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Q3ZCJ2

- AK1A1_BOVIN

UniProt

Q3ZCJ2 - AK1A1_BOVIN

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Protein

Alcohol dehydrogenase [NADP(+)]

Gene
AKR1A1
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs By similarity.

Catalytic activityi

An alcohol + NADP+ = an aldehyde + NADPH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei50 – 501Proton donor
Sitei80 – 801Lowers pKa of active site Tyr By similarity
Binding sitei113 – 1131Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi211 – 27363NADP By similarityAdd
BLAST

GO - Molecular functioni

  1. alcohol dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. L-glucuronate reductase activity Source: Ensembl

GO - Biological processi

  1. aldehyde catabolic process Source: Ensembl
  2. D-glucuronate catabolic process Source: Ensembl
  3. L-ascorbic acid biosynthetic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Enzyme and pathway databases

SABIO-RKQ3ZCJ2.

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase [NADP(+)] (EC:1.1.1.2)
Alternative name(s):
Aldehyde reductase
Aldo-keto reductase family 1 member A1
Gene namesi
Name:AKR1A1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 3

Subcellular locationi

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. cytosol Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 325324Alcohol dehydrogenase [NADP(+)]PRO_0000287129Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity
Modified residuei127 – 1271N6-acetyllysine; alternate By similarity
Modified residuei127 – 1271N6-succinyllysine; alternate By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ3ZCJ2.
PRIDEiQ3ZCJ2.

Interactioni

Subunit structurei

Monomer By similarity.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000000630.

Structurei

3D structure databases

ProteinModelPortaliQ3ZCJ2.
SMRiQ3ZCJ2. Positions 2-325.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0656.
GeneTreeiENSGT00750000117547.
HOGENOMiHOG000250272.
HOVERGENiHBG000020.
InParanoidiQ3ZCJ2.
KOiK00002.
OMAiWPYAFER.
OrthoDBiEOG70KGQF.
TreeFamiTF106492.

Family and domain databases

Gene3Di3.20.20.100. 1 hit.
InterProiIPR001395. Aldo/ket_red.
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase_subgr.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERiPTHR11732. PTHR11732. 1 hit.
PfamiPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PIRSFiPIRSF000097. AKR. 1 hit.
PRINTSiPR00069. ALDKETRDTASE.
SUPFAMiSSF51430. SSF51430. 1 hit.
PROSITEiPS00798. ALDOKETO_REDUCTASE_1. 1 hit.
PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3ZCJ2-1 [UniParc]FASTAAdd to Basket

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MAASCILLHT GQKMPLIGLG TWKSDPGQVK AAIKYALSVG YRHIDCAAIY    50
GNETEIGEAL KENVGPGKLV PREELFVTSK LWNTKHHPED VEPALRKTLA 100
DLQLEYLDLY LMHWPYAFER GDSPFPKNAD GTIRYDSTHY KETWRALEAL 150
VAKGLVRALG LSNFNSRQID DVLSVASVRP AVLQVECHPY LAQNELIAHC 200
QARNLEVTAY SPLGSSDRAW RDPEEPVLLK EPVVLALAEK HGRSPAQILL 250
RWQVQRKVSC IPKSVTPSRI LENIQVFDFT FSPEEMKQLD ALNKNLRFIV 300
PMLTVDGKRV PRDAGHPLYP FNDPY 325
Length:325
Mass (Da):36,617
Last modified:September 27, 2005 - v1
Checksum:i66584EFE75C03036
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC102166 mRNA. Translation: AAI02167.1.
RefSeqiNP_001069981.1. NM_001076513.2.
UniGeneiBt.49266.

Genome annotation databases

EnsembliENSBTAT00000000630; ENSBTAP00000000630; ENSBTAG00000000497.
GeneIDi618607.
KEGGibta:618607.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC102166 mRNA. Translation: AAI02167.1 .
RefSeqi NP_001069981.1. NM_001076513.2.
UniGenei Bt.49266.

3D structure databases

ProteinModelPortali Q3ZCJ2.
SMRi Q3ZCJ2. Positions 2-325.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000000630.

Proteomic databases

PaxDbi Q3ZCJ2.
PRIDEi Q3ZCJ2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000000630 ; ENSBTAP00000000630 ; ENSBTAG00000000497 .
GeneIDi 618607.
KEGGi bta:618607.

Organism-specific databases

CTDi 10327.

Phylogenomic databases

eggNOGi COG0656.
GeneTreei ENSGT00750000117547.
HOGENOMi HOG000250272.
HOVERGENi HBG000020.
InParanoidi Q3ZCJ2.
KOi K00002.
OMAi WPYAFER.
OrthoDBi EOG70KGQF.
TreeFami TF106492.

Enzyme and pathway databases

SABIO-RK Q3ZCJ2.

Miscellaneous databases

NextBioi 20901271.

Family and domain databases

Gene3Di 3.20.20.100. 1 hit.
InterProi IPR001395. Aldo/ket_red.
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase_subgr.
IPR023210. NADP_OxRdtase_dom.
[Graphical view ]
PANTHERi PTHR11732. PTHR11732. 1 hit.
Pfami PF00248. Aldo_ket_red. 1 hit.
[Graphical view ]
PIRSFi PIRSF000097. AKR. 1 hit.
PRINTSi PR00069. ALDKETRDTASE.
SUPFAMi SSF51430. SSF51430. 1 hit.
PROSITEi PS00798. ALDOKETO_REDUCTASE_1. 1 hit.
PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiAK1A1_BOVIN
AccessioniPrimary (citable) accession number: Q3ZCJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: September 27, 2005
Last modified: April 16, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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