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Protein

Zinc finger protein 568

Gene

ZNF568

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Has transcriptional repression activity, partially through the recruitment of the corepressor TRIM28 but has also repression activity independently of this interaction. Essential during embryonic development, where it acts as direct repressor of a placental-specific transcript of IGF2 in early development and regulates convergent extension movements required for axis elongation and tissue morphogenesis in all germ layers. Also important for normal morphogenesis of extraembryonic tissues including the yolk sac, extraembryonic mesoderm and placenta. May enhance proliferation or maintenance of neural stem cells.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri222 – 244C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri250 – 272C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri278 – 300C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri306 – 328C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri334 – 356C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri362 – 384C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri390 – 412C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri418 – 440C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri446 – 468C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri474 – 496C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri502 – 524C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri530 – 552C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri558 – 580C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri586 – 608C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri614 – 636C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 568
Gene namesi
Name:ZNF568
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000198453.12
HGNCiHGNC:25392 ZNF568
MIMi617566 gene
neXtProtiNX_Q3ZCX4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi374900
OpenTargetsiENSG00000198453
PharmGKBiPA134893477

Polymorphism and mutation databases

BioMutaiZNF568
DMDMi158706494

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003068771 – 644Zinc finger protein 568Add BLAST644

Proteomic databases

MaxQBiQ3ZCX4
PaxDbiQ3ZCX4
PeptideAtlasiQ3ZCX4
PRIDEiQ3ZCX4

PTM databases

iPTMnetiQ3ZCX4
PhosphoSitePlusiQ3ZCX4

Expressioni

Gene expression databases

BgeeiENSG00000198453
CleanExiHS_ZNF568
ExpressionAtlasiQ3ZCX4 baseline and differential
GenevisibleiQ3ZCX4 HS

Organism-specific databases

HPAiHPA052061

Interactioni

Subunit structurei

Interacts with TRIM28.By similarity

Protein-protein interaction databases

BioGridi131935, 2 interactors
IntActiQ3ZCX4, 1 interactor
STRINGi9606.ENSP00000334685

Structurei

3D structure databases

ProteinModelPortaliQ3ZCX4
SMRiQ3ZCX4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 119KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri222 – 244C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri250 – 272C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri278 – 300C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri306 – 328C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri334 – 356C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri362 – 384C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri390 – 412C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri418 – 440C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri446 – 468C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri474 – 496C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri502 – 524C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri530 – 552C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri558 – 580C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri586 – 608C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri614 – 636C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00900000140826
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ3ZCX4
KOiK09228
OMAiLRYEKGC
OrthoDBiEOG091G02KC
PhylomeDBiQ3ZCX4
TreeFamiTF337898

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 15 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 15 hits
PS50157 ZINC_FINGER_C2H2_2, 15 hits

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q3ZCX4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTSQSSVISN SCVTMERLSH MMERKAWCSQ ESALSEEEED TTRPLETVTF
60 70 80 90 100
KDVAVDLTQE EWEQMKPAQR NLYRDVMLEN YSNLVTVGCQ VTKPDVIFKL
110 120 130 140 150
EQEEEPWVME EEMFGRHCPE VWEVDEQIKK QQETLVRKVT SISKKILIKE
160 170 180 190 200
KVIECKKVAK IFPLSSDIVT SRQSFYDCDS LDKGLEHNLD LLRYEKGCVR
210 220 230 240 250
EKQSNEFGKP FYHCASYVVT PFKCNQCGQD FSHKFDLIRH ERIHAGEKPY
260 270 280 290 300
ECKECGKAFS RKENLITHQK IHTGEKPYKC NECGKAFIQM SNLIRHHRIH
310 320 330 340 350
TGEKPYACKD CWKAFSQKSN LIEHERIHTG EKPYECKECG KSFSQKQNLI
360 370 380 390 400
EHEKIHTGEK PYACNECGRA FSRMSSVTLH MRSHTGEKPY KCNKCGKAFS
410 420 430 440 450
QCSVFIIHMR SHTGEKPYVC SECGKAFSQS SSLTVHMRNH TAEKPYECKE
460 470 480 490 500
CGKAFSRKEN LITHQKIHTG EKPYECSECG KAFIQMSNLI RHQRIHTGEK
510 520 530 540 550
PYACTVCGKA FSQKSNLTEH EKIHTGEKPY HCNQCGKAFS QRQNLLEHEK
560 570 580 590 600
IHTGEKPFKC NECGKAFSRI SSLTLHVRSH TGEKPYECNK CGKAFSQCSL
610 620 630 640
LIIHMRSHTG EKPFECNECG KAFSQRASLS IHKRGHTGER HQVY
Length:644
Mass (Da):74,369
Last modified:October 2, 2007 - v2
Checksum:iCEEED67D5D8E7DA2
GO
Isoform 2 (identifier: Q3ZCX4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-64: Missing.

