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Protein

Nucleoporin GLE1

Gene

GLE1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA transport, Protein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoporin GLE1
Alternative name(s):
GLE1-like protein
Gene namesi
Name:GLE1
Synonyms:GLE1L
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 11

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity
  • Nucleusnuclear pore complex By similarity

  • Note: Shuttles between the nucleus and the cytoplasm. Shuttling is essential for its mRNA export function.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002048211 – 698Nucleoporin GLE1Add BLAST698

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei41PhosphoserineBy similarity1
Modified residuei88PhosphoserineBy similarity1
Modified residuei99PhosphoserineBy similarity1
Modified residuei351PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ3ZBK7.
PRIDEiQ3ZBK7.

Expressioni

Gene expression databases

BgeeiENSBTAG00000030566.

Interactioni

Subunit structurei

Associated with the NPC, it however may not be a stable component of the NPC complex since it shuttles between the nucleus and the cytoplasm. Interacts with nuclear pore complex proteins NUP155 and NUPL2 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020333.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 29Interaction with NUP155By similarityAdd BLAST29
Regioni444 – 483Mediates the shuttling between the nucleus and the cytoplasmBy similarityAdd BLAST40
Regioni656 – 698Interaction with NUPL2By similarityAdd BLAST43

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili185 – 246Sequence analysisAdd BLAST62
Coiled coili308 – 356Sequence analysisAdd BLAST49

Sequence similaritiesi

Belongs to the GLE1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2412. Eukaryota.
ENOG410XT57. LUCA.
GeneTreeiENSGT00390000012903.
HOGENOMiHOG000246966.
HOVERGENiHBG081558.
InParanoidiQ3ZBK7.
KOiK18723.
OMAiGNQLCSQ.
OrthoDBiEOG091G0AZV.
TreeFamiTF324158.

Family and domain databases

InterProiIPR012476. GLE1.
[Graphical view]
PANTHERiPTHR12960. PTHR12960. 1 hit.
PfamiPF07817. GLE1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3ZBK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSEGRCWET LQALRSCDKG RLCYDRDWLL RGEDVLQECM SLPKLSSYSG
60 70 80 90 100
WVVDHVLPHI QKNAPPSETS ASSVSTSALD QPSSVPRSPL RNPAYSPVSS
110 120 130 140 150
ATSNGTKDKY ESPHTEPVVL QSPRGMKVEG CIRMYELVHR MKGAEGLRQW
160 170 180 190 200
QEEQEKKVRA LSEMASEQLK RFDERKELKH HKEFQDLREV MEKSSREALG
210 220 230 240 250
QQEKLKAEHR HRAKILNLKL REAEQQRLKQ EEQERLRKEE GQARLRGLYA
260 270 280 290 300
LQEEVLHLSQ QLDASDQHRD LLQVDLSAFR TRGNQLCSLV SGIIRATSEN
310 320 330 340 350
GFPTVEDQAA AEGALQEMRD LLSNLHQEIR RACEEKRRRD EEEARIKQQE
360 370 380 390 400
SQMQQRPEAH KELPVPNQGP GAKPNEDLQM KVQDSTMQWY QQLQEASSRC
410 420 430 440 450
VLAFEGLSNS KDSQAKKIKM DLQKAATIPV SQISTIAGSK LKEIFDKIHS
460 470 480 490 500
LLSGKPVQSG GRSVSVTLNP QGLDFVQYKL AEKFVKQGEE EVASHHEAAF
510 520 530 540 550
PIAVVASGIW ELHPRVGALI LAHLHKKCPY SVPFYPAFKE GMALEDYQRM
560 570 580 590 600
LGYQVKDSKV EQQDNFLKRM SGMIRLYAAI IQLRWPYGNR QETHPHGLNH
610 620 630 640 650
GWRWLAQILN MEPLSDVTAT LLFDFLEVCG NALMKQYQVQ FWKMILLIKE
660 670 680 690
DYFPRIEAIT SSGQMGSFIR LKQFLEKCLQ HREVPVPKGF LTASFWRS
Length:698
Mass (Da):79,954
Last modified:September 27, 2005 - v1
Checksum:i491613D115A36013
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103239 mRNA. Translation: AAI03240.1.
RefSeqiNP_001029890.1. NM_001034718.2.
UniGeneiBt.49512.

Genome annotation databases

EnsembliENSBTAT00000020333; ENSBTAP00000020333; ENSBTAG00000030566.
GeneIDi540982.
KEGGibta:540982.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103239 mRNA. Translation: AAI03240.1.
RefSeqiNP_001029890.1. NM_001034718.2.
UniGeneiBt.49512.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020333.

Proteomic databases

PaxDbiQ3ZBK7.
PRIDEiQ3ZBK7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000020333; ENSBTAP00000020333; ENSBTAG00000030566.
GeneIDi540982.
KEGGibta:540982.

Organism-specific databases

CTDi2733.

Phylogenomic databases

eggNOGiKOG2412. Eukaryota.
ENOG410XT57. LUCA.
GeneTreeiENSGT00390000012903.
HOGENOMiHOG000246966.
HOVERGENiHBG081558.
InParanoidiQ3ZBK7.
KOiK18723.
OMAiGNQLCSQ.
OrthoDBiEOG091G0AZV.
TreeFamiTF324158.

Gene expression databases

BgeeiENSBTAG00000030566.

Family and domain databases

InterProiIPR012476. GLE1.
[Graphical view]
PANTHERiPTHR12960. PTHR12960. 1 hit.
PfamiPF07817. GLE1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLE1_BOVIN
AccessioniPrimary (citable) accession number: Q3ZBK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: September 27, 2005
Last modified: September 7, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.