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Q3ZBW2

- HAOX2_BOVIN

UniProt

Q3ZBW2 - HAOX2_BOVIN

Protein

Hydroxyacid oxidase 2

Gene

HAO2

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (27 Sep 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2.

    Cofactori

    FMN.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei106 – 1061FMNPROSITE-ProRule annotation
    Binding sitei128 – 1281FMNPROSITE-ProRule annotation
    Binding sitei130 – 1301SubstratePROSITE-ProRule annotation
    Binding sitei156 – 1561FMNPROSITE-ProRule annotation
    Binding sitei165 – 1651SubstratePROSITE-ProRule annotation
    Binding sitei224 – 2241FMNPROSITE-ProRule annotation
    Active sitei248 – 2481Proton acceptorPROSITE-ProRule annotation
    Binding sitei251 – 2511SubstratePROSITE-ProRule annotation
    Binding sitei303 – 3031FMNPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi279 – 30325FMNPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. FMN binding Source: InterPro
    2. long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity Source: UniProtKB-EC
    3. medium-chain-(S)-2-hydroxy-acid oxidase activity Source: UniProtKB-EC
    4. very-long-chain-(S)-2-hydroxy-acid oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. fatty acid oxidation Source: Ensembl

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Flavoprotein, FMN

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hydroxyacid oxidase 2 (EC:1.1.3.15)
    Short name:
    HAOX2
    Alternative name(s):
    (S)-2-hydroxy-acid oxidase, peroxisomal
    Gene namesi
    Name:HAO2
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 3

    Subcellular locationi

    Peroxisome By similarity

    GO - Cellular componenti

    1. mitochondrion Source: Ensembl
    2. peroxisome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 353352Hydroxyacid oxidase 2PRO_0000285088Add
    BLAST

    Proteomic databases

    PRIDEiQ3ZBW2.

    Interactioni

    Subunit structurei

    Homotetramer or homooctamer.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000000134.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3ZBW2.
    SMRiQ3ZBW2. Positions 2-350.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 353352FMN hydroxy acid dehydrogenasePROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi351 – 3533Microbody targeting signalSequence Analysis

    Sequence similaritiesi

    Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.PROSITE-ProRule annotation
    Contains 1 FMN hydroxy acid dehydrogenase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG1304.
    GeneTreeiENSGT00390000018717.
    HOGENOMiHOG000217463.
    HOVERGENiHBG051881.
    InParanoidiQ3ZBW2.
    KOiK11517.
    OMAiFREHARE.
    OrthoDBiEOG7B5WW0.
    TreeFamiTF313363.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR012133. Alpha-hydoxy_acid_DH_FMN.
    IPR000262. FMN-dep_DH.
    IPR008259. FMN_hydac_DH_AS.
    [Graphical view]
    PfamiPF01070. FMN_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000138. Al-hdrx_acd_dh. 1 hit.
    PROSITEiPS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
    PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q3ZBW2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPLVCLTDFR EHAREHLSKS TWDFIEGGAD DCCTRDENMA AFKKIRLRPR    50
    YLKDVSKVDM RTTIQGAEIS APICIAPTGF HRLAWPDGEM STARAAQAAS 100
    ICYITSTYAS CSLEDIVAAA PRGLRWFQLY VHPNRQINKQ MIQKVESLGF 150
    KALVITVDVP KVGNRRNDIT NQVDLMKKLL LKDLGSPEMG NVMPYFQMSP 200
    IDPSICWEDL SWFQSMTRLP IILKGILTKE DAELAVKHNV HGIIVSNHGG 250
    RQLDEVPASI DALTEVVAAV KGKVEVYLDG GIRTGNDVLK ALALGAKCVF 300
    VGRPILWGLA YKGEHGVKEV LDILKNEFHT SMTLTGCRSV AEINQDLIQF 350
    SRL 353
    Length:353
    Mass (Da):39,253
    Last modified:September 27, 2005 - v1
    Checksum:iE20D09034252F692
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC103070 mRNA. Translation: AAI03071.1.
    RefSeqiNP_001030243.1. NM_001035071.1.
    XP_005204069.1. XM_005204012.1.
    UniGeneiBt.46051.

    Genome annotation databases

    EnsembliENSBTAT00000000134; ENSBTAP00000000134; ENSBTAG00000000123.
    GeneIDi509481.
    KEGGibta:509481.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC103070 mRNA. Translation: AAI03071.1 .
    RefSeqi NP_001030243.1. NM_001035071.1.
    XP_005204069.1. XM_005204012.1.
    UniGenei Bt.46051.

    3D structure databases

    ProteinModelPortali Q3ZBW2.
    SMRi Q3ZBW2. Positions 2-350.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000000134.

    Proteomic databases

    PRIDEi Q3ZBW2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000000134 ; ENSBTAP00000000134 ; ENSBTAG00000000123 .
    GeneIDi 509481.
    KEGGi bta:509481.

    Organism-specific databases

    CTDi 51179.

    Phylogenomic databases

    eggNOGi COG1304.
    GeneTreei ENSGT00390000018717.
    HOGENOMi HOG000217463.
    HOVERGENi HBG051881.
    InParanoidi Q3ZBW2.
    KOi K11517.
    OMAi FREHARE.
    OrthoDBi EOG7B5WW0.
    TreeFami TF313363.

    Miscellaneous databases

    NextBioi 20868982.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR012133. Alpha-hydoxy_acid_DH_FMN.
    IPR000262. FMN-dep_DH.
    IPR008259. FMN_hydac_DH_AS.
    [Graphical view ]
    Pfami PF01070. FMN_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000138. Al-hdrx_acd_dh. 1 hit.
    PROSITEi PS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
    PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Fetal liver.

    Entry informationi

    Entry nameiHAOX2_BOVIN
    AccessioniPrimary (citable) accession number: Q3ZBW2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 2007
    Last sequence update: September 27, 2005
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3