Show »
Length:580
Mass (Da):67,001
Checksum:iC5CD80B13EADEEA1
GO
Isoform 3 (identifier: Q3ZCX4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-64: Missing.
     121-644: VWEVDEQIKK...GHTGERHQVY → PRRGENCCAS...KPFGGGSELS

Show »
Length:571
Mass (Da):66,602
Checksum:i38235E0D518C54A3
GO

Sequence cautioni

The sequence AAH31218 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH31218 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAE45810 differs from that shown. Reason: Frameshift at position 436.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti96V → M in AAH31218 (PubMed:15489334).Curated1
Sequence conflicti128I → V in CAE45810 (PubMed:17974005).Curated1
Isoform 3 (identifier: Q3ZCX4-3)
Sequence conflicti542L → P in BAG61554 (PubMed:14702039).Curated1

Polymorphismi

Isoform 3 is highly polymorphic with three major alleles: H, C1 and C1. The H allele is found at higher frequencies in Japanese (0.71) and Taiwan Chinese (0.72) populations compared to European (0.45) and African (0.39) populations. The H allele may be associated with smaller head size in infants.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052867437M → T. Corresponds to variant dbSNP:rs547483Ensembl.1
Natural variantiVAR_052868642Q → R. Corresponds to variant dbSNP:rs1644634Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0285561 – 64Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST64
Alternative sequenceiVSP_046815121 – 644VWEVD…RHQVY → PRRGENCCASEVMAEGLKFK DVVIYFSQKEWECLHSAQKD LYRDVMLENYGNLVLLGLSD TKPNVISLLEQKKEPWMVKR KETKEWCPDWEFGRETKNLS PKENIYEIRSPQQEKARVIR EIRCQVERQQGHQEGHFRPA VIPFTSMQCTAHREYQWLHT GEKSCECRKCKNAFRYQSCP IQHEIIHNKEKEPECGECRK IFNSGSDLIKHQTLHESKKH SENNKCAFNHDSGITQPQSI NTGEKPHKCKECGKAFRSSS QISQHQRMHLGEKPYKCREC GKAFPSTAQLNLHQRIHTDE KYYESKACGKAFTRPSHLFR HQRIHTGEKPHKCKECGKAF RYDTQLSLHQIIHTGERRYE CRECGKVYSCASQLSLHQRI HTGEKPHECKECGKAFISDS HLIRHQSVHTGEKPCKCKEC GKSFRRGSELTRHQRAHTGE KPYECKECEKAFTCSTELVR HQKVHTGERPHKCKECGKAF IRRSELTHHERSHTGEKPYE CKECGKPFGGGSELS in isoform 3. 1 PublicationAdd BLAST524

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093123 mRNA Translation: BAC04064.1
AK299626 mRNA Translation: BAG61554.1
BX640681 mRNA Translation: CAE45810.1 Frameshift.
AC008733 Genomic DNA No translation available.
BC031218 mRNA Translation: AAH31218.1 Sequence problems.
CCDSiCCDS42558.1 [Q3ZCX4-1]
CCDS56092.1 [Q3ZCX4-2]
CCDS56093.1 [Q3ZCX4-3]
RefSeqiNP_001191764.1, NM_001204835.1
NP_001191765.1, NM_001204836.1 [Q3ZCX4-2]
NP_001191766.1, NM_001204837.1 [Q3ZCX4-2]
NP_001191767.1, NM_001204838.1
NP_001191768.1, NM_001204839.1 [Q3ZCX4-3]
NP_940941.2, NM_198539.3 [Q3ZCX4-1]
XP_016882262.1, XM_017026773.1 [Q3ZCX4-2]
XP_016882263.1, XM_017026774.1 [Q3ZCX4-2]
XP_016882264.1, XM_017026775.1 [Q3ZCX4-3]
UniGeneiHs.404220
Hs.733385

Genome annotation databases

EnsembliENST00000333987; ENSP00000334685; ENSG00000198453 [Q3ZCX4-1]
ENST00000415168; ENSP00000394514; ENSG00000198453 [Q3ZCX4-2]
ENST00000455427; ENSP00000413396; ENSG00000198453 [Q3ZCX4-3]
ENST00000619231; ENSP00000481819; ENSG00000198453 [Q3ZCX4-1]
GeneIDi374900
KEGGihsa:374900
UCSCiuc002ofc.4 human [Q3ZCX4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN568_HUMAN
AccessioniPrimary (citable) accession number: Q3ZCX4
Secondary accession number(s): B4DS92
, E7ER33, Q6N060, Q8NA64
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: May 23, 2018
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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