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Protein

U6 snRNA-associated Sm-like protein LSm8

Gene

LSM8

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Binds specifically to the 3'-terminal U-tract of U6 snRNA and is probably a component of the spliceosome.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-BTA-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
U6 snRNA-associated Sm-like protein LSm8
Gene namesi
Name:LSM8
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 4

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 9695U6 snRNA-associated Sm-like protein LSm8PRO_0000238672Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylthreonineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ3ZCE0.

Interactioni

Subunit structurei

LSm subunits form a heteromer with a doughnut shape.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000016780.

Structurei

3D structure databases

ProteinModelPortaliQ3ZCE0.
SMRiQ3ZCE0. Positions 2-74.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the snRNP Sm proteins family.Curated

Phylogenomic databases

eggNOGiKOG1784. Eukaryota.
ENOG41124H7. LUCA.
GeneTreeiENSGT00730000111212.
HOVERGENiHBG105578.
InParanoidiQ3ZCE0.
KOiK12627.
OMAiSYVNHTV.
OrthoDBiEOG7SV0XS.
TreeFamiTF314555.

Family and domain databases

InterProiIPR010920. LSM_dom.
IPR001163. LSM_dom_euk/arc.
[Graphical view]
PfamiPF01423. LSM. 1 hit.
[Graphical view]
SMARTiSM00651. Sm. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3ZCE0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSALENYIN RTVAVITSDG RMIVGTLKGF DQTINLILDE SHERVFSSSQ
60 70 80 90
GVEQVVLGLY IVRGDNVAVI GEIDEETDSA LDLGNIRAEP LNSVAH
Length:96
Mass (Da):10,403
Last modified:January 23, 2007 - v3
Checksum:i15D26E6B75AA2EE1
GO

Sequence cautioni

The sequence ABE96774.2 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY644517 Genomic DNA. Translation: ABE96774.2. Different initiation.
BC102499 mRNA. Translation: AAI02500.1.
RefSeqiNP_001029912.1. NM_001034740.2.
UniGeneiBt.73360.

Genome annotation databases

EnsembliENSBTAT00000016780; ENSBTAP00000016780; ENSBTAG00000012649.
GeneIDi613630.
KEGGibta:613630.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY644517 Genomic DNA. Translation: ABE96774.2. Different initiation.
BC102499 mRNA. Translation: AAI02500.1.
RefSeqiNP_001029912.1. NM_001034740.2.
UniGeneiBt.73360.

3D structure databases

ProteinModelPortaliQ3ZCE0.
SMRiQ3ZCE0. Positions 2-74.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000016780.

Proteomic databases

PaxDbiQ3ZCE0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000016780; ENSBTAP00000016780; ENSBTAG00000012649.
GeneIDi613630.
KEGGibta:613630.

Organism-specific databases

CTDi51691.

Phylogenomic databases

eggNOGiKOG1784. Eukaryota.
ENOG41124H7. LUCA.
GeneTreeiENSGT00730000111212.
HOVERGENiHBG105578.
InParanoidiQ3ZCE0.
KOiK12627.
OMAiSYVNHTV.
OrthoDBiEOG7SV0XS.
TreeFamiTF314555.

Enzyme and pathway databases

ReactomeiR-BTA-72163. mRNA Splicing - Major Pathway.

Family and domain databases

InterProiIPR010920. LSM_dom.
IPR001163. LSM_dom_euk/arc.
[Graphical view]
PfamiPF01423. LSM. 1 hit.
[Graphical view]
SMARTiSM00651. Sm. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Conrad M.L., Mawer M.A., Davis S.K., Koop B.F.
    Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiLSM8_BOVIN
AccessioniPrimary (citable) accession number: Q3ZCE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: January 23, 2007
Last modified: June 8, 2016
This is version 79 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.