Reviewed,
UniProtKB/Swiss-Prot Q3ZBW2 (HAOX2_BOVIN)
Last modified
November 25, 2008.
Version 31.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Hydroxyacid oxidase 2 Short name=HAOX2 EC=1.1.3.15 Alternative name(s): (S)-2-hydroxy-acid oxidase, peroxisomal | ||
| Gene names |
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| Organism | Bos taurus (Bovine) | ||
| Taxonomic identifier | 9913 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Protein attributes
| Sequence length | 353 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Catalytic activity | (S)-2-hydroxy acid + O(2) = 2-oxo acid + H(2)O(2). |
| Cofactor | FMN By similarity. |
| Subunit structure | Homotetramer or homooctamer By similarity. |
| Subcellular location | PeroxisomeBy similarity. |
| Sequence similarities | Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. Contains 1 FMN hydroxy acid dehydrogenase domain. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Peroxisome |
| Ligand | FMN Flavoprotein |
| Molecular function | Oxidoreductase |
Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | peroxisome Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | (S)-2-hydroxy-acid oxidase activity Inferred from electronic annotation. Source: EC FMN bindingInferred from electronic annotation. Source: InterPro electron carrier activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 353 | 353 | Hydroxyacid oxidase 2 | PRO_0000285088 | |||||
Regions | |||||||||
| Domain | 1 – 353 | 353 | FMN hydroxy acid dehydrogenase | ||||||
| Nucleotide binding | 279 – 303 | 25 | FMN By similarity | ||||||
| Motif | 351 – 353 | 3 | Microbody targeting signal Potential | ||||||
Sites | |||||||||
| Active site | 248 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 106 | 1 | FMN By similarity | ||||||
| Binding site | 128 | 1 | FMN By similarity | ||||||
| Binding site | 130 | 1 | Substrate By similarity | ||||||
| Binding site | 156 | 1 | FMN By similarity | ||||||
| Binding site | 165 | 1 | Substrate By similarity | ||||||
| Binding site | 224 | 1 | FMN By similarity | ||||||
| Binding site | 251 | 1 | Substrate Potential | ||||||
Sequences
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References
| [1] | NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Fetal liver. |
Cross-references
Sequence databases | |
|---|---|
| BC103070 mRNA. Translation: AAI03071.1. | |
| RefSeq | NP_001030243.1. |
| UniGene | Bt.46051 |
3D structure databases | |
| SMR | Q3ZBW2. Positions 2-350. |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSBTAG00000000123. Bos taurus. [Contig view] |
| GeneID | 509481. |
| KEGG | bta:509481. |
Phylogenomic databases | |
| HOVERGEN | Q3ZBW2. |
Family and domain databases | |
| InterPro | IPR013785. Aldolase_TIM. IPR012133. Alpha_OHA_DHase_FMN. IPR008259. FMN_hydac_DHase_AS. IPR000262. FMN_OHA_DHase. [Graphical view] |
| Gene3D | G3DSA:3.20.20.70. Aldolase_TIM. 1 hit. |
| Pfam | PF01070. FMN_dh. 1 hit. [Graphical view] |
| PIRSF | PIRSF000138. Al-hdrx_acd_dh. 1 hit. |
| PROSITE | PS00557. FMN_HYDROXY_ACID_DH_1. 1 hit. PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | HAOX2_BOVIN | ||||||||
| Accession | Primary (citable) accession number: Q3ZBW2 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||

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