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Q3ZCJ2

- AK1A1_BOVIN

UniProt

Q3ZCJ2 - AK1A1_BOVIN

Protein

Alcohol dehydrogenase [NADP(+)]

Gene

AKR1A1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (27 Sep 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs By similarity.By similarity

    Catalytic activityi

    An alcohol + NADP+ = an aldehyde + NADPH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei50 – 501Proton donor
    Sitei80 – 801Lowers pKa of active site TyrBy similarity
    Binding sitei113 – 1131SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi211 – 27363NADPBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. alcohol dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. L-glucuronate reductase activity Source: Ensembl

    GO - Biological processi

    1. aldehyde catabolic process Source: Ensembl
    2. D-glucuronate catabolic process Source: Ensembl
    3. L-ascorbic acid biosynthetic process Source: Ensembl

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    SABIO-RKQ3ZCJ2.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alcohol dehydrogenase [NADP(+)] (EC:1.1.1.2)
    Alternative name(s):
    Aldehyde reductase
    Aldo-keto reductase family 1 member A1
    Gene namesi
    Name:AKR1A1
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 3

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: Ensembl
    2. cytosol Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 325324Alcohol dehydrogenase [NADP(+)]PRO_0000287129Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei127 – 1271N6-acetyllysine; alternateBy similarity
    Modified residuei127 – 1271N6-succinyllysine; alternateBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiQ3ZCJ2.
    PRIDEiQ3ZCJ2.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000000630.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3ZCJ2.
    SMRiQ3ZCJ2. Positions 2-325.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldo/keto reductase family.Curated

    Phylogenomic databases

    eggNOGiCOG0656.
    GeneTreeiENSGT00750000117547.
    HOGENOMiHOG000250272.
    HOVERGENiHBG000020.
    InParanoidiQ3ZCJ2.
    KOiK00002.
    OMAiWPYAFER.
    OrthoDBiEOG70KGQF.
    TreeFamiTF106492.

    Family and domain databases

    Gene3Di3.20.20.100. 1 hit.
    InterProiIPR001395. Aldo/ket_red.
    IPR018170. Aldo/ket_reductase_CS.
    IPR020471. Aldo/keto_reductase_subgr.
    IPR023210. NADP_OxRdtase_dom.
    [Graphical view]
    PANTHERiPTHR11732. PTHR11732. 1 hit.
    PfamiPF00248. Aldo_ket_red. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000097. AKR. 1 hit.
    PRINTSiPR00069. ALDKETRDTASE.
    SUPFAMiSSF51430. SSF51430. 1 hit.
    PROSITEiPS00798. ALDOKETO_REDUCTASE_1. 1 hit.
    PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
    PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q3ZCJ2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAASCILLHT GQKMPLIGLG TWKSDPGQVK AAIKYALSVG YRHIDCAAIY    50
    GNETEIGEAL KENVGPGKLV PREELFVTSK LWNTKHHPED VEPALRKTLA 100
    DLQLEYLDLY LMHWPYAFER GDSPFPKNAD GTIRYDSTHY KETWRALEAL 150
    VAKGLVRALG LSNFNSRQID DVLSVASVRP AVLQVECHPY LAQNELIAHC 200
    QARNLEVTAY SPLGSSDRAW RDPEEPVLLK EPVVLALAEK HGRSPAQILL 250
    RWQVQRKVSC IPKSVTPSRI LENIQVFDFT FSPEEMKQLD ALNKNLRFIV 300
    PMLTVDGKRV PRDAGHPLYP FNDPY 325
    Length:325
    Mass (Da):36,617
    Last modified:September 27, 2005 - v1
    Checksum:i66584EFE75C03036
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC102166 mRNA. Translation: AAI02167.1.
    RefSeqiNP_001069981.1. NM_001076513.2.
    UniGeneiBt.49266.

    Genome annotation databases

    EnsembliENSBTAT00000000630; ENSBTAP00000000630; ENSBTAG00000000497.
    GeneIDi618607.
    KEGGibta:618607.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC102166 mRNA. Translation: AAI02167.1 .
    RefSeqi NP_001069981.1. NM_001076513.2.
    UniGenei Bt.49266.

    3D structure databases

    ProteinModelPortali Q3ZCJ2.
    SMRi Q3ZCJ2. Positions 2-325.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000000630.

    Proteomic databases

    PaxDbi Q3ZCJ2.
    PRIDEi Q3ZCJ2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000000630 ; ENSBTAP00000000630 ; ENSBTAG00000000497 .
    GeneIDi 618607.
    KEGGi bta:618607.

    Organism-specific databases

    CTDi 10327.

    Phylogenomic databases

    eggNOGi COG0656.
    GeneTreei ENSGT00750000117547.
    HOGENOMi HOG000250272.
    HOVERGENi HBG000020.
    InParanoidi Q3ZCJ2.
    KOi K00002.
    OMAi WPYAFER.
    OrthoDBi EOG70KGQF.
    TreeFami TF106492.

    Enzyme and pathway databases

    SABIO-RK Q3ZCJ2.

    Miscellaneous databases

    NextBioi 20901271.

    Family and domain databases

    Gene3Di 3.20.20.100. 1 hit.
    InterProi IPR001395. Aldo/ket_red.
    IPR018170. Aldo/ket_reductase_CS.
    IPR020471. Aldo/keto_reductase_subgr.
    IPR023210. NADP_OxRdtase_dom.
    [Graphical view ]
    PANTHERi PTHR11732. PTHR11732. 1 hit.
    Pfami PF00248. Aldo_ket_red. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000097. AKR. 1 hit.
    PRINTSi PR00069. ALDKETRDTASE.
    SUPFAMi SSF51430. SSF51430. 1 hit.
    PROSITEi PS00798. ALDOKETO_REDUCTASE_1. 1 hit.
    PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
    PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Ileum.

    Entry informationi

    Entry nameiAK1A1_BOVIN
    AccessioniPrimary (citable) accession number: Q3ZCJ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: September 27, 2005
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3