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Protein

Ornithine aminotransferase, mitochondrial

Gene

OAT

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid.

Cofactori

Pathwayi: L-proline biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-glutamate 5-semialdehyde from L-ornithine.
Proteins known to be involved in this subpathway in this organism are:
  1. Ornithine aminotransferase, mitochondrial (OAT)
This subpathway is part of the pathway L-proline biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate 5-semialdehyde from L-ornithine, the pathway L-proline biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00098; UER00358.

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine aminotransferase, mitochondrial (EC:2.6.1.13)
Alternative name(s):
Ornithine--oxo-acid aminotransferase
Gene namesi
Name:OAT
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 25MitochondrionBy similarityAdd BLAST25
ChainiPRO_000028304326 – 439Ornithine aminotransferase, mitochondrialAdd BLAST414

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei49N6-acetyllysineBy similarity1
Modified residuei66N6-acetyllysineBy similarity1
Modified residuei102N6-succinyllysineBy similarity1
Modified residuei107N6-acetyllysine; alternateBy similarity1
Modified residuei107N6-succinyllysine; alternateBy similarity1
Modified residuei292N6-(pyridoxal phosphate)lysineBy similarity1
Modified residuei362N6-acetyllysine; alternateBy similarity1
Modified residuei362N6-succinyllysine; alternateBy similarity1
Modified residuei386N6-acetyllysineBy similarity1
Modified residuei392N6-acetyllysineBy similarity1
Modified residuei405N6-acetyllysine; alternateBy similarity1
Modified residuei405N6-succinyllysine; alternateBy similarity1
Modified residuei421N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ3ZCF5.
PeptideAtlasiQ3ZCF5.
PRIDEiQ3ZCF5.

Interactioni

Subunit structurei

Homohexamer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000009097.

Structurei

3D structure databases

ProteinModelPortaliQ3ZCF5.
SMRiQ3ZCF5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1402. Eukaryota.
COG4992. LUCA.
HOGENOMiHOG000020206.
HOVERGENiHBG000434.
InParanoidiQ3ZCF5.
KOiK00819.

Family and domain databases

CDDicd00610. OAT_like. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
InterProiView protein in InterPro
IPR005814. Aminotrans_3.
IPR010164. Orn_aminotrans.
IPR034758. Orn_aminotrans_mito.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_sub2.
PANTHERiPTHR11986:SF18. PTHR11986:SF18. 1 hit.
PfamiView protein in Pfam
PF00202. Aminotran_3. 1 hit.
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01885. Orn_aminotrans. 1 hit.
PROSITEiView protein in PROSITE
PS00600. AA_TRANSFER_CLASS_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3ZCF5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSKLARLQT VAGLGLGVHS SVASATSVAT KKTVQGPPSS DYIFERESKY
60 70 80 90 100
GAHNYHPLPV ALERGKGIYV WDVEGRKYFD FLSAYSAVNQ GHCHPKIVDA
110 120 130 140 150
LKSQVDKLTL TSRAFYNNVL GEYEEYVTKL FNYHKVLPMN TGVEAGETAC
160 170 180 190 200
KLARKWGYTV KGIPKYKAKI VFAAGNFWGR TLSAISSSTD PTSYDGFGPF
210 220 230 240 250
MPGFEIIPYN DLPALERALQ DPNVAAFMVE PIQGEAGVVV PDPGYLVGVR
260 270 280 290 300
ELCTQHQVLF IADEIQTGLA RTGRWLAIDH ENVRPDIVLL GKALSGGLYP
310 320 330 340 350
VSAVLCDDEI MLTIKPGEHG STYGGNPLGC RVAIAALEVL EEENLAENAE
360 370 380 390 400
KMGIILRNEL MKLPSDVVTT VRGKGLLNAI VIRETKDCDA WKVCLRLRDN
410 420 430
GLLAKPTHGD IIRFAPPLVI KEDEILEAVE IINKTILSF
Length:439
Mass (Da):48,075
Last modified:September 27, 2005 - v1
Checksum:i3A620B0CCDE3779E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102427 mRNA. Translation: AAI02428.1.
RefSeqiNP_001029412.1. NM_001034240.1.
UniGeneiBt.49448.

Genome annotation databases

GeneIDi505323.
KEGGibta:505323.

Similar proteinsi

Entry informationi

Entry nameiOAT_BOVIN
AccessioniPrimary (citable) accession number: Q3ZCF5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: September 27, 2005
Last modified: October 25, 2017
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families