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Protein

U6 snRNA-associated Sm-like protein LSm8

Gene

LSM8

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Binds specifically to the 3'-terminal U-tract of U6 snRNA and is probably a component of the spliceosome.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-BTA-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
U6 snRNA-associated Sm-like protein LSm8
Gene namesi
Name:LSM8
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 4

Organism-specific databases

VGNCiVGNC:31060 LSM8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002386722 – 96U6 snRNA-associated Sm-like protein LSm8Add BLAST95

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ3ZCE0
PRIDEiQ3ZCE0

Expressioni

Gene expression databases

BgeeiENSBTAG00000012649

Interactioni

Subunit structurei

LSm subunits form a heteromer with a doughnut shape.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000016780

Structurei

3D structure databases

ProteinModelPortaliQ3ZCE0
SMRiQ3ZCE0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the snRNP Sm proteins family.Curated

Phylogenomic databases

eggNOGiKOG1784 Eukaryota
ENOG41124H7 LUCA
GeneTreeiENSGT00730000111212
HOVERGENiHBG105578
InParanoidiQ3ZCE0
KOiK12627
OMAiGYVDRRV
OrthoDBiEOG091G126L
TreeFamiTF314555

Family and domain databases

CDDicd01727 LSm8, 1 hit
InterProiView protein in InterPro
IPR034103 Lsm8
IPR001163 LSM_dom_euk/arc
IPR010920 LSM_dom_sf
PfamiView protein in Pfam
PF01423 LSM, 1 hit
SMARTiView protein in SMART
SM00651 Sm, 1 hit
SUPFAMiSSF50182 SSF50182, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3ZCE0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSALENYIN RTVAVITSDG RMIVGTLKGF DQTINLILDE SHERVFSSSQ
60 70 80 90
GVEQVVLGLY IVRGDNVAVI GEIDEETDSA LDLGNIRAEP LNSVAH
Length:96
Mass (Da):10,403
Last modified:January 23, 2007 - v3
Checksum:i15D26E6B75AA2EE1
GO

Sequence cautioni

The sequence ABE96774 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY644517 Genomic DNA Translation: ABE96774.2 Different initiation.
BC102499 mRNA Translation: AAI02500.1
RefSeqiNP_001029912.1, NM_001034740.2
UniGeneiBt.73360

Genome annotation databases

EnsembliENSBTAT00000016780; ENSBTAP00000016780; ENSBTAG00000012649
GeneIDi613630
KEGGibta:613630

Similar proteinsi

Entry informationi

Entry nameiLSM8_BOVIN
AccessioniPrimary (citable) accession number: Q3ZCE0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 88 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health