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Protein

Stress-induced-phosphoprotein 1

Gene

STIP1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates the association of the molecular chaperones HSC70 and HSP90 (HSPCA and HSPCB).

Names & Taxonomyi

Protein namesi
Recommended name:
Stress-induced-phosphoprotein 1
Short name:
STI1
Alternative name(s):
Hsc70/Hsp90-organizing protein
Short name:
Hop
Gene namesi
Name:STIP1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 29

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 543543Stress-induced-phosphoprotein 1PRO_0000328059Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei8 – 81N6-acetyllysineBy similarity
Modified residuei16 – 161PhosphoserineBy similarity
Cross-linki123 – 123Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei198 – 1981PhosphothreonineBy similarity
Modified residuei301 – 3011N6-acetyllysineBy similarity
Modified residuei312 – 3121N6-acetyllysineBy similarity
Modified residuei325 – 3251N6-acetyllysineBy similarity
Modified residuei344 – 3441N6-acetyllysineBy similarity
Modified residuei354 – 3541PhosphotyrosineBy similarity
Modified residuei446 – 4461N6-acetyllysineBy similarity
Modified residuei481 – 4811PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ3ZBZ8.
PRIDEiQ3ZBZ8.

Interactioni

Subunit structurei

Forms a complex with HSC70 and HSPCA/HSP-86 and HSPCB/HSP-84. Interacts with PACRG. Interacts with METTL21B. Interacts with HSP90/HSP90AA1; the interaction dissociates the PPP5C:HSP90AA1 interaction (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020809.

Structurei

3D structure databases

ProteinModelPortaliQ3ZBZ8.
SMRiQ3ZBZ8. Positions 2-118, 223-349.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati4 – 3734TPR 1Add
BLAST
Repeati39 – 7133TPR 2Add
BLAST
Repeati73 – 10533TPR 3Add
BLAST
Domaini130 – 16940STI1 1Add
BLAST
Repeati225 – 25834TPR 4Add
BLAST
Repeati260 – 29233TPR 5Add
BLAST
Repeati300 – 33334TPR 6Add
BLAST
Repeati360 – 39334TPR 7Add
BLAST
Repeati395 – 42733TPR 8Add
BLAST
Repeati428 – 46134TPR 9Add
BLAST
Domaini492 – 53140STI1 2Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi222 – 23918Bipartite nuclear localization signalSequence analysisAdd
BLAST

Domaini

The TPR 1 repeat interacts with the C-terminal of HSC70. The TPR 4, 5 and 6 repeats (also called TPR2A domain) and TPR 7, 8 and 9 repeats (also called TPR2B domain) interact with HSP90 (By similarity).By similarity

Sequence similaritiesi

Contains 2 STI1 domains.Curated
Contains 9 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0548. Eukaryota.
ENOG410XTCJ. LUCA.
GeneTreeiENSGT00840000129761.
HOGENOMiHOG000186562.
HOVERGENiHBG057820.
InParanoidiQ3ZBZ8.
KOiK09553.
OMAiSKCRELC.
OrthoDBiEOG7BGHM5.
TreeFamiTF300478.

Family and domain databases

Gene3Di1.25.40.10. 3 hits.
InterProiIPR006636. STI1_HS-bd.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF13414. TPR_11. 2 hits.
PF13181. TPR_8. 2 hits.
[Graphical view]
SMARTiSM00727. STI1. 2 hits.
SM00028. TPR. 9 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 3 hits.
PROSITEiPS50005. TPR. 9 hits.
PS50293. TPR_REGION. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3ZBZ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQVNELKEK GNKALSAGNI DDALQCYSEA IKLDPQNHVL YSNRSAAYAK
60 70 80 90 100
KGDYQKAYED GCKTVDLKPD WGKGYSRKAA ALEFLNRFEE AKQTYEEGLK
110 120 130 140 150
HEANNPQLKE GLQNMEARLA ERKFMNPFNM PNLYQKLESD PRTKTLLADP
160 170 180 190 200
TYRELIEQLR NKPSDLGTKL QDPRIMTTLS VLLGVDLGSM DEEEEVATPP
210 220 230 240 250
PPPPPKKETK PEPMEEDLPE NKKQALREKE LGNEAYKKKD FDTALKHYDK
260 270 280 290 300
AKDLDPTNMT YITNQAAVYF EKGDYGQCRE LCEKAIEVGR ENREDYRQIA
310 320 330 340 350
KAYARIGNSY FKEEKYKDAI HFYNKSLAEH RTPDVLKKCQ QAEKILKEQE
360 370 380 390 400
RLAYINPDLA LEEKNKGNEC FQKGDYPQAM KHYTEAIKRN PKDAKLYSNR
410 420 430 440 450
AACYTKLLEF QLALKDCEEC IQLEPTFIKG YTRKAAALEA MKDYTKAMDV
460 470 480 490 500
YQKALDLDSN CKEAADGYQR CVMAQYNRHD SPEDVKRRAM ADPEVQQIMS
510 520 530 540
DPAMRLILEQ MQKDPQALSE HLKNPVIAQK IQKLMDVGLI AIR
Length:543
Mass (Da):62,482
Last modified:September 27, 2005 - v1
Checksum:iE040632F03E61306
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103003 mRNA. Translation: AAI03004.1.
RefSeqiNP_001030569.1. NM_001035492.2.
UniGeneiBt.49324.

Genome annotation databases

EnsembliENSBTAT00000020809; ENSBTAP00000020809; ENSBTAG00000015663.
GeneIDi617109.
KEGGibta:617109.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103003 mRNA. Translation: AAI03004.1.
RefSeqiNP_001030569.1. NM_001035492.2.
UniGeneiBt.49324.

3D structure databases

ProteinModelPortaliQ3ZBZ8.
SMRiQ3ZBZ8. Positions 2-118, 223-349.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020809.

Proteomic databases

PaxDbiQ3ZBZ8.
PRIDEiQ3ZBZ8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000020809; ENSBTAP00000020809; ENSBTAG00000015663.
GeneIDi617109.
KEGGibta:617109.

Organism-specific databases

CTDi10963.

Phylogenomic databases

eggNOGiKOG0548. Eukaryota.
ENOG410XTCJ. LUCA.
GeneTreeiENSGT00840000129761.
HOGENOMiHOG000186562.
HOVERGENiHBG057820.
InParanoidiQ3ZBZ8.
KOiK09553.
OMAiSKCRELC.
OrthoDBiEOG7BGHM5.
TreeFamiTF300478.

Family and domain databases

Gene3Di1.25.40.10. 3 hits.
InterProiIPR006636. STI1_HS-bd.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF13414. TPR_11. 2 hits.
PF13181. TPR_8. 2 hits.
[Graphical view]
SMARTiSM00727. STI1. 2 hits.
SM00028. TPR. 9 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 3 hits.
PROSITEiPS50005. TPR. 9 hits.
PS50293. TPR_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Thymus.

Entry informationi

Entry nameiSTIP1_BOVIN
AccessioniPrimary (citable) accession number: Q3ZBZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: September 27, 2005
Last modified: June 8, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.