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Protein

Leucine-rich repeat-containing protein 39

Gene

LRRC39

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the sarcomeric M-band which plays a role in myocyte response to biomechanical stress. May regulate expression of other M-band proteins via an SRF-dependent pathway. Important for normal contractile function in heart.By similarity

Keywordsi

Molecular functionMuscle protein

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 39Curated
Alternative name(s):
Myosin-interacting M-band-associated stress-responsive proteinBy similarity
Short name:
MyomaspBy similarity
Gene namesi
Name:LRRC39By similarity
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 3

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002325791 – 334Leucine-rich repeat-containing protein 39Add BLAST334

Proteomic databases

PaxDbiQ3ZC49.
PRIDEiQ3ZC49.

Expressioni

Gene expression databases

BgeeiENSBTAG00000015786.

Interactioni

Subunit structurei

Interacts with MYH7 (via C-terminus).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000048641.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati84 – 105LRR 1Add BLAST22
Repeati107 – 128LRR 2Add BLAST22
Repeati130 – 151LRR 3Add BLAST22
Repeati153 – 176LRR 4Add BLAST24
Repeati177 – 198LRR 5Add BLAST22
Repeati200 – 221LRR 6Add BLAST22
Repeati223 – 244LRR 7Add BLAST22
Repeati246 – 267LRR 8Add BLAST22
Repeati269 – 290LRR 9Add BLAST22

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili10 – 47Sequence analysisAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi293 – 299Poly-Glu7

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00840000129686.
HOGENOMiHOG000065739.
HOVERGENiHBG101376.
InParanoidiQ3ZC49.
OMAiCMEEMTN.
OrthoDBiEOG091G0CW0.
TreeFamiTF333627.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiView protein in InterPro
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR032675. LRR_dom_sf.
PfamiView protein in Pfam
PF13855. LRR_8. 3 hits.
SMARTiView protein in SMART
SM00369. LRR_TYP. 6 hits.
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiView protein in PROSITE
PS51450. LRR. 7 hits.

Sequencei

Sequence statusi: Complete.

Q3ZC49-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSENVVSTGA VNAVKEVWEK RIKKLNEDLK REKEFQQKLV RIWEERVCLT
60 70 80 90 100
KLREKVTKED GRVILKIEKE EWKTLPSSLL KLNQLQEWQL HRIGLLKIPE
110 120 130 140 150
FIGRFQNLIV LDLSRNTITE IPRGIGLLTR LQELILSYNR IKTVPMELSY
160 170 180 190 200
CASLEKLELA VNRDISDLPQ ELSNLLKLTH LDLSMNLFTT IPPAVLNMPA
210 220 230 240 250
LEWLDMGSNR LEQLPDTIER MQNLHTLWLQ RNEITCLPET ISSMKNLSTL
260 270 280 290 300
VLSNNKLQDI PVCMEKMTNL RFVNFRDNPL KLEVTLPPSE NIEEEEEREL
310 320 330
FGLQFMHTYI QESRRAGNQV NCSTTSPNSI DADG
Length:334
Mass (Da):38,787
Last modified:September 27, 2005 - v1
Checksum:i66BA286F1415AD13
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102917 mRNA. Translation: AAI02918.1.
RefSeqiNP_001069893.1. NM_001076425.1.
UniGeneiBt.49463.

Genome annotation databases

EnsembliENSBTAT00000053822; ENSBTAP00000048641; ENSBTAG00000015786.
GeneIDi616488.
KEGGibta:616488.

Similar proteinsi

Entry informationi

Entry nameiLRC39_BOVIN
AccessioniPrimary (citable) accession number: Q3ZC49
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: September 27, 2005
Last modified: November 22, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome