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Q3ZCJ2 (AK1A1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alcohol dehydrogenase [NADP(+)]

EC=1.1.1.2
Alternative name(s):
Aldehyde reductase
Aldo-keto reductase family 1 member A1
Gene names
Name:AKR1A1
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length325 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs By similarity.

Catalytic activity

An alcohol + NADP+ = an aldehyde + NADPH.

Subunit structure

Monomer By similarity.

Sequence similarities

Belongs to the aldo/keto reductase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 325324Alcohol dehydrogenase [NADP(+)]
PRO_0000287129

Regions

Nucleotide binding211 – 27363NADP By similarity

Sites

Active site501Proton donor
Binding site1131Substrate By similarity
Site801Lowers pKa of active site Tyr By similarity

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue1271N6-acetyllysine; alternate By similarity
Modified residue1271N6-succinyllysine; alternate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3ZCJ2 [UniParc].

Last modified September 27, 2005. Version 1.
Checksum: 66584EFE75C03036

FASTA32536,617
        10         20         30         40         50         60 
MAASCILLHT GQKMPLIGLG TWKSDPGQVK AAIKYALSVG YRHIDCAAIY GNETEIGEAL 

        70         80         90        100        110        120 
KENVGPGKLV PREELFVTSK LWNTKHHPED VEPALRKTLA DLQLEYLDLY LMHWPYAFER 

       130        140        150        160        170        180 
GDSPFPKNAD GTIRYDSTHY KETWRALEAL VAKGLVRALG LSNFNSRQID DVLSVASVRP 

       190        200        210        220        230        240 
AVLQVECHPY LAQNELIAHC QARNLEVTAY SPLGSSDRAW RDPEEPVLLK EPVVLALAEK 

       250        260        270        280        290        300 
HGRSPAQILL RWQVQRKVSC IPKSVTPSRI LENIQVFDFT FSPEEMKQLD ALNKNLRFIV 

       310        320 
PMLTVDGKRV PRDAGHPLYP FNDPY 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Ileum.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC102166 mRNA. Translation: AAI02167.1.
RefSeqNP_001069981.1. NM_001076513.2.
UniGeneBt.49266.

3D structure databases

ProteinModelPortalQ3ZCJ2.
SMRQ3ZCJ2. Positions 2-325.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000000630.

Proteomic databases

PaxDbQ3ZCJ2.
PRIDEQ3ZCJ2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000000630; ENSBTAP00000000630; ENSBTAG00000000497.
GeneID618607.
KEGGbta:618607.

Organism-specific databases

CTD10327.

Phylogenomic databases

eggNOGCOG0656.
GeneTreeENSGT00750000117547.
HOGENOMHOG000250272.
HOVERGENHBG000020.
InParanoidQ3ZCJ2.
KOK00002.
OMAWPYAFER.
OrthoDBEOG70KGQF.
TreeFamTF106492.

Enzyme and pathway databases

SABIO-RKQ3ZCJ2.

Family and domain databases

Gene3D3.20.20.100. 1 hit.
InterProIPR001395. Aldo/ket_red.
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase_subgr.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERPTHR11732. PTHR11732. 1 hit.
PfamPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PIRSFPIRSF000097. AKR. 1 hit.
PRINTSPR00069. ALDKETRDTASE.
SUPFAMSSF51430. SSF51430. 1 hit.
PROSITEPS00798. ALDOKETO_REDUCTASE_1. 1 hit.
PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20901271.

Entry information

Entry nameAK1A1_BOVIN
AccessionPrimary (citable) accession number: Q3ZCJ2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: September 27, 2005
Last modified: April 16, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families