Reviewed, UniProtKB/Swiss-Prot Q3ZBL5 (PTH2_BOVIN)

Names and origin

Protein names

Recommended name:
    Peptidyl-tRNA hydrolase 2, mitochondrial
      Short name=PTH 2
    EC=3.1.1.29
Alternative name(s):
    Bcl-2 inhibitor of transcription

Gene names

Name:	PTRH2
Synonyms:	BIT1

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	179 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis By similarity.
Catalytic activity	N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA.
Subunit structure	Monomer By similarity.
Subcellular location	Mitochondrion By similarity.
Sequence similarities	Belongs to the PTH2 family.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Molecular function	Hydrolase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	translation Inferred from electronic annotation. Source: InterPro
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	aminoacyl-tRNA hydrolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 62	62	Mitochondrion Potential
	Chain	63 – 179	117	Peptidyl-tRNA hydrolase 2, mitochondrial		PRO_0000240443
Amino acid modifications
	Modified residue	57	1	Phosphoserine By similarity
Experimental info
	Sequence conflict	20	1	A → V in AAX31373. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q3ZBL5-1 [UniParc]. Last modified September 27, 2005. Version 1. Checksum: 8FC2E82B73B7BC02	FASTA	179	19,291
	10 20 30 40 50 60 MISRSLVMEY LTNPGALSLA AGVACGVCLG WGLRMRFGML PKSSVRETNP DTETEASILG 70 80 90 100 110 120 ESGEYKMILV VRNDLKMGKG KVAAQCSHAA VSAYKQIQRR NPELLKEWEY CGQPKVVVKA 130 140 150 160 170 PDEETLVELL THAKVLGLTV SLIQDAGRTQ IAPGSRTVLG IGPGPADLID KVTGHLKLY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression of Bcl-2 family in bovine placenta." Ushizawa K., Takahashi T., Hosoe M., Hashizume K. Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta.
[2]	"Characterization of 954 bovine full-CDS cDNA sequences." Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L. BMC Genomics 6:166-166(2005) [PubMed: 16305752] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Heart ventricle.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB238942 mRNA. Translation: BAF35578.1. BT021191 mRNA. Translation: AAX31373.1. BC103230 mRNA. Translation: AAI03231.1.
IPI	IPI00694334.
RefSeq	NP_001029691.1.
UniGene	Bt.13767
3D structure databases
SMR	Q3ZBL5. Positions 63-179.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3ZBL5.
Genome annotation databases
Ensembl	ENSBTAT00000022212; ENSBTAP00000022212; ENSBTAG00000016710; Bos taurus. [Genome view]
GeneID	516595.
KEGG	bta:516595.
Organism-specific databases
CTD	516595.
Phylogenomic databases
HOVERGEN	Q3ZBL5.
OMA	IQRRNPE.
Enzyme and pathway databases
BRENDA	3.1.1.29. 251.
Family and domain databases
InterPro	IPR002833. Pep_tRNA_hydro_PTH2. [Graphical view]
Pfam	PF01981. PTH2. 1 hit. [Graphical view]
ProDom	PD010667. UPF0099. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00283. Pep_tRNA_hydro_PTH2. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PTH2_BOVIN

Accession

Primary (citable) accession number: Q3ZBL5
Secondary accession number(s): Q05KI4, Q5BIN3

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	September 27, 2005
Last modified:	November 3, 2009
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)