Reviewed,
UniProtKB/Swiss-Prot Q3ZCJ2 (AK1A1_BOVIN)
Last modified
November 3, 2009.
Version 34.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Alcohol dehydrogenase [NADP+] EC=1.1.1.2 Alternative name(s): Aldehyde reductase Aldo-keto reductase family 1 member A1 | ||
| Gene names |
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| Organism | Bos taurus (Bovine) | ||
| Taxonomic identifier | 9913 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Protein attributes
| Sequence length | 325 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs By similarity. |
| Catalytic activity | An alcohol + NADP+ = an aldehyde + NADPH. |
| Subunit structure | Monomer By similarity. |
| Sequence similarities | Belongs to the aldo/keto reductase family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | NADP |
| Molecular function | Oxidoreductase |
| PTM | Acetylation |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | alcohol dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed By similarity | ||||||
| Chain | 2 – 325 | 324 | Alcohol dehydrogenase [NADP+] | PRO_0000287129 | |||||
Regions | |||||||||
| Nucleotide binding | 211 – 273 | 63 | NADP By similarity | ||||||
Sites | |||||||||
| Active site | 50 | 1 | Proton donor | ||||||
| Binding site | 113 | 1 | Substrate By similarity | ||||||
| Site | 80 | 1 | Lowers pKa of active site Tyr By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 2 | 1 | N-acetylalanine By similarity | ||||||
Sequences
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References
| [1] | NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Ileum. |
Cross-references
Sequence databases | |
|---|---|
| BC102166 mRNA. Translation: AAI02167.1. | |
| IPI | IPI00686984. |
| RefSeq | NP_001069981.1. |
| UniGene | Bt.49266 |
3D structure databases | |
| SMR | Q3ZCJ2. Positions 2-325. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q3ZCJ2. |
Genome annotation databases | |
| Ensembl | ENSBTAT00000000630; ENSBTAP00000000630; ENSBTAG00000000497; Bos taurus. [Genome view] |
| GeneID | 618607. |
| KEGG | bta:618607. |
Organism-specific databases | |
| CTD | 618607. |
Phylogenomic databases | |
| HOVERGEN | Q3ZCJ2. |
| OMA | WRHPDEP. |
Enzyme and pathway databases | |
| BRENDA | 1.1.1.2. 251. |
Family and domain databases | |
| InterPro | IPR001395. Aldo/ket_red. IPR018170. Aldo/ket_reductase_CS. IPR020471. Aldo/keto_reductase_sg. [Graphical view] |
| Gene3D | G3DSA:3.20.20.100. Aldo/ket_red. 1 hit. |
| PANTHER | PTHR11732. Aldo/ket_red. 1 hit. |
| Pfam | PF00248. Aldo_ket_red. 1 hit. [Graphical view] |
| PRINTS | PR00069. ALDKETRDTASE. |
| ProDom | PD000288. Aldo/ket_red. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| PROSITE | PS00798. ALDOKETO_REDUCTASE_1. 1 hit. PS00062. ALDOKETO_REDUCTASE_2. 1 hit. PS00063. ALDOKETO_REDUCTASE_3. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | AK1A1_BOVIN | ||||||||
| Accession | Primary (citable) accession number: Q3ZCJ2 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||

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