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Q3ZC31

- HEM0_BOVIN

UniProt

Q3ZC31 - HEM0_BOVIN

Protein

5-aminolevulinate synthase, erythroid-specific, mitochondrial

Gene

ALAS2

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (27 Sep 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2.

    Cofactori

    Pyridoxal phosphate.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei163 – 1631SubstrateBy similarity
    Binding sitei280 – 2801SubstrateBy similarity
    Binding sitei299 – 2991SubstrateBy similarity
    Binding sitei332 – 3321Pyridoxal phosphateBy similarity
    Binding sitei360 – 3601Pyridoxal phosphateBy similarity
    Binding sitei388 – 3881Pyridoxal phosphateBy similarity
    Active sitei391 – 3911By similarity
    Binding sitei420 – 4201Pyridoxal phosphateBy similarity
    Binding sitei421 – 4211Pyridoxal phosphateBy similarity
    Binding sitei508 – 5081SubstrateBy similarity

    GO - Molecular functioni

    1. 5-aminolevulinate synthase activity Source: UniProtKB
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. cellular iron ion homeostasis Source: Ensembl
    2. erythrocyte differentiation Source: Ensembl
    3. hemoglobin biosynthetic process Source: Ensembl
    4. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
    5. response to hypoxia Source: UniProtKB

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Heme biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    ReactomeiREACT_212036. Heme biosynthesis.
    UniPathwayiUPA00251; UER00375.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5-aminolevulinate synthase, erythroid-specific, mitochondrial (EC:2.3.1.37)
    Short name:
    ALAS-E
    Alternative name(s):
    5-aminolevulinic acid synthase 2
    Delta-ALA synthase 2
    Delta-aminolevulinate synthase 2
    Gene namesi
    Name:ALAS2
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome X

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: UniProtKB
    2. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – ?4949MitochondrionSequence AnalysisAdd
    BLAST
    Chaini?50 – 5875385-aminolevulinate synthase, erythroid-specific, mitochondrialPRO_0000280705Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei391 – 3911N6-(pyridoxal phosphate)lysineCurated

    Proteomic databases

    PRIDEiQ3ZC31.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with SUCLA2 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000017538.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3ZC31.
    SMRiQ3ZC31. Positions 1-49, 145-540.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0156.
    GeneTreeiENSGT00530000063111.
    HOGENOMiHOG000221020.
    HOVERGENiHBG005954.
    InParanoidiQ3ZC31.
    KOiK00643.
    OMAiHYLQSIN.
    OrthoDBiEOG7TQV0F.
    TreeFamiTF300724.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR010961. 4pyrrol_synth_NH2levulA_synth.
    IPR015118. 5aminolev_synth_preseq.
    IPR001917. Aminotrans_II_pyridoxalP_BS.
    IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PfamiPF00155. Aminotran_1_2. 1 hit.
    PF09029. Preseq_ALAS. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01821. 5aminolev_synth. 1 hit.
    PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q3ZC31-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVTAAMLLQR CPVLIRSPTG LLGKMIKTHQ FLFGIGRCPI LATQGPSFSQ    50
    IHLKATKAGG DSPSWAKSHC PFMLLELQDG KSKIVQKAAP EVQEDVKTFK 100
    TDLPTSLAST SLKKTFSSPQ EPEKNSEKVT HLIQNNMAGD HVFGYDQFFR 150
    DKIMEKKQDH TYRVFKTVNR WADAYPFAEH FFEASVASKD VSVWCSNDYL 200
    GMSRHPRVLQ ATQEILQRHG AGAGGTRNIS GTSKFHVELE QELAELHQKD 250
    SALLFSSCFV ANDSTLFTLA KILPGCEIYS DAGNHASMIQ GIRNSGAAKF 300
    VFRHNDPDHL KKLLKKSNPE TPKIVAFETV HSMDGAICPL EELCDVAHQY 350
    GALTFVDEVH AVGLYGSRGA GIGERDGIMH KIDIISGTLG KAFGCVGGYI 400
    ASTRDLVDMV RSYAAGFIFT TSLPPMVLSG ALESVRLLKG EEGQALRRAH 450
    QRNVKHMRQL LMDRGLPVIP CPSHIIPIRV GDAMLNTRIC DLLLSKYGIY 500
    VQAINYPTVP RGEELLRLAP SPHHSPQMME DFVEKLLEAW TEVGLPLQDI 550
    SIAACNFCRR PVHFELMSEW ERSYFGNMGP QYVTTYA 587
    Length:587
    Mass (Da):65,137
    Last modified:September 27, 2005 - v1
    Checksum:i8D0D94383137F5DC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC102938 mRNA. Translation: AAI02939.1.
    RefSeqiNP_001030275.1. NM_001035103.2.
    UniGeneiBt.49467.

    Genome annotation databases

    EnsembliENSBTAT00000017538; ENSBTAP00000017538; ENSBTAG00000013178.
    GeneIDi511791.
    KEGGibta:511791.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC102938 mRNA. Translation: AAI02939.1 .
    RefSeqi NP_001030275.1. NM_001035103.2.
    UniGenei Bt.49467.

    3D structure databases

    ProteinModelPortali Q3ZC31.
    SMRi Q3ZC31. Positions 1-49, 145-540.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000017538.

    Proteomic databases

    PRIDEi Q3ZC31.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000017538 ; ENSBTAP00000017538 ; ENSBTAG00000013178 .
    GeneIDi 511791.
    KEGGi bta:511791.

    Organism-specific databases

    CTDi 212.

    Phylogenomic databases

    eggNOGi COG0156.
    GeneTreei ENSGT00530000063111.
    HOGENOMi HOG000221020.
    HOVERGENi HBG005954.
    InParanoidi Q3ZC31.
    KOi K00643.
    OMAi HYLQSIN.
    OrthoDBi EOG7TQV0F.
    TreeFami TF300724.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00375 .
    Reactomei REACT_212036. Heme biosynthesis.

    Miscellaneous databases

    NextBioi 20870099.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR010961. 4pyrrol_synth_NH2levulA_synth.
    IPR015118. 5aminolev_synth_preseq.
    IPR001917. Aminotrans_II_pyridoxalP_BS.
    IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    Pfami PF00155. Aminotran_1_2. 1 hit.
    PF09029. Preseq_ALAS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01821. 5aminolev_synth. 1 hit.
    PROSITEi PS00599. AA_TRANSFER_CLASS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Fetal liver.

    Entry informationi

    Entry nameiHEM0_BOVIN
    AccessioniPrimary (citable) accession number: Q3ZC31
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 2007
    Last sequence update: September 27, 2005
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    There are two delta-ALA synthases in vertebrates: an erythroid- specific form and one (housekeeping) which is expressed in all tissues.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3