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Protein

Cyclin-H

Gene

CCNH

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-H
Gene namesi
Name:CCNH
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 320320Cyclin-HPRO_0000282332Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei5 – 51Phosphoserine; by CDK8By similarity
Modified residuei132 – 1321PhosphoserineBy similarity
Modified residuei304 – 3041Phosphoserine; by CDK8By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ3ZBL9.
PRIDEiQ3ZBL9.

Interactioni

Subunit structurei

Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000034897.

Structurei

3D structure databases

ProteinModelPortaliQ3ZBL9.
SMRiQ3ZBL9. Positions 11-287.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin C subfamily.Curated

Phylogenomic databases

eggNOGiKOG2496. Eukaryota.
COG5333. LUCA.
HOGENOMiHOG000232149.
HOVERGENiHBG050840.
InParanoidiQ3ZBL9.
KOiK06634.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR031658. Cyclin_C_2.
IPR006671. Cyclin_N.
IPR027081. CyclinH/Ccl1.
[Graphical view]
PfamiPF16899. Cyclin_C_2. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
TIGRFAMsiTIGR00569. ccl1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3ZBL9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYHNSSQKRH WTFASEEQLA RLRADANRKF KCKAVANGKV LPNDPVFLEP
60 70 80 90 100
HEEITLCKYY EKRLLEFCSV FKPAMPRSVV GTACMYFKRF YLNNSVMEYH
110 120 130 140 150
PRIIMLTCAF LACKVDEFNV SSPQFVGNLR ESPLGQEKTL EQILEYELLL
160 170 180 190 200
IQQLNFHLIV HNPYRPFEGF LIDLKTRYPL LENPEILRKT ADDFLNRVAL
210 220 230 240 250
TDAHLLYTPS QIALTAILSS ASRAGITMES YLSESLMLKE NRTSLSQLLD
260 270 280 290 300
IMKSMRNLVK KYEPPRPEEV AALKQKLERC HSAELALNVV TKKRKGYEDD
310 320
DYVSKKSKHE EVCSPKGSFM
Length:320
Mass (Da):37,028
Last modified:September 27, 2005 - v1
Checksum:iA46D122811F65AFF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103224 mRNA. Translation: AAI03225.1.
RefSeqiNP_001073256.1. NM_001079788.2.
UniGeneiBt.177.

Genome annotation databases

GeneIDi615512.
KEGGibta:615512.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103224 mRNA. Translation: AAI03225.1.
RefSeqiNP_001073256.1. NM_001079788.2.
UniGeneiBt.177.

3D structure databases

ProteinModelPortaliQ3ZBL9.
SMRiQ3ZBL9. Positions 11-287.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000034897.

Proteomic databases

PaxDbiQ3ZBL9.
PRIDEiQ3ZBL9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi615512.
KEGGibta:615512.

Organism-specific databases

CTDi902.

Phylogenomic databases

eggNOGiKOG2496. Eukaryota.
COG5333. LUCA.
HOGENOMiHOG000232149.
HOVERGENiHBG050840.
InParanoidiQ3ZBL9.
KOiK06634.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR031658. Cyclin_C_2.
IPR006671. Cyclin_N.
IPR027081. CyclinH/Ccl1.
[Graphical view]
PfamiPF16899. Cyclin_C_2. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
TIGRFAMsiTIGR00569. ccl1. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Heart ventricle.

Entry informationi

Entry nameiCCNH_BOVIN
AccessioniPrimary (citable) accession number: Q3ZBL9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: September 27, 2005
Last modified: June 8, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.