Q3ZE13 (RPP30_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribonuclease P protein subunit drpp30
EC=3.1.26.5

Alternative name(s):
RNaseP protein 1

Gene names

Name:	drpp30
Synonyms:	rpp1, rpp30
ORF Names:	DDB_G0269980

Organism

Dictyostelium discoideum (Slime mold) [Reference proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	366 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends By similarity.
Catalytic activity	Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.
Subcellular location	Nucleus Potential.
Sequence similarities	Belongs to the eukaryotic/archaeal RNase P protein component 3 family.

Ontologies

Keywords
Biological process	tRNA processing
Cellular component	Nucleus
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	rRNA processing Inferred from sequence or structural similarity. Source: dictyBase tRNA processing Inferred from direct assay PubMed 17207566. Source: dictyBase
Cellular_component	nucleolar ribonuclease P complex Inferred from sequence or structural similarity PubMed 17207566. Source: dictyBase ribonuclease MRP complex Inferred from sequence or structural similarity. Source: dictyBase
Molecular_function	ribonuclease P activity Inferred from electronic annotation. Source: EC tRNA binding Inferred from direct assay PubMed 17207566. Source: dictyBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 366	366	Ribonuclease P protein subunit drpp30		PRO_0000240431
Regions
	Compositional bias	285 – 347	63	Thr-rich

Sequences

	Sequence		Length	Mass (Da)
	Q3ZE13 [UniParc]. Last modified May 2, 2006. Version 1. Checksum: 7E9B6A63EF8FB09C	FASTA	366	40,745
	10 20 30 40 50 60 MVYYDLNIDS SLPEPKIKSM LSLHTKYGYD SVAITHTVEG KIGYKDVCKI KKIQIEDDSE 70 80 90 100 110 120 KSTSSGWMKM GDSNKTIKQY TRLQVICKTM AEFQMITANN PVVQSYDIIS VVPYDVSVFN 130 140 150 160 170 180 AACNSNEIDI ITIDTFSKFI IKPERVRQCI AKGIFIEILY GNLFGIDADR IAFFQIASSL 190 200 210 220 230 240 VRSSFGKNII LSSSGKSSTT LRSPYDLSNL GHLFGLTFDQ AKAAVSKHPH TAVLHAITRR 250 260 270 280 290 300 TKGIATVTDP NLLKDLELWK LERKEDTQPT NNNIPHEKHI NKESTGKETI PKPTTTTTTT 310 320 330 340 350 360 TTTTTTAKTK TPTPTPTTEK TPSIPTQPPQ KPTAKSNKKT TTNTTSTAQK QGKMDIDIDN NKRKRE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of drpp1." Vourekas A., Kalavrizioti D., Zarkadis I.K., Stathopoulos C., Drainas D. Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: AX4.
[2]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY940192 mRNA. Translation: AAY18218.1. AAFI02000005 Genomic DNA. Translation: EAL72340.1.
RefSeq	XP_646444.1. XM_641352.1.
3D structure databases
ProteinModelPortal	Q3ZE13.
ModBase	Search...
Protein-protein interaction databases
STRING	44689.DDB_0232069.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0232069; DDB0232069; DDB_G0269980.
GeneID	8617403.
KEGG	ddi:DDB_G0269980.
Organism-specific databases
dictyBase	DDB_G0269980. drpp30.
Phylogenomic databases
eggNOG	NOG273171.
KO	K03539.
OMA	VICKTMA.
Family and domain databases
InterPro	IPR016195. Pol/histidinol_Pase-like. IPR002738. RNase_P_p30. [Graphical view]
PANTHER	PTHR13031. PTHR13031. 1 hit.
Pfam	PF01876. RNase_P_p30. 1 hit. [Graphical view]
SUPFAM	SSF89550. PHP-like. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RPP30_DICDI

Accession

Primary (citable) accession number: Q3ZE13
Secondary accession number(s): Q55CN7

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	May 2, 2006
Last modified:	May 1, 2013
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)