ID   PTH2_BOVIN              Reviewed;         179 AA.
AC   Q3ZBL5; Q05KI4; Q5BIN3;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   16-JUN-2009, entry version 28.
DE   RecName: Full=Peptidyl-tRNA hydrolase 2, mitochondrial;
DE            Short=PTH 2;
DE            EC=3.1.1.29;
DE   AltName: Full=Bcl-2 inhibitor of transcription;
DE   Flags: Precursor;
GN   Name=PTRH2; Synonyms=BIT1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Placenta;
RA   Ushizawa K., Takahashi T., Hosoe M., Hashizume K.;
RT   "Expression of Bcl-2 family in bovine placenta.";
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Heart ventricle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The natural substrate for this enzyme may be peptidyl-
CC       tRNAs which drop off the ribosome during protein synthesis (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: N-substituted aminoacyl-tRNA + H(2)O = N-
CC       substituted amino acid + tRNA.
CC   -!- SUBUNIT: Monomer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion (By similarity).
CC   -!- SIMILARITY: Belongs to the PTH2 family.
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DR   EMBL; AB238942; BAF35578.1; -; mRNA.
DR   EMBL; BT021191; AAX31373.1; -; mRNA.
DR   EMBL; BC103230; AAI03231.1; -; mRNA.
DR   IPI; IPI00694334; -.
DR   RefSeq; NP_001029691.1; -.
DR   UniGene; Bt.13767; -.
DR   SMR; Q3ZBL5; 63-179.
DR   Ensembl; ENSBTAG00000016710; Bos taurus.
DR   GeneID; 516595; -.
DR   KEGG; bta:516595; -.
DR   HOVERGEN; Q3ZBL5; -.
DR   OMA; Q3ZBL5; IQRRNPE.
DR   BRENDA; 3.1.1.29; 251.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0004045; F:aminoacyl-tRNA hydrolase activity; IEA:EC.
DR   GO; GO:0006412; P:translation; IEA:InterPro.
DR   InterPro; IPR002833; Pep_tRNA_hydro_PTH2.
DR   Pfam; PF01981; PTH2; 1.
DR   ProDom; PD010667; UPF0099; 1.
DR   TIGRFAMs; TIGR00283; Pep_tRNA_hydro_PTH2; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase; Mitochondrion; Phosphoprotein; Transit peptide.
FT   TRANSIT       1     62       Mitochondrion (Potential).
FT   CHAIN        63    179       Peptidyl-tRNA hydrolase 2, mitochondrial.
FT                                /FTId=PRO_0000240443.
FT   MOD_RES      57     57       Phosphoserine (By similarity).
FT   CONFLICT     20     20       A -> V (in Ref. 2; AAX31373).
SQ   SEQUENCE   179 AA;  19291 MW;  8FC2E82B73B7BC02 CRC64;
     MISRSLVMEY LTNPGALSLA AGVACGVCLG WGLRMRFGML PKSSVRETNP DTETEASILG
     ESGEYKMILV VRNDLKMGKG KVAAQCSHAA VSAYKQIQRR NPELLKEWEY CGQPKVVVKA
     PDEETLVELL THAKVLGLTV SLIQDAGRTQ IAPGSRTVLG IGPGPADLID KVTGHLKLY
//