Reviewed, UniProtKB/Swiss-Prot Q3ZCJ2 (AK1A1_BOVIN)

Names and origin

Protein names

Recommended name:
    Alcohol dehydrogenase [NADP+]
    EC=1.1.1.2
Alternative name(s):
    Aldehyde reductase
    Aldo-keto reductase family 1 member A1

Gene names

Name:

AKR1A1

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	325 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs By similarity.
Catalytic activity	An alcohol + NADP+ = an aldehyde + NADPH.
Subunit structure	Monomer By similarity.
Sequence similarities	Belongs to the aldo/keto reductase family.

Ontologies

Keywords
Ligand	NADP
Molecular function	Oxidoreductase
PTM	Acetylation
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	alcohol dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 325	324	Alcohol dehydrogenase [NADP+]		PRO_0000287129
Regions
	Nucleotide binding	211 – 273	63	NADP By similarity
Sites
	Active site	50	1	Proton donor
	Binding site	113	1	Substrate By similarity
	Site	80	1	Lowers pKa of active site Tyr By similarity
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3ZCJ2-1 [UniParc]. Last modified September 27, 2005. Version 1. Checksum: 66584EFE75C03036	FASTA	325	36,617
	10 20 30 40 50 60 MAASCILLHT GQKMPLIGLG TWKSDPGQVK AAIKYALSVG YRHIDCAAIY GNETEIGEAL 70 80 90 100 110 120 KENVGPGKLV PREELFVTSK LWNTKHHPED VEPALRKTLA DLQLEYLDLY LMHWPYAFER 130 140 150 160 170 180 GDSPFPKNAD GTIRYDSTHY KETWRALEAL VAKGLVRALG LSNFNSRQID DVLSVASVRP 190 200 210 220 230 240 AVLQVECHPY LAQNELIAHC QARNLEVTAY SPLGSSDRAW RDPEEPVLLK EPVVLALAEK 250 260 270 280 290 300 HGRSPAQILL RWQVQRKVSC IPKSVTPSRI LENIQVFDFT FSPEEMKQLD ALNKNLRFIV 310 320 PMLTVDGKRV PRDAGHPLYP FNDPY

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Ileum.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC102166 mRNA. Translation: AAI02167.1.
IPI	IPI00686984.
RefSeq	NP_001069981.1.
UniGene	Bt.49266
3D structure databases
SMR	Q3ZCJ2. Positions 2-325.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3ZCJ2.
Genome annotation databases
Ensembl	ENSBTAT00000000630; ENSBTAP00000000630; ENSBTAG00000000497; Bos taurus. [Genome view]
GeneID	618607.
KEGG	bta:618607.
Organism-specific databases
CTD	618607.
Phylogenomic databases
HOVERGEN	Q3ZCJ2.
OMA	WRHPDEP.
Enzyme and pathway databases
BRENDA	1.1.1.2. 251.
Family and domain databases
InterPro	IPR001395. Aldo/ket_red. IPR018170. Aldo/ket_reductase_CS. IPR020471. Aldo/keto_reductase_sg. [Graphical view]
Gene3D	G3DSA:3.20.20.100. Aldo/ket_red. 1 hit.
PANTHER	PTHR11732. Aldo/ket_red. 1 hit.
Pfam	PF00248. Aldo_ket_red. 1 hit. [Graphical view]
PRINTS	PR00069. ALDKETRDTASE.
ProDom	PD000288. Aldo/ket_red. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00798. ALDOKETO_REDUCTASE_1. 1 hit. PS00062. ALDOKETO_REDUCTASE_2. 1 hit. PS00063. ALDOKETO_REDUCTASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AK1A1_BOVIN

Accession

Primary (citable) accession number: Q3ZCJ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	September 27, 2005
Last modified:	November 3, 2009
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)