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Q3ZCJ8

- CATC_BOVIN

UniProt

Q3ZCJ8 - CATC_BOVIN

Protein

Dipeptidyl peptidase 1

Gene

CTSC

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (27 Sep 2005)
      Previous versions | rss
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    Functioni

    Thiol protease. Has dipeptidylpeptidase activity. Can act as both an exopeptidase and endopeptidase. Can degrade glucagon. Plays a role in the generation of cytotoxic lymphocyte effector function By similarity.By similarity

    Catalytic activityi

    Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, except when Xaa is Arg or Lys, or Yaa or Zaa is Pro.

    Cofactori

    Binds 1 chloride ion per heavy chain.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei258 – 2581By similarity
    Binding sitei302 – 3021ChlorideBy similarity
    Binding sitei304 – 3041Chloride; via amide nitrogenBy similarity
    Binding sitei347 – 3471ChlorideBy similarity
    Active sitei405 – 4051By similarity
    Active sitei427 – 4271By similarity

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW

    GO - Biological processi

    1. zymogen activation Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Ligandi

    Chloride

    Protein family/group databases

    MEROPSiC01.070.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dipeptidyl peptidase 1 (EC:3.4.14.1)
    Alternative name(s):
    Cathepsin C
    Cathepsin J
    Dipeptidyl peptidase I
    Short name:
    DPP-I
    Short name:
    DPPI
    Dipeptidyl transferase
    Cleaved into the following 3 chains:
    Alternative name(s):
    Dipeptidyl peptidase I exclusion domain chain
    Alternative name(s):
    Dipeptidyl peptidase I heavy chain
    Alternative name(s):
    Dipeptidyl peptidase I light chain
    Gene namesi
    Name:CTSC
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    Lysosome By similarity

    GO - Cellular componenti

    1. lysosome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Lysosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424By similarityAdd
    BLAST
    Chaini25 – 134110Dipeptidyl peptidase 1 exclusion domain chainPRO_0000238121Add
    BLAST
    Propeptidei135 – 23096By similarityPRO_0000238122Add
    BLAST
    Chaini231 – 394164Dipeptidyl peptidase 1 heavy chainBy similarityPRO_0000238123Add
    BLAST
    Chaini395 – 46369Dipeptidyl peptidase 1 light chainBy similarityPRO_0000238124Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi29 – 291N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi30 ↔ 118By similarity
    Glycosylationi53 – 531N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi54 ↔ 136By similarity
    Glycosylationi144 – 1441N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi255 ↔ 298By similarity
    Glycosylationi276 – 2761N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi291 ↔ 331By similarity
    Disulfide bondi321 ↔ 337By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    PaxDbiQ3ZCJ8.
    PRIDEiQ3ZCJ8.

    Interactioni

    Subunit structurei

    Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000014735.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3ZCJ8.
    SMRiQ3ZCJ8. Positions 25-463.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase C1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG4870.
    HOGENOMiHOG000068022.
    HOVERGENiHBG005248.
    InParanoidiQ3ZCJ8.
    KOiK01275.

    Family and domain databases

    Gene3Di2.40.128.80. 1 hit.
    InterProiIPR014882. CathepsinC_exc.
    IPR025661. Pept_asp_AS.
    IPR000169. Pept_cys_AS.
    IPR025660. Pept_his_AS.
    IPR013128. Peptidase_C1A.
    IPR000668. Peptidase_C1A_C.
    [Graphical view]
    PANTHERiPTHR12411. PTHR12411. 1 hit.
    PfamiPF08773. CathepsinC_exc. 1 hit.
    PF00112. Peptidase_C1. 1 hit.
    [Graphical view]
    PRINTSiPR00705. PAPAIN.
    SMARTiSM00645. Pept_C1. 1 hit.
    [Graphical view]
    SUPFAMiSSF75001. SSF75001. 1 hit.
    PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
    PS00139. THIOL_PROTEASE_CYS. 1 hit.
    PS00639. THIOL_PROTEASE_HIS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q3ZCJ8-1 [UniParc]FASTAAdd to Basket

