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Protein

Galectin-related protein

Gene

LGALSL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Does not bind lactose, and may not bind carbohydrates.2 Publications

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Galectin-related protein
Alternative name(s):
Lectin galactoside-binding-like protein
Gene namesi
Name:LGALSL
Synonyms:GRP
ORF Names:HSPC159
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:25012. LGALSL.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi29094.
OpenTargetsiENSG00000119862.

Polymorphism and mutation databases

BioMutaiLGALSL.
DMDMi166223243.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00003157662 – 172Galectin-related proteinAdd BLAST171

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei22PhosphoserineCombined sources1
Modified residuei25PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ3ZCW2.
MaxQBiQ3ZCW2.
PaxDbiQ3ZCW2.
PeptideAtlasiQ3ZCW2.
PRIDEiQ3ZCW2.

2D gel databases

REPRODUCTION-2DPAGEIPI00023549.

PTM databases

iPTMnetiQ3ZCW2.
PhosphoSitePlusiQ3ZCW2.

Expressioni

Gene expression databases

BgeeiENSG00000119862.
ExpressionAtlasiQ3ZCW2. baseline and differential.
GenevisibleiQ3ZCW2. HS.

Organism-specific databases

HPAiHPA046079.

Interactioni

Subunit structurei

Monomer.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
MAD1L1Q9Y6D95EBI-10241423,EBI-742610
TINF2Q9BSI42EBI-10241423,EBI-717399

Protein-protein interaction databases

BioGridi118863. 6 interactors.
IntActiQ3ZCW2. 5 interactors.
MINTiMINT-4715048.
STRINGi9606.ENSP00000238875.

Structurei

Secondary structure

1172
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi40 – 43Combined sources4
Beta strandi53 – 60Combined sources8
Beta strandi66 – 74Combined sources9
Turni77 – 80Combined sources4
Beta strandi82 – 90Combined sources9
Turni91 – 94Combined sources4
Beta strandi95 – 102Combined sources8
Beta strandi123 – 130Combined sources8
Beta strandi132 – 139Combined sources8
Beta strandi142 – 148Combined sources7
Helixi154 – 156Combined sources3
Beta strandi159 – 172Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JJ6X-ray2.00A/B38-171[»]
3B9CX-ray1.90A/B/C/D38-172[»]
ProteinModelPortaliQ3ZCW2.
SMRiQ3ZCW2.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ3ZCW2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 168GalectinPROSITE-ProRule annotationAdd BLAST130

Sequence similaritiesi

Contains 1 galectin domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3587. Eukaryota.
ENOG4111EA0. LUCA.
GeneTreeiENSGT00760000119105.
HOGENOMiHOG000293279.
HOVERGENiHBG006255.
InParanoidiQ3ZCW2.
OMAiTAYFPFI.
OrthoDBiEOG091G0O5V.
PhylomeDBiQ3ZCW2.
TreeFamiTF315551.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR030651. Galectin-rel.
IPR001079. Galectin_CRD.
[Graphical view]
PANTHERiPTHR11346:SF98. PTHR11346:SF98. 1 hit.
PfamiPF00337. Gal-bind_lectin. 1 hit.
[Graphical view]
SMARTiSM00908. Gal-bind_lectin. 1 hit.
SM00276. GLECT. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS51304. GALECTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3ZCW2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGSVADSDA VVKLDDGHLN NSLSSPVQAD VYFPRLIVPF CGHIKGGMRP
60 70 80 90 100
GKKVLVMGIV DLNPESFAIS LTCGDSEDPP ADVAIELKAV FTDRQLLRNS
110 120 130 140 150
CISGERGEEQ SAIPYFPFIP DQPFRVEILC EHPRFRVFVD GHQLFDFYHR
160 170
IQTLSAIDTI KINGDLQITK LG
Length:172
Mass (Da):18,986
Last modified:January 15, 2008 - v2
Checksum:iE2D41EA68EF44DEC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti132H → Y in AAF29123 (PubMed:11042152).Curated1
Sequence conflicti136R → G in AAH36082 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161508 mRNA. Translation: AAF29123.1.
AK314656 mRNA. Translation: BAG37215.1.
CH471053 Genomic DNA. Translation: EAW99942.1.
CH471053 Genomic DNA. Translation: EAW99943.1.
BC036082 mRNA. Translation: AAH36082.1.
BC062691 mRNA. Translation: AAH62691.1.
CCDSiCCDS1877.1.
RefSeqiNP_054900.2. NM_014181.2.
UniGeneiHs.372208.

