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Q3ZBW2 (HAOX2_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Hydroxyacid oxidase 2
Short name=HAOX2
EC=1.1.3.15
Alternative name(s):
(S)-2-hydroxy-acid oxidase, peroxisomal
Gene names
Name:HAO2
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length353 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

(S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2.

Cofactor

FMN By similarity.

Subunit structure

Homotetramer or homooctamer By similarity.

Subcellular location

Peroxisome By similarity.

Sequence similarities

Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

Contains 1 FMN hydroxy acid dehydrogenase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 353352Hydroxyacid oxidase 2
PRO_0000285088

Regions

Domain1 – 353353FMN hydroxy acid dehydrogenase
Nucleotide binding279 – 30325FMN By similarity
Motif351 – 3533Microbody targeting signal Potential

Sites

Active site2481Proton acceptor By similarity
Binding site1061FMN By similarity
Binding site1281FMN By similarity
Binding site1301Substrate By similarity
Binding site1561FMN By similarity
Binding site1651Substrate By similarity
Binding site2241FMN By similarity
Binding site2511Substrate Potential
Binding site3031FMN By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3ZBW2 [UniParc].

Last modified September 27, 2005. Version 1.
Checksum: E20D09034252F692

FASTA35339,253
        10         20         30         40         50         60 
MPLVCLTDFR EHAREHLSKS TWDFIEGGAD DCCTRDENMA AFKKIRLRPR YLKDVSKVDM 

        70         80         90        100        110        120 
RTTIQGAEIS APICIAPTGF HRLAWPDGEM STARAAQAAS ICYITSTYAS CSLEDIVAAA 

       130        140        150        160        170        180 
PRGLRWFQLY VHPNRQINKQ MIQKVESLGF KALVITVDVP KVGNRRNDIT NQVDLMKKLL 

       190        200        210        220        230        240 
LKDLGSPEMG NVMPYFQMSP IDPSICWEDL SWFQSMTRLP IILKGILTKE DAELAVKHNV 

       250        260        270        280        290        300 
HGIIVSNHGG RQLDEVPASI DALTEVVAAV KGKVEVYLDG GIRTGNDVLK ALALGAKCVF 

       310        320        330        340        350 
VGRPILWGLA YKGEHGVKEV LDILKNEFHT SMTLTGCRSV AEINQDLIQF SRL

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Fetal liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC103070 mRNA. Translation: AAI03071.1.
IPIIPI00709789.
RefSeqNP_001030243.1. NM_001035071.1.
UniGeneBt.46051.

3D structure databases

HSSPHSSP built from PDB template 1FCB based on UniProtKB P00175.
ProteinModelPortalQ3ZBW2.
SMRQ3ZBW2. Positions 2-350.
ModBaseSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000000134.

Proteomic databases

PRIDEQ3ZBW2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000000134; ENSBTAP00000000134; ENSBTAG00000000123.
GeneID509481.
KEGGbta:509481.

Organism-specific databases

CTD51179.

Phylogenomic databases

eggNOGCOG1304.
GeneTreeENSGT00390000018717.
HOGENOMHOG000217463.
HOVERGENHBG051881.
InParanoidQ3ZBW2.
KOK11517.
OMAEGPEMSL.
OrthoDBEOG4QRH46.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR012133. Alpha-hydoxy_acid_DH_FMN.
IPR000262. FMN-dep_DH.
IPR008259. FMN_hydac_DH_AS.
[Graphical view]
PfamPF01070. FMN_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITEPS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20868982.

Entry information

Entry nameHAOX2_BOVIN
AccessionPrimary (citable) accession number: Q3ZBW2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: September 27, 2005
Last modified: April 3, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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