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    MGPWSGSRLV ALLLLVYGAG SVRGDTPANC TYPDLLGTWV FQVGSSGSQR    50
    DVNCSVMGPP EKKVVVHLKK LDTAYDDFGN SGHFTIIYNQ GFEIVLNDYK 100
    WFAFFKYKEE GGKVTSYCHE TMTGWVHDVL GRNRACFTGR KTGNTSENVN 150
    VNTARLAGLE ETYSNRLYRY NHDFVKAINA IQKSWTAAPY MEYETLTLKE 200
    MIRRGGGHSR RIPRPKPAPI TAEIQKKILH LPTSWDWRNV HGINFVTPVR 250
    NQGSCGSCYS FASMGMMEAR IRILTNNTQT PILSPQEVVS CSQYAQGCEG 300
    GFPYLIAGKY AQDFGLVEED CFPYTGTDSP CRLKEGCFRY YSSEYHYVGG 350
    FYGGCNEALM KLELVHQGPM AVAFEVYDDF LHYRKGVYHH TGLRDPFNPF 400
    ELTNHAVLLV GYGTDAASGL DYWIVKNSWG TSWGENGYFR IRRGTDECAI 450
    ESIALAATPI PKL 463
    Length:463
    Mass (Da):51,949
    Last modified:September 27, 2005 - v1
    Checksum:i5602557E041FB29C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC102115 mRNA. Translation: AAI02116.1.
    RefSeqiNP_001028789.1. NM_001033617.2.
    UniGeneiBt.49573.

    Genome annotation databases

    GeneIDi352958.
    KEGGibta:352958.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC102115 mRNA. Translation: AAI02116.1 .
    RefSeqi NP_001028789.1. NM_001033617.2.
    UniGenei Bt.49573.

    3D structure databases

    ProteinModelPortali Q3ZCJ8.
    SMRi Q3ZCJ8. Positions 25-463.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000014735.

    Chemistry

    BindingDBi Q3ZCJ8.
    ChEMBLi CHEMBL1075050.

    Protein family/group databases

    MEROPSi C01.070.

    Proteomic databases

    PaxDbi Q3ZCJ8.
    PRIDEi Q3ZCJ8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 352958.
    KEGGi bta:352958.

    Organism-specific databases

    CTDi 1075.

    Phylogenomic databases

    eggNOGi COG4870.
    HOGENOMi HOG000068022.
    HOVERGENi HBG005248.
    InParanoidi Q3ZCJ8.
    KOi K01275.

    Miscellaneous databases

    NextBioi 20812686.

    Family and domain databases

    Gene3Di 2.40.128.80. 1 hit.
    InterProi IPR014882. CathepsinC_exc.
    IPR025661. Pept_asp_AS.
    IPR000169. Pept_cys_AS.
    IPR025660. Pept_his_AS.
    IPR013128. Peptidase_C1A.
    IPR000668. Peptidase_C1A_C.
    [Graphical view ]
    PANTHERi PTHR12411. PTHR12411. 1 hit.
    Pfami PF08773. CathepsinC_exc. 1 hit.
    PF00112. Peptidase_C1. 1 hit.
    [Graphical view ]
    PRINTSi PR00705. PAPAIN.
    SMARTi SM00645. Pept_C1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF75001. SSF75001. 1 hit.
    PROSITEi PS00640. THIOL_PROTEASE_ASN. 1 hit.
    PS00139. THIOL_PROTEASE_CYS. 1 hit.
    PS00639. THIOL_PROTEASE_HIS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Ileum.

    Entry informationi

    Entry nameiCATC_BOVIN
    AccessioniPrimary (citable) accession number: Q3ZCJ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: September 27, 2005
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3