Reviewed, UniProtKB/Swiss-Prot Q3ZCQ2 (AX2R_HUMAN)

Names and origin

Protein names

Recommended name:
    Annexin-2 receptor
Alternative name(s):
    Annexin-II receptor
      Short name=AXIIR

Gene names

Name:	AX2R
Synonyms:	C5orf39

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	193 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May act as a receptor for annexin II on marrow stromal cells to induce osteoclast formation. Ref.1
Tissue specificity	Widely expressed. Highly expressed in lymphocytes. Expressed in both resting CD4+ and CD8+ T-cells. Ref.1
Caution	Ref.1 reports that it is a type I membrane protein. However, no clear transmembrane region is detected by prediction methods, suggesting that its localization at the plasma membrane is unsure.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Molecular function	Receptor
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 193	193	Annexin-2 receptor		PRO_0000295727
Natural variations
	Natural variant	119	1	R → Q: dbSNP rs1054428. Ref.1		VAR_033348
	Natural variant	186	1	R → W: dbSNP rs10971.		VAR_033349

Sequences

	Sequence		Length	Mass (Da)
	Q3ZCQ2-1 [UniParc]. Last modified September 27, 2005. Version 1. Checksum: 6BBC70867E4F2FE0	FASTA	193	21,710
	10 20 30 40 50 60 MEQHFLGCVK RAWDSAEVAP EPQPPPIVSS EDRGPWPLPL YPVLGEYSLD SCDLGLLSSP 70 80 90 100 110 120 CWRLPGVYWQ NGLSPGVQST LEPSTAKPTE FSWPGTQKQQ EAPVEEVGQA EEPDRLRLRQ 130 140 150 160 170 180 LPWSSPLHPW DRQQDTEVCD SGCLLERRHP PALQPWRHLP GFSDCLEWIL RVGFAAFSVL 190 WACCSRICGA KQP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of the annexin II receptor on human marrow stromal cells." Lu G., Maeda H., Reddy S.V., Kurihara N., Leach R., Anderson J.L., Roodman G.D. J. Biol. Chem. 281:30542-30550(2006) [PubMed: 16895901] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], POSSIBLE FUNCTION, TISSUE SPECIFICITY, VARIANT GLN-119. Tissue: Bone marrow.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[3]	"Annexin II increases osteoclast formation by stimulating the proliferation of osteoclast precursors in human marrow cultures." Menaa C., Devlin R.D., Reddy S.V., Gazitt Y., Choi S.J., Roodman G.D. J. Clin. Invest. 103:1605-1613(1999) [PubMed: 10359570] [Abstract] Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY032883 mRNA. Translation: AAK52335.1. BC067873 mRNA. Translation: AAH67873.1.
IPI	IPI00169368.
RefSeq	NP_001014301.1.
UniGene	Hs.529385 Hs.700260
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q3ZCQ2.
Genome annotation databases
Ensembl	ENST00000314890; ENSP00000315915; ENSG00000177721; Homo sapiens. [Genome view]
GeneID	389289.
KEGG	hsa:389289.
UCSC	uc003jnf.1. human.
Organism-specific databases
CTD	389289.
GeneCards	GC05M043076.
HGNC	HGNC:33463. C5orf39.
MIM	611296. gene.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q3ZCQ2.
Gene expression databases
ArrayExpress	Q3ZCQ2.
Bgee	Q3ZCQ2.
CleanEx	HS_C5orf39.
Genevestigator	Q3ZCQ2.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	102755.
SOURCE	Search...

Entry information

Entry name

AX2R_HUMAN

Accession

Primary (citable) accession number: Q3ZCQ2
Secondary accession number(s): Q8NHX5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 24, 2007
Last sequence update:	September 27, 2005
Last modified:	October 13, 2009
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.