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Reviewed, UniProtKB/Swiss-Prot Q3ZBV8 (SYTC_BOVIN)

Last modified February 9, 2010. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Threonyl-tRNA synthetase, cytoplasmic
    EC=6.1.1.3
Alternative name(s):
    Threonine--tRNA ligase
      Short name=ThrRS
Gene names
Name: TARS
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length723 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Catalytic activity

ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   PTMAcetylation
Isopeptide bond
Phosphoprotein
Ubl conjugation
Gene Ontology (GO)
   Biological processthreonyl-tRNA aminoacylation

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

threonine-tRNA ligase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 723723Threonyl-tRNA synthetase, cytoplasmic
PRO_0000245024

Amino acid modifications

Modified residue2431N6-acetyllysine By similarity
Modified residue2981Phosphotyrosine By similarity
Cross-link222Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3ZBV8-1 [UniParc].

Last modified September 27, 2005. Version 1.
Checksum: 58CC4E5B7BDC4C85

FASTA72383,492
        10         20         30         40         50         60 
MSEEQASSPS AKMGDEEKPV GAGEEKQKEG SKKKNKEGSG DGGRAELNPW PEYINTRLEM 

        70         80         90        100        110        120 
YNKLKAEHDS ILAEKAEKDS KPIKVTLPDG KQVDAESWKT TPYQIACGIS QGLADNTVIA 

       130        140        150        160        170        180 
KVNKAVWDLD RPLEEDCTLE LLKFEDEEAQ AVYWHSSAHI MGEAMERVYG GCLCYGPPIE 

       190        200        210        220        230        240 
NGFYYDMYLE EGGVSSNDFS SLETLCKKII KEKQAFERLE VKKETLLEMF KYNKFKCRIL 

       250        260        270        280        290        300 
NEKVNTPTTT VYRCGPLIDL CRGPHVRHTG KIKTLKIHKN SSTYWEGKSD METLQRIYGI 

       310        320        330        340        350        360 
SFPDPKMLKE WEKFQEEAKN RDHRKIGRDQ ELYFFHELSP GSCFFLPKGA YIYNTLIEFI 

       370        380        390        400        410        420 
RSEYRKRGFQ EVVTPNIYNS RLWVTSGHWE HYSENMFSFE VEKELFALKP MNCPGHCLMF 

       430        440        450        460        470        480 
DHRPRSWREL PLRVADFGVL HRNELSGALT GLTRVRRFQQ DDAHIFCAME QIEDEIKGCL 

       490        500        510        520        530        540 
DFLRTVYSIF GFSFKLNLST RPEKFLGDIE VWNQAEKQLE NSLNDFGEKW ELNPGDGAFY 

       550        560        570        580        590        600 
GPKIDIQIKD AIGRYHQCAT IQLDFQLPIR FNLTFVSHDG DDKKKPVIIH RAILGSVERM 

       610        620        630        640        650        660 
IAILTENYGG KWPFWLSPRQ VMVVPVGPTC DEYAQKVRQQ FHNAKFMVDI DLDPGCTLNK 

       670        680        690        700        710        720 
KIRNAQLAQY NFILVVGEKE KTSGTVNIRT RDNKVHGERT ISETIERLQQ LKHSRSKQAE 


EEF 

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References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Ileum.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC103082 mRNA. Translation: AAI03083.1.
IPIIPI00711455.
RefSeqNP_001029542.1.
UniGeneBt.49332

3D structure databases

SMRQ3ZBV8. Positions 81-153, 83-714, 321-721.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ3ZBV8.

Proteomic databases

PRIDEQ3ZBV8.

Genome annotation databases

EnsemblENSBTAT00000018947; ENSBTAP00000018947; ENSBTAG00000014261; Bos taurus. [Genome view]
GeneID510075.
KEGGbta:510075.

Organism-specific databases

CTD510075.

Phylogenomic databases

eggNOGmaNOG11622.
HOVERGENQ3ZBV8.
InParanoidQ3ZBV8.
OMAHGARIYN.
OrthoDBEOG92JR9S.
PhylomeDBQ3ZBV8.

Enzyme and pathway databases

BRENDA6.1.1.3. 251.

Family and domain databases

InterProIPR002314. aa-tRNA-synt_IIb_cons-dom.
IPR006195. aa-tRNA-synth_II_cons-dom.
IPR004154. Anticodon_bd.
IPR012675. b-grasp_ferredoxin-like.
IPR004095. TGS.
IPR012676. TGS-like.
IPR002320. Thr-tRNA-synth_IIa.
IPR018158. Thr-tRNA-synth_IIa_cons-reg.
IPR018163. Thr/Ala-tRNA-synth_IIc_edit.
IPR012947. tRNA_SAD.
[Graphical view]
Gene3DG3DSA:3.40.50.800. Anticodon_bd. 1 hit.
G3DSA:3.10.20.30. Ferredoxin_fold. 1 hit.
PfamPF03129. HGTP_anticodon. 1 hit.
PF02824. TGS. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
PF07973. tRNA_SAD. 1 hit.
[Graphical view]
PRINTSPR01047. TRNASYNTHTHR.
SMARTSM00863. tRNA_SAD. 1 hit.
[Graphical view]
TIGRFAMsTIGR00418. thrS. 1 hit.
PROSITEPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYTC_BOVIN
AccessionPrimary (citable) accession number: Q3ZBV8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: September 27, 2005
Last modified: February 9, 2010
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents