##gff-version 3
Q3ZCM7	UniProtKB	Chain	1	444	.	.	.	ID=PRO_0000320631;Note=Tubulin beta-8 chain	
Q3ZCM7	UniProtKB	Region	423	444	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
Q3ZCM7	UniProtKB	Motif	1	4	.	.	.	Note=MREI motif;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P07437	
Q3ZCM7	UniProtKB	Compositional bias	427	444	.	.	.	Note=Acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
Q3ZCM7	UniProtKB	Binding site	11	11	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13509	
Q3ZCM7	UniProtKB	Binding site	69	69	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P68363	
Q3ZCM7	UniProtKB	Binding site	69	69	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P68363	
Q3ZCM7	UniProtKB	Binding site	138	138	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13509	
Q3ZCM7	UniProtKB	Binding site	142	142	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13509	
Q3ZCM7	UniProtKB	Binding site	143	143	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13509	
Q3ZCM7	UniProtKB	Binding site	144	144	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13509	
Q3ZCM7	UniProtKB	Binding site	204	204	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13509	
Q3ZCM7	UniProtKB	Binding site	226	226	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13509	
Q3ZCM7	UniProtKB	Modified residue	172	172	.	.	.	Note=Phosphoserine%3B by CDK1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16371510;Dbxref=PMID:16371510	
Q3ZCM7	UniProtKB	Modified residue	436	436	.	.	.	Note=5-glutamyl polyglutamate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q2T9S0	
Q3ZCM7	UniProtKB	Natural variant	2	2	.	.	.	ID=VAR_076898;Note=In OZEMA2%3B loss of function in oocyte maturation%3B decreased alpha/beta-tubulin heterodimer assembly. R->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26789871;Dbxref=dbSNP:rs869025273,PMID:26789871	
Q3ZCM7	UniProtKB	Natural variant	27	33	.	.	.	ID=VAR_076899;Note=In OZEMA2%3B loss of alpha/beta-tubulin heterodimer assembly%3B loss of function in meiotic spindle assembly. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27273344;Dbxref=PMID:27273344	
Q3ZCM7	UniProtKB	Natural variant	54	54	.	.	.	ID=VAR_087566;Note=In OZEMA2%3B loss of function in meiotic spindle assembly and oocyte maturation%3B when expressed in mouse oocytes it leads to abnormal spindle structure and maturation arrest. A->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:32316999,ECO:0000269|PubMed:34509376;Dbxref=dbSNP:rs375210323,PMID:32316999,PMID:34509376	
Q3ZCM7	UniProtKB	Natural variant	176	176	.	.	.	ID=VAR_076900;Note=In OZEMA2%3B loss of function in oocyte maturation%3B loss of function in meiotic spindle assembly%3B decreased alpha/beta-tubulin heterodimer assembly. S->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:26789871,ECO:0000269|PubMed:27273344;Dbxref=dbSNP:rs869025609,PMID:26789871,PMID:27273344	
Q3ZCM7	UniProtKB	Natural variant	210	210	.	.	.	ID=VAR_076901;Note=In OZEMA2%3B decreased alpha/beta-tubulin heterodimer assembly%3B loss of function in meiotic spindle assembly. I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27273344;Dbxref=dbSNP:rs781853492,PMID:27273344	
Q3ZCM7	UniProtKB	Natural variant	229	229	.	.	.	ID=VAR_076902;Note=In OZEMA2%3B loss of function in oocyte maturation%3B decreased alpha/beta-tubulin heterodimer assembly. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26789871;Dbxref=dbSNP:rs869025271,PMID:26789871	
Q3ZCM7	UniProtKB	Natural variant	238	238	.	.	.	ID=VAR_076903;Note=In OZEMA2%3B decreased alpha/beta-tubulin heterodimer assembly%3B loss of function in meiotic spindle assembly. T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27273344;Dbxref=dbSNP:rs1057520306,PMID:27273344	
Q3ZCM7	UniProtKB	Natural variant	255	255	.	.	.	ID=VAR_076904;Note=In OZEMA2%3B loss of function in meiotic spindle assembly. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27273344;Dbxref=dbSNP:rs782269374,PMID:27273344	
Q3ZCM7	UniProtKB	Natural variant	262	262	.	.	.	ID=VAR_076905;Note=In OZEMA2%3B loss of function in oocyte maturation%3B decreased alpha/beta-tubulin heterodimer assembly. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26789871;Dbxref=dbSNP:rs869025610,PMID:26789871	
Q3ZCM7	UniProtKB	Natural variant	262	262	.	.	.	ID=VAR_076906;Note=In OZEMA2%3B decreased alpha/beta-tubulin heterodimer assembly%3B does not affect function in meiotic spindle assembly. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27273344;Dbxref=dbSNP:rs782486119,PMID:27273344	
Q3ZCM7	UniProtKB	Natural variant	285	285	.	.	.	ID=VAR_076907;Note=In OZEMA2%3B loss of function in meiotic spindle assembly. T->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27273344;Dbxref=PMID:27273344	
Q3ZCM7	UniProtKB	Natural variant	300	300	.	.	.	ID=VAR_076908;Note=In OZEMA2%3B loss of function in oocyte maturation%3B decreased alpha/beta-tubulin heterodimer assembly. M->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26789871;Dbxref=dbSNP:rs869025612,PMID:26789871	
Q3ZCM7	UniProtKB	Natural variant	320	320	.	.	.	ID=VAR_087567;Note=In OZEMA2%3B loss of function in meiotic spindle assembly and oocyte maturation%3B when expressed in mouse oocytes it leads to abnormal spindle structure and maturation arrest. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:34509376;Dbxref=dbSNP:rs1465781298,PMID:34509376	
Q3ZCM7	UniProtKB	Natural variant	345	345	.	.	.	ID=VAR_039240;Note=L->F;Dbxref=dbSNP:rs4880608	
Q3ZCM7	UniProtKB	Natural variant	348	348	.	.	.	ID=VAR_076909;Note=In OZEMA2%3B loss of function in meiotic spindle assembly. N->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27273344;Dbxref=dbSNP:rs1270068662,PMID:27273344	
Q3ZCM7	UniProtKB	Natural variant	363	363	.	.	.	ID=VAR_076910;Note=In OZEMA2%3B loss of function in oocyte maturation%3B decreased alpha/beta-tubulin heterodimer assembly. M->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26789871;Dbxref=dbSNP:rs869025611,PMID:26789871	
Q3ZCM7	UniProtKB	Natural variant	417	417	.	.	.	ID=VAR_076911;Note=In OZEMA2%3B loss of function in oocyte maturation%3B loss of function in meiotic spindle assembly%3B decreased alpha/beta-tubulin heterodimer assembly. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26789871;Dbxref=dbSNP:rs869025272,PMID:26789871