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Protein

CD70 antigen

Gene

CD70

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Enzyme and pathway databases

ReactomeiR-SSC-5669034. TNFs bind their physiological receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
CD70 antigen
Alternative name(s):
CD27 ligand
Short name:
CD27-L
Tumor necrosis factor ligand superfamily member 7
CD_antigen: CD70
Gene namesi
Name:CD70
Synonyms:CD27L, TNFSF7
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 17CytoplasmicSequence analysisAdd BLAST17
Transmembranei18 – 38HelicalSequence analysisAdd BLAST21
Topological domaini39 – 190ExtracellularSequence analysisAdd BLAST152

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002860001 – 190CD70 antigenAdd BLAST190

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi59N-linked (GlcNAc...)Sequence analysis1
Glycosylationi110N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi130 ↔ 148Sequence analysis
Glycosylationi167N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ3ZDR4.

Expressioni

Gene expression databases

BgeeiENSSSCG00000029950.

Interactioni

Subunit structurei

Homotrimer.Curated

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000023818.

Structurei

3D structure databases

ProteinModelPortaliQ3ZDR4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tumor necrosis factor family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IY7F. Eukaryota.
ENOG41119T2. LUCA.
GeneTreeiENSGT00390000006744.
HOGENOMiHOG000070045.
HOVERGENiHBG054184.
InParanoidiQ3ZDR4.
KOiK05470.
OMAiQVTLANC.
OrthoDBiEOG091G0QAO.
TreeFamiTF338269.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50049. TNF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3ZDR4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEEGSGCNV PRLPWASILR AALLLLLIGM VIYCFLCGQR FTQQQLDSTG
60 70 80 90 100
WDLAELLLNH TESRQDPRLR WQGSPALGRS FVHGPELDNG QLRIQRTGIY
110 120 130 140 150
RLHIQVTLTN CSSSTWTVMP RQATLTLGIC SPTTHSISLL RLNFHHTCRV
160 170 180 190
ASQRLTPLAK GDVLCTNLTL PLLPSRNADE TFFGVQLVRP
Length:190
Mass (Da):21,275
Last modified:September 27, 2005 - v1
Checksum:i092916C9A275E691
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY949027 mRNA. Translation: AAY24694.1.
RefSeqiNP_001037996.1. NM_001044531.1.
UniGeneiSsc.42649.

Genome annotation databases

EnsembliENSSSCT00000032021; ENSSSCP00000023818; ENSSSCG00000029950.
GeneIDi733577.
KEGGissc:733577.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY949027 mRNA. Translation: AAY24694.1.
RefSeqiNP_001037996.1. NM_001044531.1.
UniGeneiSsc.42649.

3D structure databases

ProteinModelPortaliQ3ZDR4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000023818.

Proteomic databases

PaxDbiQ3ZDR4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000032021; ENSSSCP00000023818; ENSSSCG00000029950.
GeneIDi733577.
KEGGissc:733577.

Organism-specific databases

CTDi970.

Phylogenomic databases

eggNOGiENOG410IY7F. Eukaryota.
ENOG41119T2. LUCA.
GeneTreeiENSGT00390000006744.
HOGENOMiHOG000070045.
HOVERGENiHBG054184.
InParanoidiQ3ZDR4.
KOiK05470.
OMAiQVTLANC.
OrthoDBiEOG091G0QAO.
TreeFamiTF338269.

Enzyme and pathway databases

ReactomeiR-SSC-5669034. TNFs bind their physiological receptors.

Gene expression databases

BgeeiENSSSCG00000029950.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50049. TNF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD70_PIG
AccessioniPrimary (citable) accession number: Q3ZDR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: September 27, 2005
Last modified: September 7, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.