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Q3ZC31 (HEM0_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
5-aminolevulinate synthase, erythroid-specific, mitochondrial

Short name=ALAS-E
EC=2.3.1.37
Alternative name(s):
5-aminolevulinic acid synthase 2
Delta-ALA synthase 2
Delta-aminolevulinate synthase 2
Gene names
Name:ALAS2
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length587 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2.

Cofactor

Pyridoxal phosphate By similarity.

Pathway

Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from glycine: step 1/1.

Subunit structure

Homodimer. Interacts with SUCLA2 By similarity.

Subcellular location

Mitochondrion matrix By similarity.

Miscellaneous

There are two delta-ALA synthases in vertebrates: an erythroid- specific form and one (housekeeping) which is expressed in all tissues.

Sequence similarities

Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?4949Mitochondrion Potential
Chain?50 – 5875385-aminolevulinate synthase, erythroid-specific, mitochondrial
PRO_0000280705

Sites

Active site3911 By similarity
Binding site1631Substrate By similarity
Binding site2801Substrate By similarity
Binding site2991Substrate By similarity
Binding site3321Pyridoxal phosphate By similarity
Binding site3601Pyridoxal phosphate By similarity
Binding site3881Pyridoxal phosphate By similarity
Binding site4201Pyridoxal phosphate By similarity
Binding site4211Pyridoxal phosphate By similarity
Binding site5081Substrate By similarity

Amino acid modifications

Modified residue3911N6-(pyridoxal phosphate)lysine Probable

Sequences

Sequence LengthMass (Da)Tools
Q3ZC31 [UniParc].

Last modified September 27, 2005. Version 1.
Checksum: 8D0D94383137F5DC

FASTA58765,137
        10         20         30         40         50         60 
MVTAAMLLQR CPVLIRSPTG LLGKMIKTHQ FLFGIGRCPI LATQGPSFSQ IHLKATKAGG 

        70         80         90        100        110        120 
DSPSWAKSHC PFMLLELQDG KSKIVQKAAP EVQEDVKTFK TDLPTSLAST SLKKTFSSPQ 

       130        140        150        160        170        180 
EPEKNSEKVT HLIQNNMAGD HVFGYDQFFR DKIMEKKQDH TYRVFKTVNR WADAYPFAEH 

       190        200        210        220        230        240 
FFEASVASKD VSVWCSNDYL GMSRHPRVLQ ATQEILQRHG AGAGGTRNIS GTSKFHVELE 

       250        260        270        280        290        300 
QELAELHQKD SALLFSSCFV ANDSTLFTLA KILPGCEIYS DAGNHASMIQ GIRNSGAAKF 

       310        320        330        340        350        360 
VFRHNDPDHL KKLLKKSNPE TPKIVAFETV HSMDGAICPL EELCDVAHQY GALTFVDEVH 

       370        380        390        400        410        420 
AVGLYGSRGA GIGERDGIMH KIDIISGTLG KAFGCVGGYI ASTRDLVDMV RSYAAGFIFT 

       430        440        450        460        470        480 
TSLPPMVLSG ALESVRLLKG EEGQALRRAH QRNVKHMRQL LMDRGLPVIP CPSHIIPIRV 

       490        500        510        520        530        540 
GDAMLNTRIC DLLLSKYGIY VQAINYPTVP RGEELLRLAP SPHHSPQMME DFVEKLLEAW 

       550        560        570        580 
TEVGLPLQDI SIAACNFCRR PVHFELMSEW ERSYFGNMGP QYVTTYA 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Fetal liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC102938 mRNA. Translation: AAI02939.1.
RefSeqNP_001030275.1. NM_001035103.2.
UniGeneBt.49467.

3D structure databases

ProteinModelPortalQ3ZC31.
SMRQ3ZC31. Positions 1-49, 145-540.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000017538.

Proteomic databases

PRIDEQ3ZC31.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000017538; ENSBTAP00000017538; ENSBTAG00000013178.
GeneID511791.
KEGGbta:511791.

Organism-specific databases

CTD212.

Phylogenomic databases

eggNOGCOG0156.
GeneTreeENSGT00530000063111.
HOGENOMHOG000221020.
HOVERGENHBG005954.
InParanoidQ3ZC31.
KOK00643.
OMAHYLQSIN.
OrthoDBEOG7TQV0F.
TreeFamTF300724.

Enzyme and pathway databases

UniPathwayUPA00251; UER00375.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProIPR010961. 4pyrrol_synth_NH2levulA_synth.
IPR015118. 5aminolev_synth_preseq.
IPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamPF00155. Aminotran_1_2. 1 hit.
PF09029. Preseq_ALAS. 1 hit.
[Graphical view]
SUPFAMSSF53383. SSF53383. 1 hit.
TIGRFAMsTIGR01821. 5aminolev_synth. 1 hit.
PROSITEPS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20870099.

Entry information

Entry nameHEM0_BOVIN
AccessionPrimary (citable) accession number: Q3ZC31
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: September 27, 2005
Last modified: May 14, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways