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Protein

Stress-70 protein, mitochondrial

Gene

HSPA9

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Implicated in the control of cell proliferation and cellular aging. May also act as a chaperone (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Stress-70 protein, mitochondrial
Alternative name(s):
75 kDa glucose-regulated protein
Short name:
GRP-75
Heat shock 70 kDa protein 9
Gene namesi
Name:HSPA9
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4646MitochondrionBy similarityAdd
BLAST
Chaini47 – 679633Stress-70 protein, mitochondrialPRO_0000289950Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei76 – 761N6-acetyllysineBy similarity
Modified residuei87 – 871PhosphothreonineBy similarity
Modified residuei135 – 1351N6-acetyllysine; alternateBy similarity
Modified residuei135 – 1351N6-succinyllysine; alternateBy similarity
Modified residuei138 – 1381N6-acetyllysine; alternateBy similarity
Modified residuei138 – 1381N6-succinyllysine; alternateBy similarity
Modified residuei143 – 1431N6-acetyllysineBy similarity
Modified residuei206 – 2061N6-acetyllysine; alternateBy similarity
Modified residuei206 – 2061N6-malonyllysine; alternateBy similarity
Modified residuei206 – 2061N6-succinyllysine; alternateBy similarity
Modified residuei234 – 2341N6-acetyllysineBy similarity
Modified residuei288 – 2881N6-acetyllysineBy similarity
Modified residuei300 – 3001N6-acetyllysine; alternateBy similarity
Modified residuei300 – 3001N6-succinyllysine; alternateBy similarity
Modified residuei368 – 3681N6-succinyllysineBy similarity
Modified residuei394 – 3941N6-succinyllysineBy similarity
Modified residuei408 – 4081PhosphoserineBy similarity
Modified residuei567 – 5671N6-acetyllysine; alternateBy similarity
Modified residuei567 – 5671N6-succinyllysine; alternateBy similarity
Modified residuei600 – 6001N6-acetyllysine; alternateBy similarity
Modified residuei600 – 6001N6-succinyllysine; alternateBy similarity
Modified residuei610 – 6101N6-succinyllysineBy similarity
Modified residuei612 – 6121N6-acetyllysineBy similarity
Modified residuei646 – 6461N6-acetyllysine; alternateBy similarity
Modified residuei646 – 6461N6-succinyllysine; alternateBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ3ZCH0.
PeptideAtlasiQ3ZCH0.
PRIDEiQ3ZCH0.

Expressioni

Gene expression databases

BgeeiENSBTAG00000011419.

Interactioni

Subunit structurei

Interacts with FXN. Interacts with HSCB (By similarity). Associates with the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MINOS1/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1, MTX2 and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9. Interacts with DNLZ, the interaction is required to prevent self-aggregation (By similarity). Interacts with TESPA1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000015172.

Structurei

3D structure databases

ProteinModelPortaliQ3ZCH0.
SMRiQ3ZCH0. Positions 55-580.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0102. Eukaryota.
COG0443. LUCA.
GeneTreeiENSGT00820000127001.
HOGENOMiHOG000228135.
HOVERGENiHBG051845.
InParanoidiQ3ZCH0.
KOiK04043.
OMAiEKMAPPQ.
OrthoDBiEOG091G0386.
TreeFamiTF105046.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00332. DnaK. 1 hit.
InterProiIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
TIGRFAMsiTIGR02350. prok_dnaK. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3ZCH0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISASRAAVS RFVGTAASRG PTAARHQDGW NGLSHEAFRI VSRRDYASEA
60 70 80 90 100
IKGAVVGIDL GTTNSCVAVM EGKQAKVLEN AEGARTTPSV VAFTADGERL
110 120 130 140 150
VGMPAKRQAV TNPNNTFYAT KRLIGRRYDD PEVQKDIKNV PFKIVRASNG
160 170 180 190 200
DAWVEAHGKL YSPSQIGAFV LMKMKETAEN YLGHTAKNAV ITVPAYFNDS
210 220 230 240 250
QRQATKDAGQ ISGLNVLRVI NEPTAAALAY GLDKSEDKII AVYDLGGGTF
260 270 280 290 300
DISILEIQKG VFEVKSTNGD TFLGGEDFDQ ALLRHIVKEF KRETGVDLTK
310 320 330 340 350
DNMALQRVRE AAEKAKCELS SSVQTDINLP YLTMDASGPK HLNMKLTRAQ
360 370 380 390 400
FEGIVTDLIR RTIAPCQKAM QDAEVSKSDI GEVILVGGMT RMPKVQQTVQ
410 420 430 440 450
DLFGRAPSKA VNPDEAVAIG AAIQGGVLAG DVTDVLLLDV TPLSLGIETL
460 470 480 490 500
GGVFTKLINR NTTIPTKKSQ VFSTAADGQT QVEIKVCQGE REMAGDNKLL
510 520 530 540 550
GQFTLIGIPP APRGVPQIEV TFDIDANGIV HVSAKDKGTG REQQIVIQSS
560 570 580 590 600
GGLSKDDIEN MVKNAEKYAE EDRRKKERVE AVNMAEGIIH DTETKMEEFK
610 620 630 640 650
DQLPADECNK LKEEISKMRE LLARKDSETG ENIRQAASSL QQASLKLFEM
660 670
AYKKMASERE GSGSSGTGEQ KDNQKEEKQ
Length:679
Mass (Da):73,742
Last modified:September 27, 2005 - v1
Checksum:iC71EB246E9CED09B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT030525 mRNA. Translation: ABQ12965.1.
BC102334 mRNA. Translation: AAI02335.1.
RefSeqiNP_001029696.1. NM_001034524.2.
UniGeneiBt.35339.

Genome annotation databases

EnsembliENSBTAT00000015172; ENSBTAP00000015172; ENSBTAG00000011419.
GeneIDi517535.
KEGGibta:517535.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT030525 mRNA. Translation: ABQ12965.1.
BC102334 mRNA. Translation: AAI02335.1.
RefSeqiNP_001029696.1. NM_001034524.2.
UniGeneiBt.35339.

3D structure databases

ProteinModelPortaliQ3ZCH0.
SMRiQ3ZCH0. Positions 55-580.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000015172.

Proteomic databases

PaxDbiQ3ZCH0.
PeptideAtlasiQ3ZCH0.
PRIDEiQ3ZCH0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000015172; ENSBTAP00000015172; ENSBTAG00000011419.
GeneIDi517535.
KEGGibta:517535.

Organism-specific databases

CTDi3313.

Phylogenomic databases

eggNOGiKOG0102. Eukaryota.
COG0443. LUCA.
GeneTreeiENSGT00820000127001.
HOGENOMiHOG000228135.
HOVERGENiHBG051845.
InParanoidiQ3ZCH0.
KOiK04043.
OMAiEKMAPPQ.
OrthoDBiEOG091G0386.
TreeFamiTF105046.

Miscellaneous databases

PROiQ3ZCH0.

Gene expression databases

BgeeiENSBTAG00000011419.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00332. DnaK. 1 hit.
InterProiIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
TIGRFAMsiTIGR02350. prok_dnaK. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGRP75_BOVIN
AccessioniPrimary (citable) accession number: Q3ZCH0
Secondary accession number(s): A5D9A6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: September 27, 2005
Last modified: September 7, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.