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Reviewed, UniProtKB/Swiss-Prot Q3ZBW2 (HAOX2_BOVIN)

Last modified November 25, 2008. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Hydroxyacid oxidase 2
      Short name=HAOX2
    EC=1.1.3.15
Alternative name(s):
    (S)-2-hydroxy-acid oxidase, peroxisomal
Gene names
Name: HAO2
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

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Protein attributes

Sequence length353 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Catalytic activity

(S)-2-hydroxy acid + O(2) = 2-oxo acid + H(2)O(2).

Cofactor

FMN By similarity.

Subunit structure

Homotetramer or homooctamer By similarity.

Subcellular location

PeroxisomeBy similarity.

Sequence similarities

Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

Contains 1 FMN hydroxy acid dehydrogenase domain.

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Ontologies

Keywords

   Cellular componentPeroxisome
   LigandFMN
Flavoprotein
   Molecular functionOxidoreductase

Gene Ontology (GO)

   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentperoxisome

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular function(S)-2-hydroxy-acid oxidase activity

Inferred from electronic annotation. Source: EC

FMN binding

Inferred from electronic annotation. Source: InterPro

electron carrier activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 353353Hydroxyacid oxidase 2
PRO_0000285088

Regions

Domain1 – 353353FMN hydroxy acid dehydrogenase
Nucleotide binding279 – 30325FMN By similarity
Motif351 – 3533Microbody targeting signal Potential

Sites

Active site2481Proton acceptor By similarity
Binding site1061FMN By similarity
Binding site1281FMN By similarity
Binding site1301Substrate By similarity
Binding site1561FMN By similarity
Binding site1651Substrate By similarity
Binding site2241FMN By similarity
Binding site2511Substrate Potential

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Sequences

Sequence LengthMass (Da)Tools
Q3ZBW2-1 [UniParc].

Last modified September 27, 2005. Version 1.
Checksum: E20D09034252F692

FASTA35339,253
        10         20         30         40         50         60 
MPLVCLTDFR EHAREHLSKS TWDFIEGGAD DCCTRDENMA AFKKIRLRPR YLKDVSKVDM 

        70         80         90        100        110        120 
RTTIQGAEIS APICIAPTGF HRLAWPDGEM STARAAQAAS ICYITSTYAS CSLEDIVAAA 

       130        140        150        160        170        180 
PRGLRWFQLY VHPNRQINKQ MIQKVESLGF KALVITVDVP KVGNRRNDIT NQVDLMKKLL 

       190        200        210        220        230        240 
LKDLGSPEMG NVMPYFQMSP IDPSICWEDL SWFQSMTRLP IILKGILTKE DAELAVKHNV 

       250        260        270        280        290        300 
HGIIVSNHGG RQLDEVPASI DALTEVVAAV KGKVEVYLDG GIRTGNDVLK ALALGAKCVF 

       310        320        330        340        350 
VGRPILWGLA YKGEHGVKEV LDILKNEFHT SMTLTGCRSV AEINQDLIQF SRL

« Hide

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References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Fetal liver.

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Cross-references

Sequence databases

BC103070 mRNA. Translation: AAI03071.1.
RefSeqNP_001030243.1.
UniGeneBt.46051

3D structure databases

SMRQ3ZBW2. Positions 2-350.
ModBaseSearch...

Genome annotation databases

EnsemblENSBTAG00000000123. Bos taurus. [Contig view]
GeneID509481.
KEGGbta:509481.

Phylogenomic databases

HOVERGENQ3ZBW2.

Family and domain databases

InterProIPR013785. Aldolase_TIM.
IPR012133. Alpha_OHA_DHase_FMN.
IPR008259. FMN_hydac_DHase_AS.
IPR000262. FMN_OHA_DHase.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PfamPF01070. FMN_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITEPS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameHAOX2_BOVIN
AccessionPrimary (citable) accession number: Q3ZBW2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: September 27, 2005
Last modified: November 25, 2008
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents