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Protein

Zinc finger protein 568

Gene

ZNF568

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Has transcriptional repression activity, together with the corepressor TRIM28. Essential during embryonic development, where it regulates convergent extension movements required for axis elongation and tissue morphogenesis in all germ layers. Also important for normal morphogenesis of extraembryonic tissues including the yolk sac, extraembryonic mesoderm and placenta. May enhance proliferation or maintenance of neural stem cells.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri222 – 244C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri250 – 272C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri278 – 300C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri306 – 328C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri334 – 356C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri362 – 384C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri390 – 412C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri418 – 440C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri446 – 468C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri474 – 496C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri502 – 524C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri530 – 552C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri558 – 580C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri586 – 608C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri614 – 636C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-31842-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 568
Gene namesi
Name:ZNF568
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:25392. ZNF568.

Subcellular locationi

  • Nucleus By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi374900.
OpenTargetsiENSG00000198453.
PharmGKBiPA134893477.

Polymorphism and mutation databases

BioMutaiZNF568.
DMDMi158706494.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003068771 – 644Zinc finger protein 568Add BLAST644

Proteomic databases

MaxQBiQ3ZCX4.
PaxDbiQ3ZCX4.
PeptideAtlasiQ3ZCX4.
PRIDEiQ3ZCX4.

PTM databases

iPTMnetiQ3ZCX4.
PhosphoSitePlusiQ3ZCX4.

Expressioni

Gene expression databases

BgeeiENSG00000198453.
CleanExiHS_ZNF568.
ExpressionAtlasiQ3ZCX4. baseline and differential.
GenevisibleiQ3ZCX4. HS.

Organism-specific databases

HPAiHPA052061.

Interactioni

Subunit structurei

Interacts with TRIM28.By similarity

Protein-protein interaction databases

BioGridi131935. 2 interactors.
IntActiQ3ZCX4. 1 interactor.
STRINGi9606.ENSP00000334685.

Structurei

3D structure databases

ProteinModelPortaliQ3ZCX4.
SMRiQ3ZCX4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 119KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Contains 15 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri222 – 244C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri250 – 272C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri278 – 300C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri306 – 328C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri334 – 356C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri362 – 384C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri390 – 412C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri418 – 440C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri446 – 468C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri474 – 496C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri502 – 524C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri530 – 552C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri558 – 580C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri586 – 608C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri614 – 636C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133681.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ3ZCX4.
KOiK09228.
OMAiSIHKRGH.
OrthoDBiEOG091G02KC.
PhylomeDBiQ3ZCX4.
TreeFamiTF337898.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 15 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 9 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3ZCX4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTSQSSVISN SCVTMERLSH MMERKAWCSQ ESALSEEEED TTRPLETVTF
60 70 80 90 100
KDVAVDLTQE EWEQMKPAQR NLYRDVMLEN YSNLVTVGCQ VTKPDVIFKL
110 120 130 140 150
EQEEEPWVME EEMFGRHCPE VWEVDEQIKK QQETLVRKVT SISKKILIKE
160 170 180 190 200
KVIECKKVAK IFPLSSDIVT SRQSFYDCDS LDKGLEHNLD LLRYEKGCVR
210 220 230 240 250
EKQSNEFGKP FYHCASYVVT PFKCNQCGQD FSHKFDLIRH ERIHAGEKPY
260 270 280 290 300
ECKECGKAFS RKENLITHQK IHTGEKPYKC NECGKAFIQM SNLIRHHRIH
310 320 330 340 350
TGEKPYACKD CWKAFSQKSN LIEHERIHTG EKPYECKECG KSFSQKQNLI
360 370 380 390 400
EHEKIHTGEK PYACNECGRA FSRMSSVTLH MRSHTGEKPY KCNKCGKAFS
410 420 430 440 450
QCSVFIIHMR SHTGEKPYVC SECGKAFSQS SSLTVHMRNH TAEKPYECKE
460 470 480 490 500
CGKAFSRKEN LITHQKIHTG EKPYECSECG KAFIQMSNLI RHQRIHTGEK
510 520 530 540 550
PYACTVCGKA FSQKSNLTEH EKIHTGEKPY HCNQCGKAFS QRQNLLEHEK
560 570 580 590 600
IHTGEKPFKC NECGKAFSRI SSLTLHVRSH TGEKPYECNK CGKAFSQCSL
610 620 630 640
LIIHMRSHTG EKPFECNECG KAFSQRASLS IHKRGHTGER HQVY
Length:644
Mass (Da):74,369
Last modified:October 2, 2007 - v2
Checksum:iCEEED67D5D8E7DA2
GO
Isoform 2 (identifier: Q3ZCX4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-64: Missing.

