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Q3ZCJ8 (CATC_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dipeptidyl peptidase 1
EC=3.4.14.1
Alternative name(s):
Cathepsin C
Cathepsin J
Dipeptidyl peptidase I
Short name=DPP-I
Short name=DPPI
Dipeptidyl transferase

Cleaved into the following 3 chains:

  1. Dipeptidyl peptidase 1 exclusion domain chain
    Alternative name(s):
    Dipeptidyl peptidase I exclusion domain chain
  2. Dipeptidyl peptidase 1 heavy chain
    Alternative name(s):
    Dipeptidyl peptidase I heavy chain
  3. Dipeptidyl peptidase 1 light chain
    Alternative name(s):
    Dipeptidyl peptidase I light chain
Gene names
Name:CTSC
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length463 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Thiol protease. Has dipeptidylpeptidase activity. Can act as both an exopeptidase and endopeptidase. Can degrade glucagon. Plays a role in the generation of cytotoxic lymphocyte effector function By similarity.

Catalytic activity

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, except when Xaa is Arg or Lys, or Yaa or Zaa is Pro.

Cofactor

Binds 1 chloride ion per heavy chain By similarity.

Subunit structure

Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains By similarity.

Subcellular location

Lysosome By similarity.

Sequence similarities

Belongs to the peptidase C1 family.

Ontologies

Keywords
   Cellular componentLysosome
   DomainSignal
   LigandChloride
   Molecular functionHydrolase
Protease
Thiol protease
   PTMDisulfide bond
Glycoprotein
Zymogen
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processproteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

zymogen activation

Inferred from direct assay PubMed 20435891. Source: UniProtKB

   Cellular_componentlysosome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncysteine-type peptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 By similarity
Chain25 – 134110Dipeptidyl peptidase 1 exclusion domain chain
PRO_0000238121
Propeptide135 – 23096 By similarity
PRO_0000238122
Chain231 – 394164Dipeptidyl peptidase 1 heavy chain By similarity
PRO_0000238123
Chain395 – 46369Dipeptidyl peptidase 1 light chain By similarity
PRO_0000238124

Sites

Active site2581 By similarity
Active site4051 By similarity
Active site4271 By similarity
Binding site3021Chloride By similarity
Binding site3041Chloride; via amide nitrogen By similarity
Binding site3471Chloride By similarity

Amino acid modifications

Glycosylation291N-linked (GlcNAc...) Potential
Glycosylation531N-linked (GlcNAc...) Potential
Glycosylation1441N-linked (GlcNAc...) Potential
Glycosylation2761N-linked (GlcNAc...) Potential
Disulfide bond30 ↔ 118 By similarity
Disulfide bond54 ↔ 136 By similarity
Disulfide bond255 ↔ 298 By similarity
Disulfide bond291 ↔ 331 By similarity
Disulfide bond321 ↔ 337 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3ZCJ8 [UniParc].

Last modified September 27, 2005. Version 1.
Checksum: 5602557E041FB29C

FASTA46351,949
        10         20         30         40         50         60 
MGPWSGSRLV ALLLLVYGAG SVRGDTPANC TYPDLLGTWV FQVGSSGSQR DVNCSVMGPP 

        70         80         90        100        110        120 
EKKVVVHLKK LDTAYDDFGN SGHFTIIYNQ GFEIVLNDYK WFAFFKYKEE GGKVTSYCHE 

       130        140        150        160        170        180 
TMTGWVHDVL GRNRACFTGR KTGNTSENVN VNTARLAGLE ETYSNRLYRY NHDFVKAINA 

       190        200        210        220        230        240 
IQKSWTAAPY MEYETLTLKE MIRRGGGHSR RIPRPKPAPI TAEIQKKILH LPTSWDWRNV 

       250        260        270        280        290        300 
HGINFVTPVR NQGSCGSCYS FASMGMMEAR IRILTNNTQT PILSPQEVVS CSQYAQGCEG 

       310        320        330        340        350        360 
GFPYLIAGKY AQDFGLVEED CFPYTGTDSP CRLKEGCFRY YSSEYHYVGG FYGGCNEALM 

       370        380        390        400        410        420 
KLELVHQGPM AVAFEVYDDF LHYRKGVYHH TGLRDPFNPF ELTNHAVLLV GYGTDAASGL 

       430        440        450        460 
DYWIVKNSWG TSWGENGYFR IRRGTDECAI ESIALAATPI PKL

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References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Ileum.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC102115 mRNA. Translation: AAI02116.1.
IPIIPI00697314.
RefSeqNP_001028789.1. NM_001033617.2.
UniGeneBt.49573.

3D structure databases

ProteinModelPortalQ3ZCJ8.
SMRQ3ZCJ8. Positions 25-463.
ModBaseSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000014735.

Proteomic databases

PaxDbQ3ZCJ8.
PRIDEQ3ZCJ8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID352958.
KEGGbta:352958.

Organism-specific databases

CTD1075.

Phylogenomic databases

eggNOGCOG4870.
HOGENOMHOG000068022.
HOVERGENHBG005248.
InParanoidQ3ZCJ8.
KOK01275.
OrthoDBEOG4H19VZ.

Family and domain databases

InterProIPR014882. CathepsinC_exc.
IPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
[Graphical view]
PANTHERPTHR12411. PTHR12411. 1 hit.
PfamPF08773. CathepsinC_exc. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSPR00705. PAPAIN.
SMARTSM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

BindingDBQ3ZCJ8.
ChEMBLCHEMBL1075050.
NextBio20812686.

Entry information

Entry nameCATC_BOVIN
AccessionPrimary (citable) accession number: Q3ZCJ8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: September 27, 2005
Last modified: April 3, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

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