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Q3ZCQ2

- AX2R_HUMAN

UniProt

Q3ZCQ2 - AX2R_HUMAN

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Protein

Annexin-2 receptor

Gene
ANXA2R, AX2R, C5orf39
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

May act as a receptor for annexin II on marrow stromal cells to induce osteoclast formation.1 Publication

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin-2 receptor
Alternative name(s):
Annexin II receptor
Short name:
AXIIR
Gene namesi
Name:ANXA2R
Synonyms:AX2R, C5orf39
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:33463. ANXA2R.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162380171.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 193193Annexin-2 receptorPRO_0000295727Add
BLAST

Proteomic databases

PRIDEiQ3ZCQ2.

Expressioni

Tissue specificityi

Widely expressed. Highly expressed in lymphocytes. Expressed in both resting CD4+ and CD8+ T-cells.1 Publication

Gene expression databases

BgeeiQ3ZCQ2.
CleanExiHS_C5orf39.
GenevestigatoriQ3ZCQ2.

Organism-specific databases

HPAiHPA051482.

Interactioni

Protein-protein interaction databases

BioGridi133074. 1 interaction.
STRINGi9606.ENSP00000315915.

Structurei

3D structure databases

ProteinModelPortaliQ3ZCQ2.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG78262.
HOGENOMiHOG000169180.
InParanoidiQ3ZCQ2.
OMAiLSSPCWR.
OrthoDBiEOG7D85XK.
PhylomeDBiQ3ZCQ2.
TreeFamiTF342039.

Sequencei

Sequence statusi: Complete.

Q3ZCQ2-1 [UniParc]FASTAAdd to Basket

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MEQHFLGCVK RAWDSAEVAP EPQPPPIVSS EDRGPWPLPL YPVLGEYSLD    50
SCDLGLLSSP CWRLPGVYWQ NGLSPGVQST LEPSTAKPTE FSWPGTQKQQ 100
EAPVEEVGQA EEPDRLRLQQ LPWSSPLHPW DRQQDTEVCD SGCLLERRHP 150
PALQPWRHLP GFSDCLEWIL RVGFAAFSVL WACCSRICGA KQP 193
Length:193
Mass (Da):21,682
Last modified:May 18, 2010 - v2
Checksum:i6BBC734AB14CE32F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti119 – 1191Q → R.1 Publication
Corresponds to variant rs1054428 [ dbSNP | Ensembl ].
VAR_033348
Natural varianti186 – 1861R → W.
Corresponds to variant rs10971 [ dbSNP | Ensembl ].
VAR_033349

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY032883 mRNA. Translation: AAK52335.1.
AC025171 Genomic DNA. No translation available.
BC067873 mRNA. Translation: AAH67873.1.
CCDSiCCDS34153.1.
RefSeqiNP_001014301.1. NM_001014279.2.
UniGeneiHs.529385.

Genome annotation databases

EnsembliENST00000314890; ENSP00000315915; ENSG00000177721.
GeneIDi389289.
KEGGihsa:389289.
UCSCiuc003jnf.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY032883 mRNA. Translation: AAK52335.1 .
AC025171 Genomic DNA. No translation available.
BC067873 mRNA. Translation: AAH67873.1 .
CCDSi CCDS34153.1.
RefSeqi NP_001014301.1. NM_001014279.2.
UniGenei Hs.529385.

3D structure databases

ProteinModelPortali Q3ZCQ2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 133074. 1 interaction.
STRINGi 9606.ENSP00000315915.

Proteomic databases

PRIDEi Q3ZCQ2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000314890 ; ENSP00000315915 ; ENSG00000177721 .
GeneIDi 389289.
KEGGi hsa:389289.
UCSCi uc003jnf.3. human.

Organism-specific databases

CTDi 389289.
GeneCardsi GC05M043042.
HGNCi HGNC:33463. ANXA2R.
HPAi HPA051482.
MIMi 611296. gene.
neXtProti NX_Q3ZCQ2.
PharmGKBi PA162380171.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG78262.
HOGENOMi HOG000169180.
InParanoidi Q3ZCQ2.
OMAi LSSPCWR.
OrthoDBi EOG7D85XK.
PhylomeDBi Q3ZCQ2.
TreeFami TF342039.

Miscellaneous databases

GenomeRNAii 389289.
NextBioi 102755.
PROi Q3ZCQ2.
SOURCEi Search...

Gene expression databases

Bgeei Q3ZCQ2.
CleanExi HS_C5orf39.
Genevestigatori Q3ZCQ2.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of the annexin II receptor on human marrow stromal cells."
    Lu G., Maeda H., Reddy S.V., Kurihara N., Leach R., Anderson J.L., Roodman G.D.
    J. Biol. Chem. 281:30542-30550(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], POSSIBLE FUNCTION, TISSUE SPECIFICITY.
    Tissue: Bone marrow.
  2. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-119.
    Tissue: Placenta.
  4. "Annexin II increases osteoclast formation by stimulating the proliferation of osteoclast precursors in human marrow cultures."
    Menaa C., Devlin R.D., Reddy S.V., Gazitt Y., Choi S.J., Roodman G.D.
    J. Clin. Invest. 103:1605-1613(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiAX2R_HUMAN
AccessioniPrimary (citable) accession number: Q3ZCQ2
Secondary accession number(s): Q8NHX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 61 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

1 Publication reports that it is a type I membrane protein. However, no clear transmembrane region is detected by prediction methods, suggesting that its localization at the plasma membrane is unsure.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

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