Reviewed, UniProtKB/Swiss-Prot Q3ZBX1 (PIGC_BOVIN)

Names and origin

Protein names

Recommended name:
    Phosphatidylinositol N-acetylglucosaminyltransferase subunit C
    EC=2.4.1.198
Alternative name(s):
    Phosphatidylinositol-glycan biosynthesis class C protein
      Short name=PIG-C

Gene names

Name:

PIGC

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	297 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis By similarity.
Catalytic activity	UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol.
Pathway	Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.
Subunit structure	Associates with PIGA, PIGH, PIGP, PIGQ and DPM2. The latter is not essential for activity By similarity.
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the PIGC family.

Ontologies

Keywords
Biological process	GPI-anchor biosynthesis
Cellular component	Endoplasmic reticulum Membrane
Domain	Transmembrane
Molecular function	Glycosyltransferase Transferase
Gene Ontology (GO)
Biological process	GPI anchor biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	phosphatidylinositol N-acetylglucosaminyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 297	297	Phosphatidylinositol N-acetylglucosaminyltransferase subunit C		PRO_0000365731
Regions
	Transmembrane	67 – 87	21	Potential
	Transmembrane	88 – 108	21	Potential
	Transmembrane	153 – 173	21	Potential
	Transmembrane	239 – 259	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q3ZBX1-1 [UniParc]. Last modified September 27, 2005. Version 1. Checksum: A79B4E4B04D8D80B	FASTA	297	33,628
	10 20 30 40 50 60 MCAQPVANTK EVRWQKVLYE RQPFPDNYVD RRFLEELRKN IYARKYQYWA VVFESSVVIQ 70 80 90 100 110 120 QLCSVCVFVV IWWYMDEGLL APQWLFGTGL ASSLIGYVLF DFIDGGEGRK KSGRTRWADL 130 140 150 160 170 180 KSALVFITFT YGFSPVLKTL TESVSTDTIY AMAVFMLLGH LIFFDYGANA AIVSSTLSLN 190 200 210 220 230 240 MAIFASVCLA SRLPRSLHAF IMVTFAIQIF ALWPMLQKKL KACTPRSYVG VTLLFAFSAL 250 260 270 280 290 GGLLSISAVG AILFALLLIS ISCLCPFYLI RLQLFKENIH GPWDEAEIKE DLSRFLS

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Fetal liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC103058 mRNA. Translation: AAI03059.1.
IPI	IPI00695790.
RefSeq	NP_001029555.1.
UniGene	Bt.49348
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q3ZBX1.
Genome annotation databases
Ensembl	ENSBTAT00000034135; ENSBTAP00000034036; ENSBTAG00000024542; Bos taurus. [Genome view]
GeneID	510483.
KEGG	bta:510483.
Organism-specific databases
CTD	510483.
Phylogenomic databases
HOVERGEN	Q3ZBX1.
OMA	VVIQQLC.
Family and domain databases
InterPro	IPR009450. Plno_GlcNAc_GPI2. [Graphical view]
PANTHER	PTHR12982. GPI2. 1 hit.
Pfam	PF06432. GPI2. 1 hit. [Graphical view]
PIRSF	PIRSF016104. GPI2. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PIGC_BOVIN

Accession

Primary (citable) accession number: Q3ZBX1

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 3, 2009
Last sequence update:	September 27, 2005
Last modified:	November 3, 2009
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)