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Q3ZCJ8

- CATC_BOVIN

UniProt

Q3ZCJ8 - CATC_BOVIN

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Protein
Dipeptidyl peptidase 1
Gene
CTSC
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Thiol protease. Has dipeptidylpeptidase activity. Can act as both an exopeptidase and endopeptidase. Can degrade glucagon. Plays a role in the generation of cytotoxic lymphocyte effector function By similarity.

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, except when Xaa is Arg or Lys, or Yaa or Zaa is Pro.

Cofactori

Binds 1 chloride ion per heavy chain By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei258 – 2581 By similarity
Binding sitei302 – 3021Chloride By similarity
Binding sitei304 – 3041Chloride; via amide nitrogen By similarity
Binding sitei347 – 3471Chloride By similarity
Active sitei405 – 4051 By similarity
Active sitei427 – 4271 By similarity

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW

GO - Biological processi

  1. zymogen activation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Ligandi

Chloride

Protein family/group databases

MEROPSiC01.070.

Names & Taxonomyi

Protein namesi
Recommended name:
Dipeptidyl peptidase 1 (EC:3.4.14.1)
Alternative name(s):
Cathepsin C
Cathepsin J
Dipeptidyl peptidase I
Short name:
DPP-I
Short name:
DPPI
Dipeptidyl transferase
Cleaved into the following 3 chains:
Alternative name(s):
Dipeptidyl peptidase I exclusion domain chain
Alternative name(s):
Dipeptidyl peptidase I heavy chain
Alternative name(s):
Dipeptidyl peptidase I light chain
Gene namesi
Name:CTSC
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Lysosome By similarity

GO - Cellular componenti

  1. lysosome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 By similarity
Add
BLAST
Chaini25 – 134110Dipeptidyl peptidase 1 exclusion domain chain
PRO_0000238121Add
BLAST
Propeptidei135 – 23096 By similarity
PRO_0000238122Add
BLAST
Chaini231 – 394164Dipeptidyl peptidase 1 heavy chain By similarity
PRO_0000238123Add
BLAST
Chaini395 – 46369Dipeptidyl peptidase 1 light chain By similarity
PRO_0000238124Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi29 – 291N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi30 ↔ 118 By similarity
Glycosylationi53 – 531N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi54 ↔ 136 By similarity
Glycosylationi144 – 1441N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi255 ↔ 298 By similarity
Glycosylationi276 – 2761N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi291 ↔ 331 By similarity
Disulfide bondi321 ↔ 337 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ3ZCJ8.
PRIDEiQ3ZCJ8.

Interactioni

Subunit structurei

Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains By similarity.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000014735.

Structurei

3D structure databases

ProteinModelPortaliQ3ZCJ8.
SMRiQ3ZCJ8. Positions 25-463.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4870.
HOGENOMiHOG000068022.
HOVERGENiHBG005248.
InParanoidiQ3ZCJ8.
KOiK01275.

Family and domain databases

Gene3Di2.40.128.80. 1 hit.
InterProiIPR014882. CathepsinC_exc.
IPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF08773. CathepsinC_exc. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00645. Pept_C1. 1 hit.
[Graphical view]
SUPFAMiSSF75001. SSF75001. 1 hit.
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3ZCJ8-1 [UniParc]FASTAAdd to Basket

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MGPWSGSRLV ALLLLVYGAG SVRGDTPANC TYPDLLGTWV FQVGSSGSQR    50
DVNCSVMGPP EKKVVVHLKK LDTAYDDFGN SGHFTIIYNQ GFEIVLNDYK 100
WFAFFKYKEE GGKVTSYCHE TMTGWVHDVL GRNRACFTGR KTGNTSENVN 150
VNTARLAGLE ETYSNRLYRY NHDFVKAINA IQKSWTAAPY MEYETLTLKE 200
MIRRGGGHSR RIPRPKPAPI TAEIQKKILH LPTSWDWRNV HGINFVTPVR 250
NQGSCGSCYS FASMGMMEAR IRILTNNTQT PILSPQEVVS CSQYAQGCEG 300
GFPYLIAGKY AQDFGLVEED CFPYTGTDSP CRLKEGCFRY YSSEYHYVGG 350
FYGGCNEALM KLELVHQGPM AVAFEVYDDF LHYRKGVYHH TGLRDPFNPF 400
ELTNHAVLLV GYGTDAASGL DYWIVKNSWG TSWGENGYFR IRRGTDECAI 450
ESIALAATPI PKL 463
Length:463
Mass (Da):51,949
Last modified:September 27, 2005 - v1
Checksum:i5602557E041FB29C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC102115 mRNA. Translation: AAI02116.1.
RefSeqiNP_001028789.1. NM_001033617.2.
UniGeneiBt.49573.

Genome annotation databases

GeneIDi352958.
KEGGibta:352958.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC102115 mRNA. Translation: AAI02116.1 .
RefSeqi NP_001028789.1. NM_001033617.2.
UniGenei Bt.49573.

3D structure databases

ProteinModelPortali Q3ZCJ8.
SMRi Q3ZCJ8. Positions 25-463.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000014735.

Chemistry

BindingDBi Q3ZCJ8.
ChEMBLi CHEMBL1075050.

Protein family/group databases

MEROPSi C01.070.

Proteomic databases

PaxDbi Q3ZCJ8.
PRIDEi Q3ZCJ8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 352958.
KEGGi bta:352958.

Organism-specific databases

CTDi 1075.

Phylogenomic databases

eggNOGi COG4870.
HOGENOMi HOG000068022.
HOVERGENi HBG005248.
InParanoidi Q3ZCJ8.
KOi K01275.

Miscellaneous databases

NextBioi 20812686.

Family and domain databases

Gene3Di 2.40.128.80. 1 hit.
InterProi IPR014882. CathepsinC_exc.
IPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
[Graphical view ]
PANTHERi PTHR12411. PTHR12411. 1 hit.
Pfami PF08773. CathepsinC_exc. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view ]
PRINTSi PR00705. PAPAIN.
SMARTi SM00645. Pept_C1. 1 hit.
[Graphical view ]
SUPFAMi SSF75001. SSF75001. 1 hit.
PROSITEi PS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiCATC_BOVIN
AccessioniPrimary (citable) accession number: Q3ZCJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: September 27, 2005
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi