Reviewed, UniProtKB/Swiss-Prot Q3ZDQ4 (ATG1_PODAN)

Names and origin

Protein names

Recommended name:
    Serine/threonine-protein kinase atg1
    EC=2.7.11.1
Alternative name(s):
    Autophagy-related protein 1

Gene names

Name:

ATG1

Organism

Podospora anserina

Taxonomic identifier

5145 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Sordariomycetidae › Sordariales › Lasiosphaeriaceae › Podospora

Protein attributes

Sequence length	941 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Serine/threonine protein kinase probably involved in the cytoplasm to vacuole transport (Cvt) and in autophagy, where it may be required for the formation of autophagosomes By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Autophagy Protein transport Transport
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Gene Ontology (GO)
Biological process	autophagy Inferred from electronic annotation. Source: UniProtKB-KW protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 941	941	Serine/threonine-protein kinase atg1		PRO_0000317797
Regions
	Domain	26 – 331	306	Protein kinase
	Nucleotide binding	32 – 40	9	ATP By similarity
Sites
	Active site	169	1	Proton acceptor By similarity
	Binding site	55	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3ZDQ4-1 [UniParc]. Last modified September 27, 2005. Version 1. Checksum: 1F79492F7F5392A3	FASTA	941	103,814
	10 20 30 40 50 60 MADRQLSSAS SSRRQKQPTD GAVGQFVIDK EIGKGSFAQV YSGRHKVTGA LVAIKSVELS 70 80 90 100 110 120 RLNKKLKENL YGEIKILKTL RHPHIVALHD CVESATHINL IMEYCELGDL SLFIKKREKL 130 140 150 160 170 180 ITHSATRDIA RRYPIEHNQG LHEVITRHFL KQLASALKFL REGNFVHRDV KPQNLLLLPS 190 200 210 220 230 240 PLFRETHHSA KQILSASYDS LMPAAGLPSL PMLKLADFGF ARVLPSTSLA ETLCGSPLYM 250 260 270 280 290 300 APEILRYERY DAKADLWSVG TVLYEMATGR PPFRAGNHVE LLRKIEAAED QVKFPRESVV 310 320 330 340 350 360 SPELKSLVRA LLKRNPVERI SFADFFNHTV ITGPIPNLHE DDLPKPEPQQ VKETVRPEGS 370 380 390 400 410 420 LSLSRRDSQR GKAATGVLSS PRPRPSSPLA TPIEKPNPLE QVPGPRAGLS YSPAGDGLGI 430 440 450 460 470 480 TRRPAVQPST SAPARPVMYV DRSRANSTAS QRPPRESIVP DPSQTLASQP RPKSRPTKPL 490 500 510 520 530 540 TEEEKAAQDV ALERDYIFID KKGVEVNALA DQISMYPQSV PKSGQIVRRA TQQGHPTSTT 550 560 570 580 590 600 GAVSARNNHL RQGSYDKPLS SSPGSTTSAI SKAIQDASLR LFGFNVAPHL LSKGQSPPQI 610 620 630 640 650 660 YSPFPAYPTP SAPAGLISDG KHTTPVDEDS RVAQCIEDWA TRSDVVYGFA EVKYKQLVPL 670 680 690 700 710 720 APSMDYGLGG VPADKMEEED GLTLEATVSL SEEALVLYVK ALSLLAKSMD IASLWWTRKS 730 740 750 760 770 780 RSDNSNSIHS AARDSVNSQA LALKINRVVQ WIRSRFNEVL EKAEIVRLKL IEAQKQLPED 790 800 810 820 830 840 HPSHPSNHQT EVSSVTGAEG VILSPGISAE KLMYDRAVEM SRTAAINEIA SEDLPGCEIF 850 860 870 880 890 900 YSTAIRMLEA VLDSDDDHLP KRRISTSSRD EKAEAAVRED TSEMSSEDKQ SIQKMIQMVK 910 920 930 940 ARLANLQKKM LAISRAQQQQ QQDIISVRRR SGEMAPRSVP V

References

[1]	"Accelerated cell death in Podospora autophagy mutants." Pinan-Lucarre B., Balguerie A., Clave C. Eukaryot. Cell 4:1765-1774(2005) [PubMed: 16278443] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY953520 mRNA. Translation: AAY28926.1.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.7.11.1. 142554.
Family and domain databases
InterPro	IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR002290. Ser_thr_pkinase. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATG1_PODAN

Accession

Primary (citable) accession number: Q3ZDQ4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	September 27, 2005
Last modified:	June 16, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)