Q3ZBM7 (TRPT1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
tRNA 2'-phosphotransferase 1
EC=2.7.1.160

Gene names

Name:

TRPT1

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	254 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate By similarity.
Catalytic activity	2'-phospho-[ligated tRNA] + NAD+ = mature tRNA + ADP ribose 1'',2''-phosphate + nicotinamide + H2O.
Sequence similarities	Belongs to the KptA/TPT1 family.
Sequence caution	The sequence AAI03211.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	tRNA processing
Ligand	NAD
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	tRNA splicing, via endonucleolytic cleavage and ligation Inferred from electronic annotation. Source: InterPro
Molecular_function	tRNA 2'-phosphotransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 254	254	tRNA 2'-phosphotransferase 1		PRO_0000273362

Sequences

	Sequence		Length	Mass (Da)
	Q3ZBM7 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: F18DA8315C9F2820	FASTA	254	27,791
	10 20 30 40 50 60 MNSFGGRRRE TAGPKGRRAH RPPQDQDRDV QLSKALSYAL RHGALKLGLP MGADGFVPLD 70 80 90 100 110 120 ALLQLPQFRS FSAEDVQRVV DTNVKQRFAL QPGDPSTGPL IRANQGHSLQ VPELELEPLE 130 140 150 160 170 180 TPQALPLMLV HGTFRQHWPS ILLKGLSCRG RTHIHLAPGL PGDPGVISGM RPNCEVAVFI 190 200 210 220 230 240 NGPLALADGI PFFRSTNGVI LTPGNADGVL PPKYFKEALQ LRPTRKPLSL AGNEEKEHQR 250 DSKHSSRGRG MTQQ

References

[1]	"Characterization of 954 bovine full-CDS cDNA sequences." Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L. BMC Genomics 6:166-166(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 27-254. Strain: Hereford. Tissue: Hypothalamus.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DN524407 mRNA. No translation available. BC103210 mRNA. Translation: AAI03211.2. Different initiation.
IPI	IPI00712837.
UniGene	Bt.101877.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	9913.ENSBTAP00000022022.
Proteomic databases
PRIDE	Q3ZBM7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
eggNOG	COG1859.
HOGENOM	HOG000229875.
HOVERGEN	HBG092612.
InParanoid	Q3ZBM7.
OrthoDB	EOG44F6BB.
Family and domain databases
InterPro	IPR002745. Ptrans_KptA/Tpt1. [Graphical view]
Pfam	PF01885. PTS_2-RNA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPT1_BOVIN

Accession

Primary (citable) accession number: Q3ZBM7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2007
Last sequence update:	January 23, 2007
Last modified:	May 29, 2013
This is version 57 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program