Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q3ZCJ8

- CATC_BOVIN

UniProt

Q3ZCJ8 - CATC_BOVIN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Dipeptidyl peptidase 1

Gene

CTSC

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Thiol protease. Has dipeptidylpeptidase activity. Can act as both an exopeptidase and endopeptidase. Can degrade glucagon. Plays a role in the generation of cytotoxic lymphocyte effector function By similarity.By similarity

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, except when Xaa is Arg or Lys, or Yaa or Zaa is Pro.

Cofactori

Binds 1 chloride ion per heavy chain.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei258 – 2581By similarity
Binding sitei302 – 3021ChlorideBy similarity
Binding sitei304 – 3041Chloride; via amide nitrogenBy similarity
Binding sitei347 – 3471ChlorideBy similarity
Active sitei405 – 4051By similarity
Active sitei427 – 4271By similarity

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW

GO - Biological processi

  1. zymogen activation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Ligandi

Chloride

Protein family/group databases

MEROPSiC01.070.

Names & Taxonomyi

Protein namesi
Recommended name:
Dipeptidyl peptidase 1 (EC:3.4.14.1)
Alternative name(s):
Cathepsin C
Cathepsin J
Dipeptidyl peptidase I
Short name:
DPP-I
Short name:
DPPI
Dipeptidyl transferase
Cleaved into the following 3 chains:
Alternative name(s):
Dipeptidyl peptidase I exclusion domain chain
Alternative name(s):
Dipeptidyl peptidase I heavy chain
Alternative name(s):
Dipeptidyl peptidase I light chain
Gene namesi
Name:CTSC
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Lysosome By similarity

GO - Cellular componenti

  1. lysosome Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424By similarityAdd
BLAST
Chaini25 – 134110Dipeptidyl peptidase 1 exclusion domain chainPRO_0000238121Add
BLAST
Propeptidei135 – 23096By similarityPRO_0000238122Add
BLAST
Chaini231 – 394164Dipeptidyl peptidase 1 heavy chainBy similarityPRO_0000238123Add
BLAST
Chaini395 – 46369Dipeptidyl peptidase 1 light chainBy similarityPRO_0000238124Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi29 – 291N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi30 ↔ 118By similarity
Glycosylationi53 – 531N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi54 ↔ 136By similarity
Glycosylationi144 – 1441N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi255 ↔ 298By similarity
Glycosylationi276 – 2761N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi291 ↔ 331By similarity
Disulfide bondi321 ↔ 337By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ3ZCJ8.
PRIDEiQ3ZCJ8.

Interactioni

Subunit structurei

Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000014735.

Structurei

3D structure databases

ProteinModelPortaliQ3ZCJ8.
SMRiQ3ZCJ8. Positions 25-463.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4870.
HOGENOMiHOG000068022.
HOVERGENiHBG005248.
InParanoidiQ3ZCJ8.
KOiK01275.

Family and domain databases

Gene3Di2.40.128.80. 1 hit.
InterProiIPR014882. CathepsinC_exc.
IPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF08773. CathepsinC_exc. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00645. Pept_C1. 1 hit.
[Graphical view]
SUPFAMiSSF75001. SSF75001. 1 hit.
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3ZCJ8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGPWSGSRLV ALLLLVYGAG SVRGDTPANC TYPDLLGTWV FQVGSSGSQR
60 70 80 90 100
DVNCSVMGPP EKKVVVHLKK LDTAYDDFGN SGHFTIIYNQ GFEIVLNDYK
110 120 130 140 150
WFAFFKYKEE GGKVTSYCHE TMTGWVHDVL GRNRACFTGR KTGNTSENVN
160 170 180 190 200
VNTARLAGLE ETYSNRLYRY NHDFVKAINA IQKSWTAAPY MEYETLTLKE
210 220 230 240 250
MIRRGGGHSR RIPRPKPAPI TAEIQKKILH LPTSWDWRNV HGINFVTPVR
260 270 280 290 300
NQGSCGSCYS FASMGMMEAR IRILTNNTQT PILSPQEVVS CSQYAQGCEG
310 320 330 340 350
GFPYLIAGKY AQDFGLVEED CFPYTGTDSP CRLKEGCFRY YSSEYHYVGG
360 370 380 390 400
FYGGCNEALM KLELVHQGPM AVAFEVYDDF LHYRKGVYHH TGLRDPFNPF
410 420 430 440 450
ELTNHAVLLV GYGTDAASGL DYWIVKNSWG TSWGENGYFR IRRGTDECAI
460
ESIALAATPI PKL
Length:463
Mass (Da):51,949
Last modified:September 27, 2005 - v1
Checksum:i5602557E041FB29C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC102115 mRNA. Translation: AAI02116.1.
RefSeqiNP_001028789.1. NM_001033617.2.
UniGeneiBt.49573.

Genome annotation databases

GeneIDi352958.
KEGGibta:352958.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC102115 mRNA. Translation: AAI02116.1 .
RefSeqi NP_001028789.1. NM_001033617.2.
UniGenei Bt.49573.

3D structure databases

ProteinModelPortali Q3ZCJ8.
SMRi Q3ZCJ8. Positions 25-463.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000014735.

Chemistry

BindingDBi Q3ZCJ8.
ChEMBLi CHEMBL1075050.

Protein family/group databases

MEROPSi C01.070.

Proteomic databases

PaxDbi Q3ZCJ8.
PRIDEi Q3ZCJ8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 352958.
KEGGi bta:352958.

Organism-specific databases

CTDi 1075.

Phylogenomic databases

eggNOGi COG4870.
HOGENOMi HOG000068022.
HOVERGENi HBG005248.
InParanoidi Q3ZCJ8.
KOi K01275.

Miscellaneous databases

NextBioi 20812686.

Family and domain databases

Gene3Di 2.40.128.80. 1 hit.
InterProi IPR014882. CathepsinC_exc.
IPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
[Graphical view ]
PANTHERi PTHR12411. PTHR12411. 1 hit.
Pfami PF08773. CathepsinC_exc. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view ]
PRINTSi PR00705. PAPAIN.
SMARTi SM00645. Pept_C1. 1 hit.
[Graphical view ]
SUPFAMi SSF75001. SSF75001. 1 hit.
PROSITEi PS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiCATC_BOVIN
AccessioniPrimary (citable) accession number: Q3ZCJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: September 27, 2005
Last modified: October 29, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3