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Protein

CD81 antigen

Gene

CD81

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play an important role in the regulation of lymphoma cell growth.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
CD81 antigen
Alternative name(s):
CD_antigen: CD81
Gene namesi
Name:CD81
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12CytoplasmicSequence analysisAdd BLAST12
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Topological domaini34 – 57ExtracellularSequence analysisAdd BLAST24
Transmembranei58 – 78HelicalSequence analysisAdd BLAST21
Topological domaini79 – 89CytoplasmicSequence analysisAdd BLAST11
Transmembranei90 – 115HelicalSequence analysisAdd BLAST26
Topological domaini116 – 201ExtracellularSequence analysisAdd BLAST86
Transmembranei202 – 226HelicalSequence analysisAdd BLAST25
Topological domaini227 – 236CytoplasmicSequence analysis10

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002849601 – 236CD81 antigenAdd BLAST236

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi156 ↔ 190By similarity
Disulfide bondi157 ↔ 175By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ3ZCD0.
PeptideAtlasiQ3ZCD0.
PRIDEiQ3ZCD0.

Interactioni

Subunit structurei

Homodimer. Interacts directly with IGSF8. Interacts with CD53 and SCIMP. Interacts with IFITM1, IFITM2 and IFITM3. Part of a GPCR-tetraspanin complex consisting at least of ADGRG1, CD81, eventually CD9, and GNA11 in which CD81 is enhancing the association of ADGRG1 with GNA11. Interacts with CLDN1, CLDN6 and CLDN9.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000054606.

Structurei

3D structure databases

ProteinModelPortaliQ3ZCD0.
SMRiQ3ZCD0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
HOVERGENiHBG002324.
InParanoidiQ3ZCD0.
KOiK06508.

Family and domain databases

Gene3Di1.10.1450.10. 1 hit.
InterProiView protein in InterPro
IPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
PfamiView protein in Pfam
PF00335. Tetraspannin. 1 hit.
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiView protein in PROSITE
PS00421. TM4_1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3ZCD0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVEGCTKCI KYLLFVFNFV FWLAGGVILG VALWLRHDPQ TTNLLYLELG
60 70 80 90 100
DRPAPNTFYV GIYILIAVGA VMMFVGFLGC YGAIQESQCL LGTFFTCLVI
110 120 130 140 150
LFACEVAAGI WGFVNKDQIA KDVKQFYDQA LQQAIVDDDA NNAKAVVKTF
160 170 180 190 200
HETLNCCGSN TLMTLTTSVL KNSLCPSSGN VITNLFKEDC HGKIDELFSG
210 220 230
KLYLIGIAAI VVAVIMIFEM ILSMVLCCGI RNSSVY
Length:236
Mass (Da):25,854
Last modified:September 27, 2005 - v1
Checksum:i3A4B6BAE3875228E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102513 mRNA. Translation: AAI02514.1.
RefSeqiNP_001030271.1. NM_001035099.1.
UniGeneiBt.51424.

Genome annotation databases

GeneIDi511435.
KEGGibta:511435.

Similar proteinsi

Entry informationi

Entry nameiCD81_BOVIN
AccessioniPrimary (citable) accession number: Q3ZCD0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: September 27, 2005
Last modified: August 30, 2017
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families