Q3ZCJ2 (AK1A1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alcohol dehydrogenase [NADP(+)]
EC=1.1.1.2

Alternative name(s):
Aldehyde reductase
Aldo-keto reductase family 1 member A1

Gene names

Name:

AKR1A1

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	325 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs By similarity.
Catalytic activity	An alcohol + NADP+ = an aldehyde + NADPH.
Subunit structure	Monomer By similarity.
Sequence similarities	Belongs to the aldo/keto reductase family.

Ontologies

Keywords
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	D-glucuronate catabolic process Inferred from electronic annotation. Source: Compara L-ascorbic acid biosynthetic process Inferred from electronic annotation. Source: Compara aldehyde catabolic process Inferred from electronic annotation. Source: Compara
Cellular_component	apical plasma membrane Inferred from electronic annotation. Source: Compara cytosol Inferred from electronic annotation. Source: Compara
Molecular_function	L-glucuronate reductase activity Inferred from electronic annotation. Source: Compara alcohol dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 325	324	Alcohol dehydrogenase [NADP(+)]		PRO_0000287129
Regions
	Nucleotide binding	211 – 273	63	NADP By similarity
Sites
	Active site	50	1	Proton donor
	Binding site	113	1	Substrate By similarity
	Site	80	1	Lowers pKa of active site Tyr By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3ZCJ2 [UniParc]. Last modified September 27, 2005. Version 1. Checksum: 66584EFE75C03036	FASTA	325	36,617
	10 20 30 40 50 60 MAASCILLHT GQKMPLIGLG TWKSDPGQVK AAIKYALSVG YRHIDCAAIY GNETEIGEAL 70 80 90 100 110 120 KENVGPGKLV PREELFVTSK LWNTKHHPED VEPALRKTLA DLQLEYLDLY LMHWPYAFER 130 140 150 160 170 180 GDSPFPKNAD GTIRYDSTHY KETWRALEAL VAKGLVRALG LSNFNSRQID DVLSVASVRP 190 200 210 220 230 240 AVLQVECHPY LAQNELIAHC QARNLEVTAY SPLGSSDRAW RDPEEPVLLK EPVVLALAEK 250 260 270 280 290 300 HGRSPAQILL RWQVQRKVSC IPKSVTPSRI LENIQVFDFT FSPEEMKQLD ALNKNLRFIV 310 320 PMLTVDGKRV PRDAGHPLYP FNDPY

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Ileum.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC102166 mRNA. Translation: AAI02167.1.
IPI	IPI00686984.
RefSeq	NP_001069981.1. NM_001076513.2.
UniGene	Bt.49266.
3D structure databases
ProteinModelPortal	Q3ZCJ2.
SMR	Q3ZCJ2. Positions 2-325.
ModBase	Search...
Protein-protein interaction databases
STRING	9913.ENSBTAP00000000630.
Proteomic databases
PaxDb	Q3ZCJ2.
PRIDE	Q3ZCJ2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000000630; ENSBTAP00000000630; ENSBTAG00000000497.
GeneID	618607.
KEGG	bta:618607.
Organism-specific databases
CTD	10327.
Phylogenomic databases
eggNOG	COG0656.
GeneTree	ENSGT00550000074107.
HOGENOM	HOG000250272.
HOVERGEN	HBG000020.
InParanoid	Q3ZCJ2.
KO	K00002.
OMA	ICYDSTH.
OrthoDB	EOG4J118N.
Enzyme and pathway databases
BioCyc	CATTLE:618607-MONOMER.
SABIO-RK	Q3ZCJ2.
Family and domain databases
Gene3D	3.20.20.100. 1 hit.
InterPro	IPR001395. Aldo/ket_red. IPR018170. Aldo/ket_reductase_CS. IPR020471. Aldo/keto_reductase_subgr. IPR023210. NADP_OxRdtase_dom. [Graphical view]
PANTHER	PTHR11732. PTHR11732. 1 hit.
Pfam	PF00248. Aldo_ket_red. 1 hit. [Graphical view]
PIRSF	PIRSF000097. AKR. 1 hit.
PRINTS	PR00069. ALDKETRDTASE.
SUPFAM	SSF51430. Aldo/ket_red. 1 hit.
PROSITE	PS00798. ALDOKETO_REDUCTASE_1. 1 hit. PS00062. ALDOKETO_REDUCTASE_2. 1 hit. PS00063. ALDOKETO_REDUCTASE_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20901271.

Entry information

Entry name

AK1A1_BOVIN

Accession

Primary (citable) accession number: Q3ZCJ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	September 27, 2005
Last modified:	May 29, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program