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Protein

U6 snRNA-associated Sm-like protein LSm4

Gene

LSM4

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds specifically to the 3'-terminal U-tract of U6 snRNA.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-BTA-430039. mRNA decay by 5' to 3' exoribonuclease.
R-BTA-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
U6 snRNA-associated Sm-like protein LSm4
Gene namesi
Name:LSM4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 139139U6 snRNA-associated Sm-like protein LSm4PRO_0000244620Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ3ZBK6.
PRIDEiQ3ZBK6.

Interactioni

Subunit structurei

LSm subunits form a heteromer with a doughnut shape.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000011312.

Structurei

3D structure databases

ProteinModelPortaliQ3ZBK6.
SMRiQ3ZBK6. Positions 14-71.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the snRNP Sm proteins family.Curated

Phylogenomic databases

eggNOGiKOG3293. Eukaryota.
ENOG4111TZU. LUCA.
GeneTreeiENSGT00610000086173.
HOGENOMiHOG000182713.
HOVERGENiHBG000486.
InParanoidiQ3ZBK6.
KOiK12623.
OMAiFKMSEAY.
OrthoDBiEOG747PMG.
TreeFamiTF315027.

Family and domain databases

InterProiIPR027141. LSm4/Sm_D1/D3.
IPR010920. LSM_dom.
IPR001163. LSM_dom_euk/arc.
[Graphical view]
PANTHERiPTHR23338. PTHR23338. 1 hit.
PfamiPF01423. LSM. 1 hit.
[Graphical view]
SMARTiSM00651. Sm. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3ZBK6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPLSLLKTA QNHPMLVELK NGETYNGHLV SCDNWMNINL REVICTSRDG
60 70 80 90 100
DKFWRMPECY IRGSTIKYLR IPDEIIDMVK EEVVAKGRGR GGLQQQKQQK
110 120 130
GRGMGGAGRG VFGGRGRGGI PGTGRGQPEK KPGRQAGKQ
Length:139
Mass (Da):15,350
Last modified:September 27, 2005 - v1
Checksum:iBCEFB20247335A1B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103243 mRNA. Translation: AAI03244.1.
RefSeqiNP_001030513.1. NM_001035436.2.
UniGeneiBt.49560.

Genome annotation databases

EnsembliENSBTAT00000011312; ENSBTAP00000011312; ENSBTAG00000008578.
GeneIDi613634.
KEGGibta:613634.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103243 mRNA. Translation: AAI03244.1.
RefSeqiNP_001030513.1. NM_001035436.2.
UniGeneiBt.49560.

3D structure databases

ProteinModelPortaliQ3ZBK6.
SMRiQ3ZBK6. Positions 14-71.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000011312.

Proteomic databases

PaxDbiQ3ZBK6.
PRIDEiQ3ZBK6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000011312; ENSBTAP00000011312; ENSBTAG00000008578.
GeneIDi613634.
KEGGibta:613634.

Organism-specific databases

CTDi25804.

Phylogenomic databases

eggNOGiKOG3293. Eukaryota.
ENOG4111TZU. LUCA.
GeneTreeiENSGT00610000086173.
HOGENOMiHOG000182713.
HOVERGENiHBG000486.
InParanoidiQ3ZBK6.
KOiK12623.
OMAiFKMSEAY.
OrthoDBiEOG747PMG.
TreeFamiTF315027.

Enzyme and pathway databases

ReactomeiR-BTA-430039. mRNA decay by 5' to 3' exoribonuclease.
R-BTA-72163. mRNA Splicing - Major Pathway.

Family and domain databases

InterProiIPR027141. LSm4/Sm_D1/D3.
IPR010920. LSM_dom.
IPR001163. LSM_dom_euk/arc.
[Graphical view]
PANTHERiPTHR23338. PTHR23338. 1 hit.
PfamiPF01423. LSM. 1 hit.
[Graphical view]
SMARTiSM00651. Sm. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Thymus.

Entry informationi

Entry nameiLSM4_BOVIN
AccessioniPrimary (citable) accession number: Q3ZBK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: September 27, 2005
Last modified: June 8, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.