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Q3ZCQ2 (AX2R_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Annexin-2 receptor
Alternative name(s):
Annexin II receptor
Short name=AXIIR
Gene names
Name:ANXA2R
Synonyms:AX2R, C5orf39
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length193 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May act as a receptor for annexin II on marrow stromal cells to induce osteoclast formation. Ref.1

Tissue specificity

Widely expressed. Highly expressed in lymphocytes. Expressed in both resting CD4+ and CD8+ T-cells. Ref.1

Caution

Ref.1 reports that it is a type I membrane protein. However, no clear transmembrane region is detected by prediction methods, suggesting that its localization at the plasma membrane is unsure.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   Molecular functionReceptor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 193193Annexin-2 receptor
PRO_0000295727

Natural variations

Natural variant1191Q → R. Ref.3
Corresponds to variant rs1054428 [ dbSNP | Ensembl ].
VAR_033348
Natural variant1861R → W.
Corresponds to variant rs10971 [ dbSNP | Ensembl ].
VAR_033349

Sequences

Sequence LengthMass (Da)Tools
Q3ZCQ2 [UniParc].

Last modified May 18, 2010. Version 2.
Checksum: 6BBC734AB14CE32F

FASTA19321,682
        10         20         30         40         50         60 
MEQHFLGCVK RAWDSAEVAP EPQPPPIVSS EDRGPWPLPL YPVLGEYSLD SCDLGLLSSP 

        70         80         90        100        110        120 
CWRLPGVYWQ NGLSPGVQST LEPSTAKPTE FSWPGTQKQQ EAPVEEVGQA EEPDRLRLQQ 

       130        140        150        160        170        180 
LPWSSPLHPW DRQQDTEVCD SGCLLERRHP PALQPWRHLP GFSDCLEWIL RVGFAAFSVL 

       190 
WACCSRICGA KQP 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of the annexin II receptor on human marrow stromal cells."
Lu G., Maeda H., Reddy S.V., Kurihara N., Leach R., Anderson J.L., Roodman G.D.
J. Biol. Chem. 281:30542-30550(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], POSSIBLE FUNCTION, TISSUE SPECIFICITY.
Tissue: Bone marrow.
[2]"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. expand/collapse author list , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-119.
Tissue: Placenta.
[4]"Annexin II increases osteoclast formation by stimulating the proliferation of osteoclast precursors in human marrow cultures."
Menaa C., Devlin R.D., Reddy S.V., Gazitt Y., Choi S.J., Roodman G.D.
J. Clin. Invest. 103:1605-1613(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY032883 mRNA. Translation: AAK52335.1.
AC025171 Genomic DNA. No translation available.
BC067873 mRNA. Translation: AAH67873.1.
RefSeqNP_001014301.1. NM_001014279.2.
UniGeneHs.529385.

3D structure databases

ProteinModelPortalQ3ZCQ2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid133074. 1 interaction.
STRING9606.ENSP00000315915.

Proteomic databases

PRIDEQ3ZCQ2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000314890; ENSP00000315915; ENSG00000177721.
GeneID389289.
KEGGhsa:389289.
UCSCuc003jnf.3. human.

Organism-specific databases

CTD389289.
GeneCardsGC05M043042.
HGNCHGNC:33463. ANXA2R.
HPAHPA051482.
MIM611296. gene.
neXtProtNX_Q3ZCQ2.
PharmGKBPA162380171.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG78262.
HOGENOMHOG000169180.
InParanoidQ3ZCQ2.
OMALSSPCWR.
OrthoDBEOG7D85XK.
PhylomeDBQ3ZCQ2.
TreeFamTF342039.

Gene expression databases

BgeeQ3ZCQ2.
CleanExHS_C5orf39.
GenevestigatorQ3ZCQ2.

Family and domain databases

ProtoNetSearch...

Other

GenomeRNAi389289.
NextBio102755.
PROQ3ZCQ2.
SOURCESearch...

Entry information

Entry nameAX2R_HUMAN
AccessionPrimary (citable) accession number: Q3ZCQ2
Secondary accession number(s): Q8NHX5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: May 18, 2010
Last modified: February 19, 2014
This is version 60 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM