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Protein

Ornithine aminotransferase, mitochondrial

Gene

OAT

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid.

Cofactori

Pathwayi: L-proline biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-glutamate 5-semialdehyde from L-ornithine.
Proteins known to be involved in this subpathway in this organism are:
  1. Ornithine aminotransferase, mitochondrial (OAT)
This subpathway is part of the pathway L-proline biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate 5-semialdehyde from L-ornithine, the pathway L-proline biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00098; UER00358.

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine aminotransferase, mitochondrial (EC:2.6.1.13)
Alternative name(s):
Ornithine--oxo-acid aminotransferase
Gene namesi
Name:OAT
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

  • Mitochondrion matrix By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2525MitochondrionBy similarityAdd
BLAST
Chaini26 – 439414Ornithine aminotransferase, mitochondrialPRO_0000283043Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei49 – 491N6-acetyllysineBy similarity
Modified residuei66 – 661N6-acetyllysineBy similarity
Modified residuei102 – 1021N6-succinyllysineBy similarity
Modified residuei107 – 1071N6-acetyllysine; alternateBy similarity
Modified residuei107 – 1071N6-succinyllysine; alternateBy similarity
Modified residuei292 – 2921N6-(pyridoxal phosphate)lysineBy similarity
Modified residuei362 – 3621N6-acetyllysine; alternateBy similarity
Modified residuei362 – 3621N6-succinyllysine; alternateBy similarity
Modified residuei386 – 3861N6-acetyllysineBy similarity
Modified residuei392 – 3921N6-acetyllysineBy similarity
Modified residuei405 – 4051N6-acetyllysine; alternateBy similarity
Modified residuei405 – 4051N6-succinyllysine; alternateBy similarity
Modified residuei421 – 4211N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ3ZCF5.
PRIDEiQ3ZCF5.

Interactioni

Subunit structurei

Homohexamer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000009097.

Structurei

3D structure databases

ProteinModelPortaliQ3ZCF5.
SMRiQ3ZCF5. Positions 36-439.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1402. Eukaryota.
COG4992. LUCA.
HOGENOMiHOG000020206.
HOVERGENiHBG000434.
InParanoidiQ3ZCF5.
KOiK00819.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
InterProiIPR005814. Aminotrans_3.
IPR010164. Orn_aminotrans.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PTHR11986:SF18. PTHR11986:SF18. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01885. Orn_aminotrans. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3ZCF5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSKLARLQT VAGLGLGVHS SVASATSVAT KKTVQGPPSS DYIFERESKY
60 70 80 90 100
GAHNYHPLPV ALERGKGIYV WDVEGRKYFD FLSAYSAVNQ GHCHPKIVDA
110 120 130 140 150
LKSQVDKLTL TSRAFYNNVL GEYEEYVTKL FNYHKVLPMN TGVEAGETAC
160 170 180 190 200
KLARKWGYTV KGIPKYKAKI VFAAGNFWGR TLSAISSSTD PTSYDGFGPF
210 220 230 240 250
MPGFEIIPYN DLPALERALQ DPNVAAFMVE PIQGEAGVVV PDPGYLVGVR
260 270 280 290 300
ELCTQHQVLF IADEIQTGLA RTGRWLAIDH ENVRPDIVLL GKALSGGLYP
310 320 330 340 350
VSAVLCDDEI MLTIKPGEHG STYGGNPLGC RVAIAALEVL EEENLAENAE
360 370 380 390 400
KMGIILRNEL MKLPSDVVTT VRGKGLLNAI VIRETKDCDA WKVCLRLRDN
410 420 430
GLLAKPTHGD IIRFAPPLVI KEDEILEAVE IINKTILSF
Length:439
Mass (Da):48,075
Last modified:September 27, 2005 - v1
Checksum:i3A620B0CCDE3779E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102427 mRNA. Translation: AAI02428.1.
RefSeqiNP_001029412.1. NM_001034240.1.
UniGeneiBt.49448.

Genome annotation databases

GeneIDi505323.
KEGGibta:505323.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102427 mRNA. Translation: AAI02428.1.
RefSeqiNP_001029412.1. NM_001034240.1.
UniGeneiBt.49448.

3D structure databases

ProteinModelPortaliQ3ZCF5.
SMRiQ3ZCF5. Positions 36-439.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000009097.

Proteomic databases

PaxDbiQ3ZCF5.
PRIDEiQ3ZCF5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi505323.
KEGGibta:505323.

Organism-specific databases

CTDi4942.

Phylogenomic databases

eggNOGiKOG1402. Eukaryota.
COG4992. LUCA.
HOGENOMiHOG000020206.
HOVERGENiHBG000434.
InParanoidiQ3ZCF5.
KOiK00819.

Enzyme and pathway databases

UniPathwayiUPA00098; UER00358.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
InterProiIPR005814. Aminotrans_3.
IPR010164. Orn_aminotrans.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PTHR11986:SF18. PTHR11986:SF18. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01885. Orn_aminotrans. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiOAT_BOVIN
AccessioniPrimary (citable) accession number: Q3ZCF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: September 27, 2005
Last modified: June 8, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.