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Reviewed, UniProtKB/Swiss-Prot Q3ZCK3 (BPNT1_BOVIN)

Last modified June 16, 2009. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    3'(2'),5'-bisphosphate nucleotidase 1
    EC=3.1.3.7
Alternative name(s):
    Bisphosphate 3'-nucleotidase 1
Gene names
Name: BPNT1
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

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Protein attributes

Sequence length308 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Has 1000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2) and inositol 1,3,4-trisphosphate (Ins(1,3,4)P3), but does not hydrolyze Ins1P, Ins(3,4)P2, Ins(1,3,4,5)P4 or InsP6 By similarity.

Catalytic activity

Adenosine 3',5'-bisphosphate + H2O = adenosine 5'-phosphate + phosphate.

Cofactor

Magnesium By similarity.

Enzyme regulation

Uncompetitive inhibition by micromolar concentrations of lithium. Competitive inhibition by inositol 1,4-bisphosphate By similarity.

Sequence similarities

Belongs to the inositol monophosphatase family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 3083073'(2'),5'-bisphosphate nucleotidase 1
PRO_0000282934

Regions

Region195 – 1984Substrate binding By similarity

Sites

Metal binding741Magnesium 1 By similarity
Metal binding1171Magnesium 1 By similarity
Metal binding1171Magnesium 2 By similarity
Metal binding1191Magnesium 1; via carbonyl oxygen By similarity
Metal binding1201Magnesium 2 By similarity
Metal binding2471Magnesium 2 By similarity

Amino acid modifications

Modified residue21N-acetylalanine By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q3ZCK3-1 [UniParc].

Last modified September 27, 2005. Version 1.
Checksum: 8A9184010B4B893C

FASTA30833,328
        10         20         30         40         50         60 
MASSPTVLMR LVASAYSIAQ KAGTIVRRVI AEGDLGIIEK TCATDLQTKA DRLVQVSICS 

        70         80         90        100        110        120 
SLARKFPKLT IIGEEDLPPE DVDQELIEDG QWEEILKQPC PSQYSAIKEE DLVVWVDPLD 

       130        140        150        160        170        180 
GTKEYTEGLL DNVTVLIGIA YEGKAIAGVI NQPYYNYQAG PDAVLGRTIW GVLGLGAFGF 

       190        200        210        220        230        240 
QLKEAPAGKH IITTTRSHNS QLVTDCITAM NPDDVLRVGG AGNKIIQLIE GKASAYVFAS 

       250        260        270        280        290        300 
PGCKKWDTCA PEVILHAVGG KLTDIHGNAL QYNKEVKHMN SAGVLATLRN YDYYASRVPQ 


SVKNALVP

« Hide

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References

[1]"Characterization of 954 bovine full-CDS cDNA sequences."
Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.
BMC Genomics 6:166-166(2005) [PubMed: 16305752] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Ileum.

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Cross-references

Sequence databases

BT030746 mRNA. Translation: ABS45062.1.
BC102110 mRNA. Translation: AAI02111.1.
IPIIPI00687550.
RefSeqNP_001029711.1.
UniGeneBt.49571

3D structure databases

SMRQ3ZCK3. Positions 7-308.
ModBaseSearch...

Genome annotation databases

EnsemblENSBTAG00000004064. Bos taurus. [Contig view]
GeneID521254.
KEGGbta:521254.

Phylogenomic databases

HOVERGENQ3ZCK3.
OMAQ3ZCK3. GFQLKEA.

Enzyme and pathway databases

BRENDA3.1.3.7. 251.

Family and domain databases

InterProIPR000760. Inositol_P.
[Graphical view]
PANTHERPTHR20854. Inositol_P. 1 hit.
PfamPF00459. Inositol_P. 1 hit.
[Graphical view]
PRINTSPR00378. INOSPHPHTASE.
PROSITEPS00629. IMP_1. 1 hit.
PS00630. IMP_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameBPNT1_BOVIN
AccessionPrimary (citable) accession number: Q3ZCK3
Secondary accession number(s): A7E3X5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: September 27, 2005
Last modified: June 16, 2009
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents