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Protein

Arfaptin-2

Gene

ARFIP2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Putative target protein of ADP-ribosylation factor. Involved in membrane ruffling (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-BTA-6811440 Retrograde transport at the Trans-Golgi-Network

Names & Taxonomyi

Protein namesi
Recommended name:
Arfaptin-2
Alternative name(s):
ADP-ribosylation factor-interacting protein 2
Gene namesi
Name:ARFIP2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 15

Organism-specific databases

VGNCiVGNC:26068 ARFIP2

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002460831 – 341Arfaptin-2Add BLAST341

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei72PhosphoserineBy similarity1
Modified residuei76PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ3ZCL5
PeptideAtlasiQ3ZCL5
PRIDEiQ3ZCL5

Expressioni

Gene expression databases

BgeeiENSBTAG00000003566

Interactioni

Subunit structurei

Interacts with RAC1 by binding directly to it. Specifically binds to GTP-bound ARF1 and ARF6, but binds to RAC1.GTP and RAC1.GDP with similar affinities (By similarity). Directly interacts with ARL1 GTP-bound form; this interaction leads to an increase in the amount of bound GTP at steady state level (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004638

Structurei

3D structure databases

ProteinModelPortaliQ3ZCL5
SMRiQ3ZCL5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini121 – 321AHPROSITE-ProRule annotationAdd BLAST201

Phylogenomic databases

eggNOGiKOG3876 Eukaryota
ENOG410YJUM LUCA
GeneTreeiENSGT00500000044828
HOGENOMiHOG000236308
HOVERGENiHBG050564
InParanoidiQ3ZCL5
KOiK20314
OMAiVRIEMAQ
OrthoDBiEOG091G0H30
TreeFamiTF314945

Family and domain databases

Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR010504 AH_dom
IPR030798 Arfaptin_fam
PANTHERiPTHR12141 PTHR12141, 1 hit
PfamiView protein in Pfam
PF06456 Arfaptin, 1 hit
SMARTiView protein in SMART
SM01015 Arfaptin, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
PROSITEiView protein in PROSITE
PS50870 AH, 1 hit

Sequencei

Sequence statusi: Complete.

Q3ZCL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDGILGKAA TMEIPIHGNG EAGQLPEDDG LEQDLQQVMV SGPNLNETSI
60 70 80 90 100
VSGGYGGSGD GLIPTGSGRH PSHSATPAGP GDEVARGIAG EKFDIVKKWG
110 120 130 140 150
INTYKCTKQL LSERFGRGSR TVDLELELQI ELLRETKRKY ESVLQLGRAL
160 170 180 190 200
TAHLYSLLQT QHALGDAFAD LSQKSPELQE EFGYNAETQK LLCKNGETLL
210 220 230 240 250
GAVNFFVSSI NTLVTKTMED TLMTVKQYEA ARLEYDAYRT DLEELSLGPR
260 270 280 290 300
DAGTRGRLES AQATFQAHRD KYEKLRGDVA IKLKFLEENK IKVMHKQLLL
310 320 330 340
FHNAVSAYFA GNQKQLEQTL QQFNIKLRPP GAEKPSWLEE Q
Length:341
Mass (Da):37,711
Last modified:September 27, 2005 - v1
Checksum:i04085CA06F349160
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT025433 mRNA Translation: ABF57389.1
BC102052 mRNA Translation: AAI02053.1
RefSeqiNP_001029649.1, NM_001034477.2
UniGeneiBt.49536

Genome annotation databases

EnsembliENSBTAT00000004638; ENSBTAP00000004638; ENSBTAG00000003566
GeneIDi514938
KEGGibta:514938

Similar proteinsi

Entry informationi

Entry nameiARFP2_BOVIN
AccessioniPrimary (citable) accession number: Q3ZCL5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: September 27, 2005
Last modified: March 28, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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