Genome annotation databases

EnsembliENST00000238875; ENSP00000238875; ENSG00000119862.
GeneIDi29094.
KEGGihsa:29094.
UCSCiuc002scy.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161508 mRNA. Translation: AAF29123.1.
AK314656 mRNA. Translation: BAG37215.1.
CH471053 Genomic DNA. Translation: EAW99942.1.
CH471053 Genomic DNA. Translation: EAW99943.1.
BC036082 mRNA. Translation: AAH36082.1.
BC062691 mRNA. Translation: AAH62691.1.
CCDSiCCDS1877.1.
RefSeqiNP_054900.2. NM_014181.2.
UniGeneiHs.372208.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JJ6X-ray2.00A/B38-171[»]
3B9CX-ray1.90A/B/C/D38-172[»]
ProteinModelPortaliQ3ZCW2.
SMRiQ3ZCW2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118863. 6 interactors.
IntActiQ3ZCW2. 5 interactors.
MINTiMINT-4715048.
STRINGi9606.ENSP00000238875.

PTM databases

iPTMnetiQ3ZCW2.
PhosphoSitePlusiQ3ZCW2.

Polymorphism and mutation databases

BioMutaiLGALSL.
DMDMi166223243.

2D gel databases

REPRODUCTION-2DPAGEIPI00023549.

Proteomic databases

EPDiQ3ZCW2.
MaxQBiQ3ZCW2.
PaxDbiQ3ZCW2.
PeptideAtlasiQ3ZCW2.
PRIDEiQ3ZCW2.

Protocols and materials databases

DNASUi29094.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000238875; ENSP00000238875; ENSG00000119862.
GeneIDi29094.
KEGGihsa:29094.
UCSCiuc002scy.5. human.

Organism-specific databases

CTDi29094.
DisGeNETi29094.
GeneCardsiLGALSL.
H-InvDBHIX0002099.
HGNCiHGNC:25012. LGALSL.
HPAiHPA046079.
neXtProtiNX_Q3ZCW2.
OpenTargetsiENSG00000119862.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3587. Eukaryota.
ENOG4111EA0. LUCA.
GeneTreeiENSGT00760000119105.
HOGENOMiHOG000293279.
HOVERGENiHBG006255.
InParanoidiQ3ZCW2.
OMAiTAYFPFI.
OrthoDBiEOG091G0O5V.
PhylomeDBiQ3ZCW2.
TreeFamiTF315551.

Miscellaneous databases

EvolutionaryTraceiQ3ZCW2.
GeneWikiiHSPC159.
GenomeRNAii29094.
PROiQ3ZCW2.

Gene expression databases

BgeeiENSG00000119862.
ExpressionAtlasiQ3ZCW2. baseline and differential.
GenevisibleiQ3ZCW2. HS.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR030651. Galectin-rel.
IPR001079. Galectin_CRD.
[Graphical view]
PANTHERiPTHR11346:SF98. PTHR11346:SF98. 1 hit.
PfamiPF00337. Gal-bind_lectin. 1 hit.
[Graphical view]
SMARTiSM00908. Gal-bind_lectin. 1 hit.
SM00276. GLECT. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS51304. GALECTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLEGL_HUMAN
AccessioniPrimary (citable) accession number: Q3ZCW2
Secondary accession number(s): B2RBG8
, D6W5E8, Q6P5T6, Q9P005
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: November 30, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Most of the residues in the galectin domain that have been shown to be critical for carbohydrate-binding in other galectins are not conserved.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.