Show »
Length:580
Mass (Da):67,001
Checksum:iC5CD80B13EADEEA1
GO
Isoform 3 (identifier: Q3ZCX4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-64: Missing.
     121-644: VWEVDEQIKK...GHTGERHQVY → PRRGENCCAS...KPFGGGSELS

Show »
Length:571
Mass (Da):66,602
Checksum:i38235E0D518C54A3
GO

Sequence cautioni

The sequence AAH31218 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH31218 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAE45810 differs from that shown. Reason: Frameshift at position 436.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti96V → M in AAH31218 (PubMed:15489334).Curated1
Sequence conflicti128I → V in CAE45810 (PubMed:17974005).Curated1
Isoform 3 (identifier: Q3ZCX4-3)
Sequence conflicti542L → P in BAG61554 (PubMed:14702039).Curated1

Polymorphismi

Isoform 3 is highly polymorphic with three major alleles: H, C1 and C1. The H allele is found at higher frequencies in Japanese (0.71) and Taiwan Chinese (0.72) populations compared to European (0.45) and African (0.39) populations. The H allele may be associated with smaller head size in infants.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052867437M → T.Corresponds to variant rs547483dbSNPEnsembl.1
Natural variantiVAR_052868642Q → R.Corresponds to variant rs1644634dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0285561 – 64Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST64
Alternative sequenceiVSP_046815121 – 644VWEVD…RHQVY → PRRGENCCASEVMAEGLKFK DVVIYFSQKEWECLHSAQKD LYRDVMLENYGNLVLLGLSD TKPNVISLLEQKKEPWMVKR KETKEWCPDWEFGRETKNLS PKENIYEIRSPQQEKARVIR EIRCQVERQQGHQEGHFRPA VIPFTSMQCTAHREYQWLHT GEKSCECRKCKNAFRYQSCP IQHEIIHNKEKEPECGECRK IFNSGSDLIKHQTLHESKKH SENNKCAFNHDSGITQPQSI NTGEKPHKCKECGKAFRSSS QISQHQRMHLGEKPYKCREC GKAFPSTAQLNLHQRIHTDE KYYESKACGKAFTRPSHLFR HQRIHTGEKPHKCKECGKAF RYDTQLSLHQIIHTGERRYE CRECGKVYSCASQLSLHQRI HTGEKPHECKECGKAFISDS HLIRHQSVHTGEKPCKCKEC GKSFRRGSELTRHQRAHTGE KPYECKECEKAFTCSTELVR HQKVHTGERPHKCKECGKAF IRRSELTHHERSHTGEKPYE CKECGKPFGGGSELS in isoform 3. 1 PublicationAdd BLAST524

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093123 mRNA. Translation: BAC04064.1.
AK299626 mRNA. Translation: BAG61554.1.
BX640681 mRNA. Translation: CAE45810.1. Frameshift.
AC008733 Genomic DNA. No translation available.
BC031218 mRNA. Translation: AAH31218.1. Sequence problems.
CCDSiCCDS42558.1. [Q3ZCX4-1]
CCDS56092.1. [Q3ZCX4-2]
CCDS56093.1. [Q3ZCX4-3]
RefSeqiNP_001191764.1. NM_001204835.1.
NP_001191765.1. NM_001204836.1. [Q3ZCX4-2]
NP_001191766.1. NM_001204837.1. [Q3ZCX4-2]
NP_001191767.1. NM_001204838.1.
NP_001191768.1. NM_001204839.1. [Q3ZCX4-3]
NP_940941.2. NM_198539.3. [Q3ZCX4-1]
XP_016882262.1. XM_017026773.1. [Q3ZCX4-2]
XP_016882263.1. XM_017026774.1. [Q3ZCX4-2]
XP_016882264.1. XM_017026775.1. [Q3ZCX4-3]
UniGeneiHs.404220.
Hs.733385.

