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Protein

Peptidyl-tRNA hydrolase 2, mitochondrial

Gene

PTRH2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.By similarity

Catalytic activityi

N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA.

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-tRNA hydrolase 2, mitochondrial (EC:3.1.1.29)
Short name:
PTH 2
Alternative name(s):
Bcl-2 inhibitor of transcription
Gene namesi
Name:PTRH2
Synonyms:BIT1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 62MitochondrionSequence analysisAdd BLAST62
ChainiPRO_000024044363 – 179Peptidyl-tRNA hydrolase 2, mitochondrialAdd BLAST117

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki76Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki81Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki95Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki106Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki115Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki171Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki177Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Post-translational modificationi

Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ3ZBL5.
PeptideAtlasiQ3ZBL5.
PRIDEiQ3ZBL5.

Expressioni

Gene expression databases

BgeeiENSBTAG00000016710.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022212.

Structurei

3D structure databases

ProteinModelPortaliQ3ZBL5.
SMRiQ3ZBL5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PTH2 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3282. Eukaryota.
COG1990. LUCA.
GeneTreeiENSGT00390000015991.
HOGENOMiHOG000227349.
HOVERGENiHBG049458.
InParanoidiQ3ZBL5.
KOiK04794.
OMAiKQVIVVR.
OrthoDBiEOG091G0WC2.
TreeFamiTF324583.

Family and domain databases

CDDicd02430. PTH2. 1 hit.
Gene3Di3.40.1490.10. 1 hit.
InterProiView protein in InterPro
IPR023476. Pep_tRNA_hydro_II_dom_sf.
IPR002833. PTH2.
PfamiView protein in Pfam
PF01981. PTH2. 1 hit.
SUPFAMiSSF102462. SSF102462. 1 hit.
TIGRFAMsiTIGR00283. arch_pth2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3ZBL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISRSLVMEY LTNPGALSLA AGVACGVCLG WGLRMRFGML PKSSVRETNP
60 70 80 90 100
DTETEASILG ESGEYKMILV VRNDLKMGKG KVAAQCSHAA VSAYKQIQRR
110 120 130 140 150
NPELLKEWEY CGQPKVVVKA PDEETLVELL THAKVLGLTV SLIQDAGRTQ
160 170
IAPGSRTVLG IGPGPADLID KVTGHLKLY
Length:179
Mass (Da):19,291
Last modified:September 27, 2005 - v1
Checksum:i8FC2E82B73B7BC02
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti20A → V in AAX31373 (PubMed:16305752).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB238942 mRNA. Translation: BAF35578.1.
BT021191 mRNA. Translation: AAX31373.1.
BC103230 mRNA. Translation: AAI03231.1.
RefSeqiNP_001029691.1. NM_001034519.1.
XP_005219951.1. XM_005219894.3.
UniGeneiBt.13767.

Genome annotation databases

EnsembliENSBTAT00000022212; ENSBTAP00000022212; ENSBTAG00000016710.
GeneIDi516595.
KEGGibta:516595.

Similar proteinsi

Entry informationi

Entry nameiPTH2_BOVIN
AccessioniPrimary (citable) accession number: Q3ZBL5
Secondary accession number(s): Q05KI4, Q5BIN3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: September 27, 2005
Last modified: November 22, 2017
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families