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Protein

Sodium/myo-inositol cotransporter 2

Gene

SLC5A11

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the sodium-dependent cotransport of myo-inositol (MI) with a Na+:MI stoichiometry of 2:1. Exclusively responsible for apical MI transport and absorption in intestine. Also can transport D-chiro-inositol (DCI) but not L-fructose. Exhibits stereospecific cotransport of both D-glucose and D-xylose. May induce apoptosis through the TNF-alpha, PDCD1 pathway. May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis, Ion transport, Sodium transport, Sugar transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiR-BTA-429593. Inositol transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/myo-inositol cotransporter 2
Short name:
Na(+)/myo-inositol cotransporter 2
Alternative name(s):
Sodium/myo-inositol transporter 2
Short name:
SMIT2
Solute carrier family 5 member 11
Gene namesi
Name:SLC5A11Imported
Synonyms:SMIT2By similarity
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 25

Subcellular locationi

  • Membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence analysisAdd
BLAST
Transmembranei26 – 4621HelicalSequence analysisAdd
BLAST
Topological domaini47 – 5610CytoplasmicSequence analysis
Transmembranei57 – 7721HelicalSequence analysisAdd
BLAST
Topological domaini78 – 10225ExtracellularSequence analysisAdd
BLAST
Transmembranei103 – 12321HelicalSequence analysisAdd
BLAST
Topological domaini124 – 14017CytoplasmicSequence analysisAdd
BLAST
Transmembranei141 – 16121HelicalSequence analysisAdd
BLAST
Topological domaini162 – 18019ExtracellularSequence analysisAdd
BLAST
Transmembranei181 – 20121HelicalSequence analysisAdd
BLAST
Topological domaini202 – 2087CytoplasmicSequence analysis
Transmembranei209 – 22921HelicalSequence analysisAdd
BLAST
Topological domaini230 – 27243ExtracellularSequence analysisAdd
BLAST
Transmembranei273 – 29321HelicalSequence analysisAdd
BLAST
Topological domaini294 – 30815CytoplasmicSequence analysisAdd
BLAST
Transmembranei309 – 32921HelicalSequence analysisAdd
BLAST
Topological domaini330 – 37445ExtracellularSequence analysisAdd
BLAST
Transmembranei375 – 39723HelicalSequence analysisAdd
BLAST
Topological domaini398 – 41821CytoplasmicSequence analysisAdd
BLAST
Transmembranei419 – 43921HelicalSequence analysisAdd
BLAST
Topological domaini440 – 4467ExtracellularSequence analysis
Transmembranei447 – 46721HelicalSequence analysisAdd
BLAST
Topological domaini468 – 47912CytoplasmicSequence analysisAdd
BLAST
Transmembranei480 – 50021HelicalSequence analysisAdd
BLAST
Topological domaini501 – 52121ExtracellularSequence analysisAdd
BLAST
Transmembranei522 – 54221HelicalSequence analysisAdd
BLAST
Topological domaini543 – 653111CytoplasmicSequence analysisAdd
BLAST
Transmembranei654 – 67421HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 674674Sodium/myo-inositol cotransporter 2PRO_0000331567Add
BLAST

Proteomic databases

PaxDbiQ3ZC26.
PRIDEiQ3ZC26.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004510.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IP49. Eukaryota.
COG4146. LUCA.
GeneTreeiENSGT00760000118955.
HOGENOMiHOG000025422.
HOVERGENiHBG052859.
InParanoidiQ3ZC26.
KOiK14391.
OMAiWSMWRTK.
OrthoDBiEOG77126J.
TreeFamiTF352855.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 2 hits.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3ZC26-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESSASSPPL TQSDPLEAFP RRTLEAGDIA VLVLYFLFVL AVGLWSTVKT
60 70 80 90 100
KRDTVKGYFL AGGNMLWWPV GASLFASNVG SGHFVGLAGS GAAAGLSVTA
110 120 130 140 150
YELNGLFFVL MLSWIFLPIY ITGQVTTMPE YLRKRFGGNR IPIILAVLYL
160 170 180 190 200
FIYIFTKISV DMYAGAIFIQ QSLHVNLYLA IVGLLAVTAL YTIAGGLAAV
210 220 230 240 250
IYTDALQTLI MLIGALILMG YSFAAVGGLE GLEEKYFLAM ASNRSGNSSC
260 270 280 290 300
GLPREDAFHI FRDPVTSDLP WPGILFGMSI PSLWYWCTDQ VIVQRTLAAK
310 320 330 340 350
NLSHAKGGSL MAAYLKVLPL FIMVFPGMVS RVLFPDEVAC ADPEICRKVC
360 370 380 390 400
SNPAGCSDIA YPKLVLELLP TGLRGLMMAV MVAALTSSLT SIFNSASTIF
410 420 430 440 450
TMDLWNHLRP RASEKELMIV GRVFVLLLVL VSILWIPVVQ ASQGGQLFIY
460 470 480 490 500
IQSISSYLQP PVAVVFIMGC FWKRANEKGA FFGLVLGLLL GLVRLILDFI
510 520 530 540 550
YVQPRCDQLD ERPAVVKDVH YLYFSMILSS VTLITVCAVS WFTEPPSKEM
560 570 580 590 600
VSRLTWFTRH DPVVQKEQVP SATPPPLTLS QNGTPEASGT NTQFEMVQEN
610 620 630 640 650
LSKTHSCDMT TKRSKVVKAI LWLCGVENKG KEQAPSRADP IIVSLEENPL
660 670
VKTLLDLNLI ICISCAIFLW GYFA
Length:674
Mass (Da):73,957
Last modified:September 27, 2005 - v1
Checksum:iEDD042B64AE749B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102962 mRNA. Translation: AAI02963.1.
RefSeqiNP_001029832.1. NM_001034660.2.
XP_005224816.1. XM_005224759.3.
UniGeneiBt.49470.

Genome annotation databases

EnsembliENSBTAT00000004510; ENSBTAP00000004510; ENSBTAG00000003467.
GeneIDi539084.
KEGGibta:539084.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102962 mRNA. Translation: AAI02963.1.
RefSeqiNP_001029832.1. NM_001034660.2.
XP_005224816.1. XM_005224759.3.
UniGeneiBt.49470.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004510.

Proteomic databases

PaxDbiQ3ZC26.
PRIDEiQ3ZC26.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000004510; ENSBTAP00000004510; ENSBTAG00000003467.
GeneIDi539084.
KEGGibta:539084.

Organism-specific databases

CTDi115584.

Phylogenomic databases

eggNOGiENOG410IP49. Eukaryota.
COG4146. LUCA.
GeneTreeiENSGT00760000118955.
HOGENOMiHOG000025422.
HOVERGENiHBG052859.
InParanoidiQ3ZC26.
KOiK14391.
OMAiWSMWRTK.
OrthoDBiEOG77126J.
TreeFamiTF352855.

Enzyme and pathway databases

ReactomeiR-BTA-429593. Inositol transporters.

Miscellaneous databases

NextBioi20877771.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 2 hits.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X AngusImported.
    Tissue: IleumImported.

Entry informationi

Entry nameiSC5AB_BOVIN
AccessioniPrimary (citable) accession number: Q3ZC26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: September 27, 2005
Last modified: April 13, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.