Genome annotation databases

EnsembliENST00000333987; ENSP00000334685; ENSG00000198453. [Q3ZCX4-1]
ENST00000415168; ENSP00000394514; ENSG00000198453. [Q3ZCX4-2]
ENST00000455427; ENSP00000413396; ENSG00000198453. [Q3ZCX4-3]
ENST00000619231; ENSP00000481819; ENSG00000198453. [Q3ZCX4-1]
GeneIDi374900.
KEGGihsa:374900.
UCSCiuc002ofc.4. human. [Q3ZCX4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093123 mRNA. Translation: BAC04064.1.
AK299626 mRNA. Translation: BAG61554.1.
BX640681 mRNA. Translation: CAE45810.1. Frameshift.
AC008733 Genomic DNA. No translation available.
BC031218 mRNA. Translation: AAH31218.1. Sequence problems.
CCDSiCCDS42558.1. [Q3ZCX4-1]
CCDS56092.1. [Q3ZCX4-2]
CCDS56093.1. [Q3ZCX4-3]
RefSeqiNP_001191764.1. NM_001204835.1.
NP_001191765.1. NM_001204836.1. [Q3ZCX4-2]
NP_001191766.1. NM_001204837.1. [Q3ZCX4-2]
NP_001191767.1. NM_001204838.1.
NP_001191768.1. NM_001204839.1. [Q3ZCX4-3]
NP_940941.2. NM_198539.3. [Q3ZCX4-1]
XP_016882262.1. XM_017026773.1. [Q3ZCX4-2]
XP_016882263.1. XM_017026774.1. [Q3ZCX4-2]
XP_016882264.1. XM_017026775.1. [Q3ZCX4-3]
UniGeneiHs.404220.
Hs.733385.

3D structure databases

ProteinModelPortaliQ3ZCX4.
SMRiQ3ZCX4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131935. 2 interactors.
IntActiQ3ZCX4. 1 interactor.
STRINGi9606.ENSP00000334685.

PTM databases

iPTMnetiQ3ZCX4.
PhosphoSitePlusiQ3ZCX4.

Polymorphism and mutation databases

BioMutaiZNF568.
DMDMi158706494.

Proteomic databases

MaxQBiQ3ZCX4.
PaxDbiQ3ZCX4.
PeptideAtlasiQ3ZCX4.
PRIDEiQ3ZCX4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333987; ENSP00000334685; ENSG00000198453. [Q3ZCX4-1]
ENST00000415168; ENSP00000394514; ENSG00000198453. [Q3ZCX4-2]
ENST00000455427; ENSP00000413396; ENSG00000198453. [Q3ZCX4-3]
ENST00000619231; ENSP00000481819; ENSG00000198453. [Q3ZCX4-1]
GeneIDi374900.
KEGGihsa:374900.
UCSCiuc002ofc.4. human. [Q3ZCX4-1]

Organism-specific databases

CTDi374900.
DisGeNETi374900.
GeneCardsiZNF568.
HGNCiHGNC:25392. ZNF568.
HPAiHPA052061.
neXtProtiNX_Q3ZCX4.
OpenTargetsiENSG00000198453.
PharmGKBiPA134893477.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133681.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ3ZCX4.
KOiK09228.
OMAiSIHKRGH.
OrthoDBiEOG091G02KC.
PhylomeDBiQ3ZCX4.
TreeFamiTF337898.

Enzyme and pathway databases

BioCyciZFISH:G66-31842-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii374900.
PROiQ3ZCX4.

Gene expression databases

BgeeiENSG00000198453.
CleanExiHS_ZNF568.
ExpressionAtlasiQ3ZCX4. baseline and differential.
GenevisibleiQ3ZCX4. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 15 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 9 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN568_HUMAN
AccessioniPrimary (citable) accession number: Q3ZCX4
Secondary accession number(s): B4DS92
, E7ER33, Q6N060, Q8NA64
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: November 30, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.