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Protein

Zinc finger protein 260

Gene

ZNF260

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. Binds to PE response elements (PERE) present in the promoter of genes such as ANF/NPPA and acts as a direct transcriptional activator of NPPA. Also acts as a cofactor with GATA4, a key cardiac regulator (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri27 – 4923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri55 – 7723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri83 – 10523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri136 – 15823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri164 – 18623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri192 – 21423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri220 – 24223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri248 – 27023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri276 – 29823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri304 – 32623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri332 – 35423C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri360 – 38223C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri388 – 41225C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 260
Short name:
Zfp-260
Gene namesi
Name:ZNF260
Synonyms:ZFP260
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:13499. ZNF260.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145147548.

Polymorphism and mutation databases

BioMutaiZNF260.
DMDMi215274187.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 412412Zinc finger protein 260PRO_0000047320Add
BLAST

Proteomic databases

PaxDbiQ3ZCT1.
PeptideAtlasiQ3ZCT1.
PRIDEiQ3ZCT1.

PTM databases

iPTMnetiQ3ZCT1.
PhosphoSiteiQ3ZCT1.

Expressioni

Inductioni

Up-regulated by activation of alpha1-adrenergic receptors.1 Publication

Gene expression databases

BgeeiENSG00000254004.
CleanExiHS_ZNF260.
GenevisibleiQ3ZCT1. HS.

Organism-specific databases

HPAiHPA028806.

Interactioni

Subunit structurei

Binds DNA. Interacts with GATA4 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
NDEL1Q9GZM83EBI-10241410,EBI-928842

Protein-protein interaction databases

BioGridi130868. 3 interactions.
IntActiQ3ZCT1. 1 interaction.
STRINGi9606.ENSP00000429803.

Structurei

3D structure databases

ProteinModelPortaliQ3ZCT1.
SMRiQ3ZCT1. Positions 24-411.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri27 – 4923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri55 – 7723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri83 – 10523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri136 – 15823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri164 – 18623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri192 – 21423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri220 – 24223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri248 – 27023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri276 – 29823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri304 – 32623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri332 – 35423C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri360 – 38223C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri388 – 41225C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129808.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ3ZCT1.
OMAiYECGKAS.
OrthoDBiEOG091G02KC.
PhylomeDBiQ3ZCT1.
TreeFamiTF341817.

Family and domain databases

Gene3Di3.30.160.60. 15 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 4 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 14 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3ZCT1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIGMLESLQH ESDLLQHDQI HTGEKPYECN ECRKTFSLKQ NLVEHKKMHT
60 70 80 90 100
GEKSHECTEC GKVCSRVSSL TLHLRSHTGK KAYKCNKCGK AFSQKENFLS
110 120 130 140 150
HQKHHTGEKP YECEKVSIQM PTIIRHQKNH TGTKPYACKE CGKAFNGKAY
160 170 180 190 200
LTEHEKIHTG EKPFECNQCG RAFSQKQYLI KHQNIHTGKK PFKCSECGKA
210 220 230 240 250
FSQKENLIIH QRIHTGEKPY ECKGCGKAFI QKSSLIRHQR SHTGEKPYTC
260 270 280 290 300
KECGKAFSGK SNLTEHEKIH IGEKPYKCNE CGTIFRQKQY LIKHHNIHTG
310 320 330 340 350
EKPYECNKCG KAFSRITSLI VHVRIHTGDK PYECKVCGKA FCQSSSLTVH
360 370 380 390 400
MRSHTGEKPY GCNECGKAFS QFSTLALHMR IHTGEKPYQC SECGKAFSQK
410
SHHIRHQRIH TH
Length:412
Mass (Da):47,222
Last modified:November 25, 2008 - v3
Checksum:iD3943F148FD9C77C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC092295 Genomic DNA. No translation available.
BC042676 mRNA. Translation: AAH42676.1.
BC119003 mRNA. Translation: AAI19004.1.
BC122549 mRNA. Translation: AAI22550.1.
CCDSiCCDS33003.1.
RefSeqiNP_001012774.1. NM_001012756.2.
NP_001159508.1. NM_001166036.1.
NP_001159509.1. NM_001166037.1.
NP_001159510.1. NM_001166038.1.
XP_011525199.1. XM_011526897.2.
UniGeneiHs.18103.

Genome annotation databases

EnsembliENST00000523638; ENSP00000429803; ENSG00000254004.
ENST00000588993; ENSP00000467219; ENSG00000254004.
ENST00000592282; ENSP00000464964; ENSG00000254004.
ENST00000593142; ENSP00000465834; ENSG00000254004.
GeneIDi339324.
KEGGihsa:339324.
UCSCiuc002oee.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC092295 Genomic DNA. No translation available.
BC042676 mRNA. Translation: AAH42676.1.
BC119003 mRNA. Translation: AAI19004.1.
BC122549 mRNA. Translation: AAI22550.1.
CCDSiCCDS33003.1.
RefSeqiNP_001012774.1. NM_001012756.2.
NP_001159508.1. NM_001166036.1.
NP_001159509.1. NM_001166037.1.
NP_001159510.1. NM_001166038.1.
XP_011525199.1. XM_011526897.2.
UniGeneiHs.18103.

3D structure databases

ProteinModelPortaliQ3ZCT1.
SMRiQ3ZCT1. Positions 24-411.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130868. 3 interactions.
IntActiQ3ZCT1. 1 interaction.
STRINGi9606.ENSP00000429803.

PTM databases

iPTMnetiQ3ZCT1.
PhosphoSiteiQ3ZCT1.

Polymorphism and mutation databases

BioMutaiZNF260.
DMDMi215274187.

Proteomic databases

PaxDbiQ3ZCT1.
PeptideAtlasiQ3ZCT1.
PRIDEiQ3ZCT1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000523638; ENSP00000429803; ENSG00000254004.
ENST00000588993; ENSP00000467219; ENSG00000254004.
ENST00000592282; ENSP00000464964; ENSG00000254004.
ENST00000593142; ENSP00000465834; ENSG00000254004.
GeneIDi339324.
KEGGihsa:339324.
UCSCiuc002oee.3. human.

Organism-specific databases

CTDi339324.
GeneCardsiZNF260.
HGNCiHGNC:13499. ZNF260.
HPAiHPA028806.
MIMi613749. gene.
neXtProtiNX_Q3ZCT1.
PharmGKBiPA145147548.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129808.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ3ZCT1.
OMAiYECGKAS.
OrthoDBiEOG091G02KC.
PhylomeDBiQ3ZCT1.
TreeFamiTF341817.

Miscellaneous databases

GenomeRNAii339324.
PROiQ3ZCT1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000254004.
CleanExiHS_ZNF260.
GenevisibleiQ3ZCT1. HS.

Family and domain databases

Gene3Di3.30.160.60. 15 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 4 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 14 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN260_HUMAN
AccessioniPrimary (citable) accession number: Q3ZCT1
Secondary accession number(s): Q0VF43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 25, 2008
Last modified: September 7, 2016
This is version 100 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-4 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.