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Protein

F-box only protein 9

Gene

FBXO9

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1 (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-BTA-983168. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 9
Gene namesi
Name:FBXO9
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componentsi: Chromosome 23, Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002599561 – 437F-box only protein 9Add BLAST437

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei126PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ3ZBT2.
PRIDEiQ3ZBT2.

Expressioni

Gene expression databases

BgeeiENSBTAG00000015083.

Interactioni

Subunit structurei

Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO9) composed of CUL1, SKP1, RBX1 and FBXO9. Interacts with TTI1 and TELO2; when TTI1 and TELO2 are phosphorylated by CK2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020074.

Structurei

3D structure databases

ProteinModelPortaliQ3ZBT2.
SMRiQ3ZBT2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati84 – 117TPRAdd BLAST34
Domaini175 – 226F-boxPROSITE-ProRule annotationAdd BLAST52

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation
Contains 1 TPR repeat.Curated

Keywords - Domaini

TPR repeat

Phylogenomic databases

eggNOGiKOG2997. Eukaryota.
ENOG410XPVI. LUCA.
GeneTreeiENSGT00390000014256.
HOGENOMiHOG000047162.
HOVERGENiHBG001041.
InParanoidiQ3ZBT2.
KOiK10295.
OMAiLVWIHHS.
OrthoDBiEOG091G0BDF.
TreeFamiTF324797.

Family and domain databases

Gene3Di1.20.58.280. 1 hit.
InterProiIPR001810. F-box_dom.
IPR007330. MIT.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SUPFAMiSSF116846. SSF116846. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3ZBT2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEAEEDCHS EAVREGDDDD ENESPAETDL QAQLQRFRAQ WMFELAPGGG
60 70 80 90 100
SGNLESRPCR AARGSLLRAA DTRGKQELAK EEKARELFLK AVEEEQNGAL
110 120 130 140 150
YEAIKFYRRA MQLVPDIEFK ITYTRSPDGD GVGNSYIEDT DDDSKMADLL
160 170 180 190 200
SYFQQQLTFQ ESVLKLCQPE LESSQTHISA LPMEVLMYVF RWVVSSDLDL
210 220 230 240 250
RSLEQLSQVC RGFYICARDP EIWRLACLKV WGRSCIKLVP YTSWREMFLE
260 270 280 290 300
RPRVRFDGVY ISKTTYIRQG EQSLDGFYRA WHQVEYYRYV RFFPDGHVMM
310 320 330 340 350
LTTPEEPQSI VPRLRTRNTR TDAILLGHYR LSQDTDNQTK VFAVITKKKE
360 370 380 390 400
EKALDHKYRY FRRAPVQEAD QNFHVGLQLC SSGHQSFNKL IWIHHSCHIT
410 420 430
YKSTGETAVT AFEIDKMYTP LLFARVRSYT AFSERPL
Length:437
Mass (Da):50,817
Last modified:March 6, 2013 - v2
Checksum:iC4D85EB424BC0661
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti189V → I in AAI03125 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02055275 Genomic DNA. No translation available.
BC103124 mRNA. Translation: AAI03125.1.
RefSeqiNP_001029584.1. NM_001034412.2.
UniGeneiBt.49317.

Genome annotation databases

EnsembliENSBTAT00000020074; ENSBTAP00000020074; ENSBTAG00000015083.
GeneIDi511798.
KEGGibta:511798.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02055275 Genomic DNA. No translation available.
BC103124 mRNA. Translation: AAI03125.1.
RefSeqiNP_001029584.1. NM_001034412.2.
UniGeneiBt.49317.

3D structure databases

ProteinModelPortaliQ3ZBT2.
SMRiQ3ZBT2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020074.

Proteomic databases

PaxDbiQ3ZBT2.
PRIDEiQ3ZBT2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000020074; ENSBTAP00000020074; ENSBTAG00000015083.
GeneIDi511798.
KEGGibta:511798.

Organism-specific databases

CTDi26268.

Phylogenomic databases

eggNOGiKOG2997. Eukaryota.
ENOG410XPVI. LUCA.
GeneTreeiENSGT00390000014256.
HOGENOMiHOG000047162.
HOVERGENiHBG001041.
InParanoidiQ3ZBT2.
KOiK10295.
OMAiLVWIHHS.
OrthoDBiEOG091G0BDF.
TreeFamiTF324797.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiR-BTA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Gene expression databases

BgeeiENSBTAG00000015083.

Family and domain databases

Gene3Di1.20.58.280. 1 hit.
InterProiIPR001810. F-box_dom.
IPR007330. MIT.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SUPFAMiSSF116846. SSF116846. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFBX9_BOVIN
AccessioniPrimary (citable) accession number: Q3ZBT2
Secondary accession number(s): F1MVQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 14, 2006
Last sequence update: March 6, 2013
Last modified: November 2, 2016
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.