Q3ZCQ2 (AX2R_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Annexin-2 receptor

Alternative name(s):
Annexin II receptor
Short name=AXIIR

Gene names

Name:	ANXA2R
Synonyms:	AX2R, C5orf39

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	193 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May act as a receptor for annexin II on marrow stromal cells to induce osteoclast formation. Ref.1
Tissue specificity	Widely expressed. Highly expressed in lymphocytes. Expressed in both resting CD4+ and CD8+ T-cells. Ref.1
Caution	Ref.1 reports that it is a type I membrane protein. However, no clear transmembrane region is detected by prediction methods, suggesting that its localization at the plasma membrane is unsure.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Molecular function	Receptor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 193	193	Annexin-2 receptor		PRO_0000295727
Natural variations
	Natural variant	119	1	Q → R. Ref.3 Corresponds to variant rs1054428 [ dbSNP | Ensembl ].		VAR_033348
	Natural variant	186	1	R → W. Corresponds to variant rs10971 [ dbSNP | Ensembl ].		VAR_033349

Sequences

	Sequence		Length	Mass (Da)
	Q3ZCQ2 [UniParc]. Last modified May 18, 2010. Version 2. Checksum: 6BBC734AB14CE32F	FASTA	193	21,682
	10 20 30 40 50 60 MEQHFLGCVK RAWDSAEVAP EPQPPPIVSS EDRGPWPLPL YPVLGEYSLD SCDLGLLSSP 70 80 90 100 110 120 CWRLPGVYWQ NGLSPGVQST LEPSTAKPTE FSWPGTQKQQ EAPVEEVGQA EEPDRLRLQQ 130 140 150 160 170 180 LPWSSPLHPW DRQQDTEVCD SGCLLERRHP PALQPWRHLP GFSDCLEWIL RVGFAAFSVL 190 WACCSRICGA KQP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of the annexin II receptor on human marrow stromal cells." Lu G., Maeda H., Reddy S.V., Kurihara N., Leach R., Anderson J.L., Roodman G.D. J. Biol. Chem. 281:30542-30550(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], POSSIBLE FUNCTION, TISSUE SPECIFICITY. Tissue: Bone marrow.
[2]	"The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M. Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-119. Tissue: Placenta.
[4]	"Annexin II increases osteoclast formation by stimulating the proliferation of osteoclast precursors in human marrow cultures." Menaa C., Devlin R.D., Reddy S.V., Gazitt Y., Choi S.J., Roodman G.D. J. Clin. Invest. 103:1605-1613(1999) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY032883 mRNA. Translation: AAK52335.1. AC025171 Genomic DNA. No translation available. BC067873 mRNA. Translation: AAH67873.1.
IPI	IPI00169368.
RefSeq	NP_001014301.1. NM_001014279.2.
UniGene	Hs.529385.
3D structure databases
ProteinModelPortal	Q3ZCQ2.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000315915.
Proteomic databases
PRIDE	Q3ZCQ2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000314890; ENSP00000315915; ENSG00000177721.
GeneID	389289.
KEGG	hsa:389289.
UCSC	uc003jnf.3. human.
Organism-specific databases
CTD	389289.
GeneCards	GC05M043042.
HGNC	HGNC:33463. ANXA2R.
HPA	HPA051482.
MIM	611296. gene.
neXtProt	NX_Q3ZCQ2.
PharmGKB	PA162380171.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG78262.
HOGENOM	HOG000169180.
InParanoid	Q3ZCQ2.
OMA	LSSPCWR.
OrthoDB	EOG4JT06H.
PhylomeDB	Q3ZCQ2.
Gene expression databases
Bgee	Q3ZCQ2.
CleanEx	HS_C5orf39.
Genevestigator	Q3ZCQ2.
Family and domain databases
ProtoNet	Search...
Other
GenomeRNAi	389289.
NextBio	102755.
SOURCE	Search...

Entry information

Entry name

AX2R_HUMAN

Accession

Primary (citable) accession number: Q3ZCQ2
Secondary accession number(s): Q8NHX5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 24, 2007
Last sequence update:	May 18, 2010
Last modified:	May 1, 2013
This is version 56 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.