Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q3ZCQ2

- AX2R_HUMAN

UniProt

Q3ZCQ2 - AX2R_HUMAN

Protein

Annexin-2 receptor

Gene

ANXA2R

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May act as a receptor for annexin II on marrow stromal cells to induce osteoclast formation.

    Keywords - Molecular functioni

    Receptor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Annexin-2 receptor
    Alternative name(s):
    Annexin II receptor
    Short name:
    AXIIR
    Gene namesi
    Name:ANXA2R
    Synonyms:AX2R, C5orf39
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:33463. ANXA2R.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162380171.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 193193Annexin-2 receptorPRO_0000295727Add
    BLAST

    Proteomic databases

    PRIDEiQ3ZCQ2.

    Expressioni

    Tissue specificityi

    Widely expressed. Highly expressed in lymphocytes. Expressed in both resting CD4+ and CD8+ T-cells.1 Publication

    Gene expression databases

    BgeeiQ3ZCQ2.
    CleanExiHS_C5orf39.
    GenevestigatoriQ3ZCQ2.

    Organism-specific databases

    HPAiHPA051482.

    Interactioni

    Protein-protein interaction databases

    BioGridi133074. 1 interaction.
    STRINGi9606.ENSP00000315915.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3ZCQ2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG78262.
    HOGENOMiHOG000169180.
    InParanoidiQ3ZCQ2.
    OMAiLSSPCWR.
    OrthoDBiEOG7D85XK.
    PhylomeDBiQ3ZCQ2.
    TreeFamiTF342039.

    Sequencei

    Sequence statusi: Complete.

    Q3ZCQ2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEQHFLGCVK RAWDSAEVAP EPQPPPIVSS EDRGPWPLPL YPVLGEYSLD    50
    SCDLGLLSSP CWRLPGVYWQ NGLSPGVQST LEPSTAKPTE FSWPGTQKQQ 100
    EAPVEEVGQA EEPDRLRLQQ LPWSSPLHPW DRQQDTEVCD SGCLLERRHP 150
    PALQPWRHLP GFSDCLEWIL RVGFAAFSVL WACCSRICGA KQP 193
    Length:193
    Mass (Da):21,682
    Last modified:May 18, 2010 - v2
    Checksum:i6BBC734AB14CE32F
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti119 – 1191Q → R.1 Publication
    Corresponds to variant rs1054428 [ dbSNP | Ensembl ].
    VAR_033348
    Natural varianti186 – 1861R → W.
    Corresponds to variant rs10971 [ dbSNP | Ensembl ].
    VAR_033349

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY032883 mRNA. Translation: AAK52335.1.
    AC025171 Genomic DNA. No translation available.
    BC067873 mRNA. Translation: AAH67873.1.
    CCDSiCCDS34153.1.
    RefSeqiNP_001014301.1. NM_001014279.2.
    UniGeneiHs.529385.

    Genome annotation databases

    EnsembliENST00000314890; ENSP00000315915; ENSG00000177721.
    GeneIDi389289.
    KEGGihsa:389289.
    UCSCiuc003jnf.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY032883 mRNA. Translation: AAK52335.1 .
    AC025171 Genomic DNA. No translation available.
    BC067873 mRNA. Translation: AAH67873.1 .
    CCDSi CCDS34153.1.
    RefSeqi NP_001014301.1. NM_001014279.2.
    UniGenei Hs.529385.

    3D structure databases

    ProteinModelPortali Q3ZCQ2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 133074. 1 interaction.
    STRINGi 9606.ENSP00000315915.

    Proteomic databases

    PRIDEi Q3ZCQ2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000314890 ; ENSP00000315915 ; ENSG00000177721 .
    GeneIDi 389289.
    KEGGi hsa:389289.
    UCSCi uc003jnf.3. human.

    Organism-specific databases

    CTDi 389289.
    GeneCardsi GC05M043042.
    HGNCi HGNC:33463. ANXA2R.
    HPAi HPA051482.
    MIMi 611296. gene.
    neXtProti NX_Q3ZCQ2.
    PharmGKBi PA162380171.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG78262.
    HOGENOMi HOG000169180.
    InParanoidi Q3ZCQ2.
    OMAi LSSPCWR.
    OrthoDBi EOG7D85XK.
    PhylomeDBi Q3ZCQ2.
    TreeFami TF342039.

    Miscellaneous databases

    GenomeRNAii 389289.
    NextBioi 102755.
    PROi Q3ZCQ2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q3ZCQ2.
    CleanExi HS_C5orf39.
    Genevestigatori Q3ZCQ2.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of the annexin II receptor on human marrow stromal cells."
      Lu G., Maeda H., Reddy S.V., Kurihara N., Leach R., Anderson J.L., Roodman G.D.
      J. Biol. Chem. 281:30542-30550(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], POSSIBLE FUNCTION, TISSUE SPECIFICITY.
      Tissue: Bone marrow.
    2. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-119.
      Tissue: Placenta.
    4. "Annexin II increases osteoclast formation by stimulating the proliferation of osteoclast precursors in human marrow cultures."
      Menaa C., Devlin R.D., Reddy S.V., Gazitt Y., Choi S.J., Roodman G.D.
      J. Clin. Invest. 103:1605-1613(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiAX2R_HUMAN
    AccessioniPrimary (citable) accession number: Q3ZCQ2
    Secondary accession number(s): Q8NHX5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 24, 2007
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 62 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    PubMed:16895901 reports that it is a type I membrane protein. However, no clear transmembrane region is detected by prediction methods, suggesting that its localization at the plasma membrane is unsure.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3