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Protein

Ribonuclease H2 subunit B

Gene

RNASEH2B

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease H2 subunit B
Short name:
RNase H2 subunit B
Alternative name(s):
Ribonuclease HI subunit B
Gene namesi
Name:RNASEH2B
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 12

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 309308Ribonuclease H2 subunit BPRO_0000248377Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei295 – 2951N6-acetyllysineBy similarity
Modified residuei296 – 2961PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ3ZBI3.
PRIDEiQ3ZBI3.

Expressioni

Gene expression databases

BgeeiENSBTAG00000020149.

Interactioni

Subunit structurei

The RNase H2 complex is a heterotrimer composed of the catalytic subunit RNASEH2A and the non-catalytic subunits RNASEH2B and RNASEH2C.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000026838.

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase H2 subunit B family.Curated

Phylogenomic databases

eggNOGiKOG4705. Eukaryota.
ENOG410YS7I. LUCA.
GeneTreeiENSGT00390000011439.
HOGENOMiHOG000006910.
HOVERGENiHBG056010.
InParanoidiQ3ZBI3.
KOiK10744.
OMAiGARQHVF.
OrthoDBiEOG091G0M4Q.
TreeFamiTF105250.

Family and domain databases

CDDicd09270. RNase_H2-B. 1 hit.
InterProiIPR019024. RNase_H2_suB.
[Graphical view]
PfamiPF09468. RNase_H2-Ydr279. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3ZBI3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARGADGGDG ASVWQHVFLL PEYLKDDSKK MKSGLVFVKL ANPCSGEGTI
60 70 80 90 100
YLFNMCLPQL FEIKVFKEKN HSWFINESVQ SGGLLHFATP VDPLFLLLHY
110 120 130 140 150
LIKADKESFQ GKFQPLDQVV MDDMFPDCIL LLKLPELEKL LQHVTEEKEV
160 170 180 190 200
DKKKYYKYSK EKTLKWLGKK VNQTMAALKT NKVNVSARVQ STAFFSGGQV
210 220 230 240 250
SSDKDEDYVR YAHGLISDYI PKQLSDDLSK YLKLPEPPAS VRNPPSKKAK
260 270 280 290 300
LSDEPVMAKE DYTKFNSKDF KTVKKNSKMT AAQKALAKVD KSGMKSIDSF

FGTKHVKKK
Length:309
Mass (Da):35,008
Last modified:September 5, 2006 - v2
Checksum:i3B31765CBFDD6B8F
GO

Sequence cautioni

The sequence AAI03281 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103280 mRNA. Translation: AAI03281.1. Different initiation.
RefSeqiNP_001160038.1. NM_001166566.1.
UniGeneiBt.91620.

Genome annotation databases

EnsembliENSBTAT00000026838; ENSBTAP00000026838; ENSBTAG00000020149.
GeneIDi509258.
KEGGibta:509258.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103280 mRNA. Translation: AAI03281.1. Different initiation.
RefSeqiNP_001160038.1. NM_001166566.1.
UniGeneiBt.91620.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000026838.

Proteomic databases

PaxDbiQ3ZBI3.
PRIDEiQ3ZBI3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000026838; ENSBTAP00000026838; ENSBTAG00000020149.
GeneIDi509258.
KEGGibta:509258.

Organism-specific databases

CTDi79621.

Phylogenomic databases

eggNOGiKOG4705. Eukaryota.
ENOG410YS7I. LUCA.
GeneTreeiENSGT00390000011439.
HOGENOMiHOG000006910.
HOVERGENiHBG056010.
InParanoidiQ3ZBI3.
KOiK10744.
OMAiGARQHVF.
OrthoDBiEOG091G0M4Q.
TreeFamiTF105250.

Gene expression databases

BgeeiENSBTAG00000020149.

Family and domain databases

CDDicd09270. RNase_H2-B. 1 hit.
InterProiIPR019024. RNase_H2_suB.
[Graphical view]
PfamiPF09468. RNase_H2-Ydr279. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRNH2B_BOVIN
AccessioniPrimary (citable) accession number: Q3ZBI3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: September 5, 2006
Last modified: September 7, 2016
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.