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Protein

Annexin-2 receptor

Gene

ANXA2R

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as a receptor for annexin II on marrow stromal cells to induce osteoclast formation.

Caution

PubMed:16895901 reports that it is a type I membrane protein. However, no clear transmembrane region is detected by prediction methods, suggesting that its localization at the plasma membrane is unsure.Curated

GO - Molecular functioni

Keywordsi

Molecular functionReceptor

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin-2 receptor
Alternative name(s):
Annexin II receptor
Short name:
AXIIR
Gene namesi
Name:ANXA2R
Synonyms:AX2R, C5orf39
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000177721.4
HGNCiHGNC:33463 ANXA2R
MIMi611296 gene
neXtProtiNX_Q3ZCQ2

Pathology & Biotechi

Organism-specific databases

DisGeNETi389289
OpenTargetsiENSG00000177721
PharmGKBiPA162380171

Polymorphism and mutation databases

BioMutaiANXA2R

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002957271 – 193Annexin-2 receptorAdd BLAST193

Proteomic databases

PaxDbiQ3ZCQ2
PeptideAtlasiQ3ZCQ2
PRIDEiQ3ZCQ2

PTM databases

iPTMnetiQ3ZCQ2
PhosphoSitePlusiQ3ZCQ2

Expressioni

Tissue specificityi

Widely expressed. Highly expressed in lymphocytes. Expressed in both resting CD4+ and CD8+ T-cells.1 Publication

Gene expression databases

BgeeiENSG00000177721
CleanExiHS_C5orf39
GenevisibleiQ3ZCQ2 HS

Organism-specific databases

HPAiHPA051482

Interactioni

Protein-protein interaction databases

BioGridi133074, 1 interactor
STRINGi9606.ENSP00000315915

Structurei

3D structure databases

ProteinModelPortaliQ3ZCQ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410J4VK Eukaryota
ENOG41115P8 LUCA
GeneTreeiENSGT00390000009290
HOGENOMiHOG000169180
InParanoidiQ3ZCQ2
OMAiICGAKQP
OrthoDBiEOG091G0L8I
PhylomeDBiQ3ZCQ2
TreeFamiTF342039

Family and domain databases

InterProiView protein in InterPro
IPR031449 ANXA2R
PANTHERiPTHR38820 PTHR38820, 1 hit
PfamiView protein in Pfam
PF15721 ANXA2R, 1 hit

Sequencei

Sequence statusi: Complete.

Q3ZCQ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQHFLGCVK RAWDSAEVAP EPQPPPIVSS EDRGPWPLPL YPVLGEYSLD
60 70 80 90 100
SCDLGLLSSP CWRLPGVYWQ NGLSPGVQST LEPSTAKPTE FSWPGTQKQQ
110 120 130 140 150
EAPVEEVGQA EEPDRLRLQQ LPWSSPLHPW DRQQDTEVCD SGCLLERRHP
160 170 180 190
PALQPWRHLP GFSDCLEWIL RVGFAAFSVL WACCSRICGA KQP
Length:193
Mass (Da):21,682
Last modified:May 18, 2010 - v2
Checksum:i6BBC734AB14CE32F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033348119Q → R1 PublicationCorresponds to variant dbSNP:rs1054428Ensembl.1
Natural variantiVAR_033349186R → W. Corresponds to variant dbSNP:rs10971Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY032883 mRNA Translation: AAK52335.1
AC025171 Genomic DNA No translation available.
BC067873 mRNA Translation: AAH67873.1
CCDSiCCDS34153.1
RefSeqiNP_001014301.1, NM_001014279.2
UniGeneiHs.529385

Genome annotation databases

EnsembliENST00000314890; ENSP00000315915; ENSG00000177721
ENST00000616064; ENSP00000479862; ENSG00000177721
GeneIDi389289
KEGGihsa:389289
UCSCiuc003jnf.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiAX2R_HUMAN
AccessioniPrimary (citable) accession number: Q3ZCQ2
Secondary accession number(s): Q8NHX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: May 18, 2010
Last modified: May 23, 2018
This is version 79 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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Main funding by: National Institutes of Health