRNG 450
DPQTPFQIAE QQIQNFQVAN WLHFVNNNQF RQVVIDGVLN QVLNDNIRNG 500
HVINQLMEAL MQLSRQQFPT MPVDYKRSIQ RGILLLSNRL GQLVDLTRLL 550
AYNYETLMAC ITMNMQHVQT LTTEKLQLTS VTSLCMLIGN ATVIPSPQTL 600
FHYYNVNVNF HSNYNERIND AVAIITAANR LNLYQKKMKA IVEDFLKRLH 650
IFDVARVPDD QMYRLRDRLR LLPVEVRRLD IFNLILMNMD QIERASDKIA 700
QGVIIAYRDM QLERDEMYGY VNIARNLDGF QQINLEELMR TGDYAQITNM 750
LLNNQPVALV GALPFITDSS VISLIAKLDA TVFAQIVKLR KVDTLKPILY 800
KINSDSNDFY LVANYDWVPT STTKVYKQVP QQFDFRNSMH MLTSNLTFTV 850
YSDLLAFVSA DTVEPINAVA FDNMRIMNEL 880
Length:880
Mass (Da):102,423
Last modified:September 27, 2005 - v1
Checksum:iA1D428BF6D45AA28
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY740740 Genomic RNA. Translation: AAU43798.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY740740 Genomic RNA. Translation: AAU43798.1 .

3D structure databases

ModBasei Search...

Proteomic databases

PRIDEi Q3ZK56.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR007779. Rotavirus_VP2.
[Graphical view ]
Pfami PF05087. Rota_VP2. 1 hit.
[Graphical view ]
ProDomi PD008866. Rota_VP2. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

  1. "Full genomic analysis of human rotavirus strain B4106 and lapine rotavirus strain 30/96 provides evidence for interspecies transmission."
    Matthijnssens J., Rahman M., Martella V., Xuelei Y., De Vos S., De Leener K., Ciarlet M., Buonavoglia C., Van Ranst M.
    J. Virol. 80:3801-3810(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiVP2_ROT41
AccessioniPrimary (citable) accession number: Q3ZK56
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 27, 2005
Last modified: October 16, 2013
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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