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Protein

Hydroxyacid oxidase 2

Gene

HAO2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

(S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2.

Cofactori

FMNPROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei106 – 1061FMNPROSITE-ProRule annotation
Binding sitei128 – 1281FMNPROSITE-ProRule annotation
Binding sitei130 – 1301SubstratePROSITE-ProRule annotation
Binding sitei156 – 1561FMNPROSITE-ProRule annotation
Binding sitei165 – 1651SubstratePROSITE-ProRule annotation
Binding sitei224 – 2241FMNPROSITE-ProRule annotation
Active sitei248 – 2481Proton acceptorPROSITE-ProRule annotation
Binding sitei251 – 2511SubstratePROSITE-ProRule annotation
Binding sitei303 – 3031FMNPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi279 – 30325FMNPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Flavoprotein, FMN

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyacid oxidase 2 (EC:1.1.3.15)
Short name:
HAOX2
Alternative name(s):
(S)-2-hydroxy-acid oxidase, peroxisomal
Gene namesi
Name:HAO2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Chromosome 3

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 353352Hydroxyacid oxidase 2PRO_0000285088Add
BLAST

Proteomic databases

PRIDEiQ3ZBW2.

Interactioni

Subunit structurei

Homotetramer or homooctamer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000000134.

Structurei

3D structure databases

ProteinModelPortaliQ3ZBW2.
SMRiQ3ZBW2. Positions 2-350.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 353352FMN hydroxy acid dehydrogenasePROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi351 – 3533Microbody targeting signalSequence Analysis

Sequence similaritiesi

Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.PROSITE-ProRule annotation
Contains 1 FMN hydroxy acid dehydrogenase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG1304.
GeneTreeiENSGT00390000018717.
HOGENOMiHOG000217463.
HOVERGENiHBG051881.
InParanoidiQ3ZBW2.
KOiK11517.
OMAiFHRLAWP.
OrthoDBiEOG7B5WW0.
TreeFamiTF313363.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR012133. Alpha-hydoxy_acid_DH_FMN.
IPR000262. FMN-dep_DH.
IPR008259. FMN_hydac_DH_AS.
[Graphical view]
PfamiPF01070. FMN_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITEiPS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3ZBW2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLVCLTDFR EHAREHLSKS TWDFIEGGAD DCCTRDENMA AFKKIRLRPR
60 70 80 90 100
YLKDVSKVDM RTTIQGAEIS APICIAPTGF HRLAWPDGEM STARAAQAAS
110 120 130 140 150
ICYITSTYAS CSLEDIVAAA PRGLRWFQLY VHPNRQINKQ MIQKVESLGF
160 170 180 190 200
KALVITVDVP KVGNRRNDIT NQVDLMKKLL LKDLGSPEMG NVMPYFQMSP
210 220 230 240 250
IDPSICWEDL SWFQSMTRLP IILKGILTKE DAELAVKHNV HGIIVSNHGG
260 270 280 290 300
RQLDEVPASI DALTEVVAAV KGKVEVYLDG GIRTGNDVLK ALALGAKCVF
310 320 330 340 350
VGRPILWGLA YKGEHGVKEV LDILKNEFHT SMTLTGCRSV AEINQDLIQF

SRL
Length:353
Mass (Da):39,253
Last modified:September 27, 2005 - v1
Checksum:iE20D09034252F692
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103070 mRNA. Translation: AAI03071.1.
RefSeqiNP_001030243.1. NM_001035071.1.
XP_005204069.1. XM_005204012.2.
UniGeneiBt.46051.

Genome annotation databases

EnsembliENSBTAT00000000134; ENSBTAP00000000134; ENSBTAG00000000123.
GeneIDi509481.
KEGGibta:509481.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103070 mRNA. Translation: AAI03071.1.
RefSeqiNP_001030243.1. NM_001035071.1.
XP_005204069.1. XM_005204012.2.
UniGeneiBt.46051.

3D structure databases

ProteinModelPortaliQ3ZBW2.
SMRiQ3ZBW2. Positions 2-350.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000000134.

Proteomic databases

PRIDEiQ3ZBW2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000000134; ENSBTAP00000000134; ENSBTAG00000000123.
GeneIDi509481.
KEGGibta:509481.

Organism-specific databases

CTDi51179.

Phylogenomic databases

eggNOGiCOG1304.
GeneTreeiENSGT00390000018717.
HOGENOMiHOG000217463.
HOVERGENiHBG051881.
InParanoidiQ3ZBW2.
KOiK11517.
OMAiFHRLAWP.
OrthoDBiEOG7B5WW0.
TreeFamiTF313363.

Miscellaneous databases

NextBioi20868982.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR012133. Alpha-hydoxy_acid_DH_FMN.
IPR000262. FMN-dep_DH.
IPR008259. FMN_hydac_DH_AS.
[Graphical view]
PfamiPF01070. FMN_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITEiPS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal liver.

Entry informationi

Entry nameiHAOX2_BOVIN
AccessioniPrimary (citable) accession number: Q3ZBW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: September 27, 2005
Last modified: July 22, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.